AID function in somatic hypermutation and class switch recombination [PDF]
Acta Biochimica et Biophysica Sinica, 2022 Activation-induced cytidine deaminase (AID) initiates somatic hypermutation of immunoglobulin (Ig) gene variable regions and class switch recombination (CSR) of Ig heavy chain constant regions.
Yu Kefei
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Tandem Substitutions in Somatic Hypermutation [PDF]
Frontiers in Immunology, 2022 Upon antigen recognition, activation-induced cytosine deaminase initiates affinity maturation of the B-cell receptor by somatic hypermutation (SHM) through error-prone DNA repair pathways. SHM typically creates single nucleotide substitutions, but tandem
Julieta H. Sepúlveda-Yáñez +10 more
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Topologically Associated Domains Delineate Susceptibility to Somatic Hypermutation
Cell Reports, 2019 Summary: Somatic hypermutation (SHM) introduces point mutations into immunoglobulin (Ig) genes but also causes mutations in other parts of the genome.
Filip Senigl +13 more
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Antibody Dynamics Simulation—A Mathematical Exploration of Clonal Deletion and Somatic Hypermutation [PDF]
Biomedicines, 2023 We have employed mathematical modeling techniques to construct a comprehensive framework for elucidating the intricate response mechanisms of the immune system, facilitating a deeper understanding of B-cell clonal deletion and somatic hypermutation.
Zhaobin Xu +4 more
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HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation. [PDF]
Genes Dev, 2022 Here, Wu et al. demonstrate that the DNA repair factor HMCES strongly suppresses deletions without significantly affecting other parameters of somatic hypermutation in mouse and human B cells, thereby facilitating the production of antigen-specific ...
Wu L +6 more
europepmc +2 more sources
Regulated somatic hypermutation enhances antibody affinity maturation. [PDF]
NatureGerminal centres are specialized microenvironments where B cells undergo affinity maturation. B cells expressing antibodies whose affinity is improved by somatic hypermutation are selected for expansion by limiting numbers of T follicular helper cells ...
Merkenschlager J +8 more
europepmc +2 more sources
Altered somatic hypermutation patterns in COVID-19 patients classifies disease severity [PDF]
Frontiers in Immunology, 2023 IntroductionThe success of the human body in fighting SARS-CoV2 infection relies on lymphocytes and their antigen receptors. Identifying and characterizing clinically relevant receptors is of utmost importance.MethodsWe report here the application of a ...
Modi Safra +21 more
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The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential tumorigenic activity [PDF]
Tumour Virus ResearchSimian virus 40 (SV40) is a monkey virus with tumorigenic potential in rodents and is associated with several types of human cancers, including lymphomas.
Filip Šenigl +6 more
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Involvement of Rad18 in somatic hypermutation [PDF]
Proceedings of the National Academy of Sciences, 2006 Somatic hypermutation of Ig genes is initiated by transcription-coupled cytidine deamination in Ig loci. Error-prone processing of the resultant DNA lesions is thought to cause extensive mutagenesis, but it is presently an enigma how and why error-prone rather than error-free repair pathways are recruited.
Jürgen Bachl +2 more
openalex +4 more sources