Results 1 to 10 of about 546,473 (236)

Somatic cell nuclear transfer [PDF]

Nature, 2002
Cloning by nuclear transfer from adult somatic cells is a remarkable demonstration of developmental plasticity. When a nucleus is placed in oocyte cytoplasm, the changes in chromatin structure that govern differentiation can be reversed, and the nucleus can be made to control development to term.
Tim King, P.A. De Sousa, Nathalie Beaujean, Lorraine E. Young, Lorraine E. Young, D.N. Wells, L A Paterson, Andras Dinnyes, Andras Dinnyes, Ian Wilmut   +9 more
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Progress in the Reprogramming of Somatic Cells [PDF]

Circulation Research, 2013
Pluripotent stem cells can differentiate into nearly all types of cells in the body. This unique potential provides significant promise for cell-based therapies to restore tissues or organs destroyed by injuries, degenerative diseases, aging, or cancer.
Ma, Tianhua, Xie, Min, Laurent, Timothy, Ding, Sheng   +3 more
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Reprogramming somatic cells into stem cells [PDF]

Reproduction, 2006
Recent scientific achievements in cell and developmental biology have provided unprecedented opportunities for advances in biomedical research. The demonstration that fully differentiated cells can reverse their gene expression profile to that of a pluripotent cell, and the successful derivation and culture of human embryonic stem cells (ESCs) have ...
Ramiro Alberio, Keith H.S. Campbell, Andrew D. Johnson   +2 more
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Stem cells of Hydra magnipapillata can differentiate into somatic cells and germ line cells [PDF]

, 1987
We investigated whether all stem cells of Hydra can differentiate both somatic cells and gametes or if a separate germ line exists in these phylogenetically old organisms.
Bode, Bosch, Bosch, Bosch, Burnett, Buss, Buss, Buss, David, David, David, Diehl, Gierer, Heimfeld, Heimfeld, Lenhoff, Littlefield, Littlefield, Marcum, Marcum, Nieuwkoop, Park, Sachs, Sproull, Sugiyama, Sugiyama, Takano, Weismann, Weismann   +28 more
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The V_H gene repertoire of splenic B cells and somatic hypermutation in systemic lupus erythematosus [PDF]

, 2003
In systemic lupus erythematosus (SLE) it has been hypothesized that self-reactive B cells arise from virgin B cells that express low-affinity, nonpathogenic germline V genes that are cross-reactive for self and microbial antigens, which convert to high ...
Field, M., Fraser, N.L.W., Rowley, G., Stott, D.I.   +3 more
core   +2 more sources

The relationship between cell size and cell fate in Volvox carteri [PDF]

, 1993
In Volvox carteri development, visibly asymmetric cleavage divisions set apart large embryonic cells that will become asexual reproductive cells (gonidia) from smaller cells that will produce terminally differentiated somatic cells. Three mechanisms have
Kirk, David L., Kirk, Marilyn M., McRae, Stephen E., Ransick, Andrew   +3 more
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Somatic Stem Cells in the Endometrium

Reproductive Sciences, 2009
The human endometrium has cycles of growth, differentiation, and regeneration. In that respect, the concept that endometrial stem cells are responsible for the regenerative capacity of this tissue was proposed many years ago. Recently, the cells that present features of somatic stem cells have been identified in murine and human endometria where the ...
Carlos Simón, Irene Cervelló
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The cell of origin dictates the temporal course of neurofibromatosis-1 (Nf1) low-grade glioma formation. [PDF]

, 2017
Low-grade gliomas are one of the most common brain tumors in children, where they frequently form within the optic pathway (optic pathway gliomas; OPGs).
Castillon, Guillaume A, Cimino, Patrick J, Ellisman, Mark H, Gianino, Scott M, Gutmann, David H, Lee, Da Yong, Ma, Yu, Pan, Yuan, Solga, Anne C, Toonen, Joseph A   +9 more
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Germ Cells and Somatic Cells [PDF]

The American Naturalist, 1915
1. It is shown that evidence similar to that which makes probable the potential immortality of protozoa and germ cells also exists in the case of somatic cells of metazoa. As far as the protozoa are concerned, the discussion does not, as seems to be assumed, concern their potential immortality so much as the question whether protozoa correspond to germ
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Somatic cell origin of teratocarcinomas [PDF]

Proceedings of the National Academy of Sciences, 1978
Malignant teratocarcinomas arise from developmentally totipotent normal stem cells. Whether the targets are embryonal somatic cells or germinal cells has long been a matter of controversy. Past experiments on teratocarcinoma induction by ectopic grafting of early rodent embryos or fetal germinal ridges have remained ambiguous because ...
Mintz, B, Cronmiller, C, Custer, R P
openaire   +2 more sources