Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos [PDF]
Nature Communications, 2020 The organisation of chromatin in somatic cell nuclear transfer (SCNT) embryos remains poorly understood. Here, the authors examine higher order chromatin structures of mouse SCNT embryos and provide insights into chromatin architecture reorganisation ...
Mo Chen +13 more
doaj +3 more sources
Lessons Learned from Somatic Cell Nuclear Transfer. [PDF]
Int J Mol Sci, 2020 Somatic cell nuclear transfer (SCNT) has been an area of interest in the field of stem cell research and regenerative medicine for the past 20 years.
Gouveia C, Huyser C, Egli D, Pepper MS.
europepmc +7 more sources
Epigenetic Reprogramming During Somatic Cell Nuclear Transfer: Recent Progress and Future Directions [PDF]
Frontiers in Genetics, 2020 Somatic cell nuclear transfer (SCNT) has broad applications but is limited by low cloning efficiency. In this review, we mainly focus on SCNT-mediated epigenetic reprogramming in livestock and also describe mice data for reference.
Xiangyu Wang +5 more
doaj +3 more sources
Strategies to Improve the Efficiency of Somatic Cell Nuclear Transfer. [PDF]
Int J Mol Sci, 2022 Mammalian oocytes can reprogram differentiated somatic cells into a totipotent state through somatic cell nuclear transfer (SCNT), which is known as cloning.
Srirattana K, Kaneda M, Parnpai R.
europepmc +2 more sources
Generating Cloned Goats by Somatic Cell Nuclear Transfer-Molecular Determinants and Application to Transgenics and Biomedicine. [PDF]
Int J Mol Sci, 2021 The domestic goat (Capra aegagrus hircus), a mammalian species with high genetic merit for production of milk and meat, can be a tremendously valuable tool for transgenic research.
Skrzyszowska M, Samiec M.
europepmc +2 more sources
Generation of genome-edited dogs by somatic cell nuclear transfer [PDF]
BMC Biotechnology, 2022 Background Canine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome-editing tools such as CRISPR-Cas9 can be used to correct pathogenic mutations in purebred dogs or to generate animal models of disease.
Dong-Ern Kim +6 more
doaj +2 more sources
Advance in the Role of Epigenetic Reprogramming in Somatic Cell Nuclear Transfer-Mediated Embryonic Development. [PDF]
Stem Cells Int, 2021 Somatic cell nuclear transfer (SCNT) enables terminally differentiated somatic cells to gain totipotency. Many species are successfully cloned up to date, including nonhuman primate. With this technology, not only the protection of endangered animals but
Zhang X, Gao S, Liu X.
europepmc +2 more sources
Somatic Cell Nuclear Transfer [PDF]
Encyclopedia of Gerontology and Population Aging, 2020 Some people may be laughing when looking at you reading in your spare time. Some may be admired of you. And some may want be like you who have reading hobby. What about your own feel? Have you felt right? Reading is a need and a hobby at once.
Parker Y. L. Tsang +2 more
semanticscholar +2 more sources
25th ANNIVERSARY OF CLONING BY SOMATIC-CELL NUCLEAR TRANSFER: Nuclear transfer and the development of genetically modified/gene edited livestock. [PDF]
Reproduction, 2021 The birth and adult development of 'Dolly' the sheep, the first mammal produced by the transfer of a terminally differentiated cell nucleus into an egg, provided unequivocal evidence of nuclear equivalence among somatic cells.
Alberio R, Wolf E.
europepmc +2 more sources
Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer [PDF]
Cell, 2018 Generation of genetically uniform non-human primates may help to establish animal models for primate biology and biomedical research. In this study, we have successfully cloned cynomolgus monkeys (Macaca fascicularis) by somatic cell nuclear transfer (SCNT).
Zhen Liu +10 more
semanticscholar +7 more sources