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Generation of genome-edited dogs by somatic cell nuclear transfer [PDF]
BMC Biotechnology, 2022 Background Canine cloning technology based on somatic cell nuclear transfer (SCNT) combined with genome-editing tools such as CRISPR-Cas9 can be used to correct pathogenic mutations in purebred dogs or to generate animal models of disease.
Dong-Ern Kim +6 more
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Mouse somatic cell nuclear transfer: What has changed and remained unchanged in 25 years [PDF]
The Journal of Reproduction and Development, 2023 Somatic cell nuclear transfer (SCNT) is the only reproductive technology used to produce individuals from somatic cells by transferring them to enucleated oocytes.
Kimiko INOUE
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Asymmetric nuclear reprogramming in somatic cell nuclear transfer? [PDF]
BioEssays, 2007 AbstractDespite the progress achieved over the last decade after the birth of the first cloned mammal, the efficiency of reproductive cloning remains invariably low. However, research aiming at the use of nuclear transfer for the production of patient‐tailored stem cells for cell/tissue therapy is progressing rapidly. Yet, reproductive cloning has many
Pasqualino Loi +4 more
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Somatic Cell Nuclear Transfer [PDF]
, 2007 Nuclear remodeling and nuclear reprogramming for making transgenic pigs by nuclear transfer.- Somatic cell nuclei in cloning: strangers traveling in a foreign land.- Cloning cattle: the methods in the madness.- Centrosome inheritance after fertilization and nuclear transfer in mammals.- Developmental, behavioral, and physiological phenotype of cloned ...
Peter Šutovský
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Applications of somatic cell nuclear transfer in goats
Journal of Advanced Veterinary and Animal Research, 2014 A number of animals with genetically identical appearance can be produced by somatic cell nuclear transfer (SCNT). From current advancement of SCNT and molecular techniques, production of a transgenic animal becomes easier. Although cloning efficiency in
Ton Yoisungnern, Ashit Kumar Paul
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Reproductive ability of minipigs as surrogates for somatic cell nuclear transfer [PDF]
Journal of Animal Science and TechnologyPigs are genetically, anatomically, and physiologically similar to humans. Recently, pigs are in the spotlight as a suitable source animal for xenotransplantation.
Joonho Moon +5 more
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Lessons Learned from Somatic Cell Nuclear Transfer. [PDF]
Int J Mol Sci, 2020 Somatic cell nuclear transfer (SCNT) has been an area of interest in the field of stem cell research and regenerative medicine for the past 20 years. The main biological goal of SCNT is to reverse the differentiated state of a somatic cell, for the purpose of creating blastocysts from which embryonic stem cells (ESCs) can be derived for therapeutic ...
Gouveia C, Huyser C, Egli D, Pepper MS.
europepmc +6 more sources
Lysophosphatidic acid improves development of porcine somatic cell nuclear transfer embryos [PDF]
Journal of Animal Science and TechnologyThis study was conducted to investigate whether lysophosphatidic acid (LPA) could improve the development of porcine somatic cell nuclear transfer (SCNT) embryos.
Ling Sun +5 more
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Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos [PDF]
Nature Communications, 2020 The organisation of chromatin in somatic cell nuclear transfer (SCNT) embryos remains poorly understood. Here, the authors examine higher order chromatin structures of mouse SCNT embryos and provide insights into chromatin architecture reorganisation ...
Mo Chen +13 more
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Cloned ferrets produced by somatic cell nuclear transfer
Developmental Biology, 2006 Somatic cell nuclear transfer (SCNT) offers great potential for developing better animal models of human disease. The domestic ferret (Mustela putorius furo) is an ideal animal model for influenza infections and potentially other human respiratory diseases such as cystic fibrosis, where mouse models have failed to reproduce the human disease phenotype.
Ziyi Li +8 more
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