Results 101 to 110 of about 280,773 (255)

Distinct Roles of IL‐4, IL‐13, and IL‐22 in Human Skin Barrier Dysfunction and Atopic Dermatitis

Allergy, Volume 81, Issue 2, Page 480-497, February 2026.
This study reports the distinct effects of IL‐4, IL‐13, and IL‐22 on bio‐stabilized human skin with intact barriers and immune cells. IL‐4, IL‐13, and IL‐22 upregulate inflammatory mediators, disrupt skin barrier integrity, and reciprocally modulate IL‐4Rα and IL‐22Rα1 receptors.
Paolo D'Avino, Juno Kim, Manru Li, Philipp Gessner, Patrick Westermann, Yagız Pat, Carina Beha, Claudia Traidl‐Hoffmann, Jeremy Bost, Nicolas Gaudenzio, Christoph B. Messner, Cezmi A. Akdis, Yasutaka Mitamura   +12 more
wiley   +1 more source

DNA Replication to Aid Somatic Hypermutation [PDF]

, 2007
Immunoglobulin (Ig) heavy and light chain loci undergo V, (D) and J gene recombination in bone marrow, giving rise to the diverse pre-immune repertoire of V(D)J segments of B cell receptors (BCR). After encountering antigen, naive B cells divide and differentiate in germinal centers of secondary lymphoid organs.
Zhenming, Xu, Hong, Zan, Zsuzsanna, Pal, Paolo, Casali   +3 more
openaire   +2 more sources

B‐Cell Repertoire of Children With Atopic Dermatitis Exhibits Altered IgE Maturation Associated With Allergic Food Sensitization

Allergy, Volume 81, Issue 2, Page 513-523, February 2026.
IgH repertoire sequencing of a large atopic dermatitis cohort reveal reduced IgE somatic hypermutation and increased IgE diversity associated with food allergen sensitization. Presence of a dog during the first year of life is associated with increased IgE somatic hypermutation, possibly countering the effect of food sensitization.
Kirandeep K. Gill, Carolina Moore, Onyekachi Nwogu, John W. Kroner, Wan‐Chi Chang, Jeffrey Burkle, Samuel J. Virolainen, Mariana L. Stevens, Asel Baatyrbek, Emily R. Miraldi, Jocelyn M. Biagini, Ashley L. Devonshire, Leah Kottyan, Justin T. Schwartz, Amal H. Assa'ad, Lisa J. Martin, Sandra Andorf, Gurjit K. Khurana Hershey, Krishna M. Roskin   +18 more
wiley   +1 more source

Cryoglobulinemia: An update on classification, pathophysiology, clinical presentation, and management

Journal of Internal Medicine, Volume 299, Issue 2, Page 196-215, February 2026.
Abstract Cryoglobulinemia (CG) is defined by the presence of serum immunoglobulins that precipitate below 37°C and redissolve upon rewarming. It is classified into three types based on immunoglobulin composition. Type I, a rare form, involves monoclonal IgM or IgG and is linked to lymphoproliferative disorders.
Anna Linda Zignego, Laura Gragnani, Marcella Visentini, Riccardo Bomben, Luca Arcaini, Clodoveo Ferri, Valter Gattei, Cesare Mazzaro   +7 more
wiley   +1 more source

Tailored approaches grounded on immunogenetic features for refined prognostication in chronic lymphocytic leukemia

Haematologica, 2019
Chronic lymphocytic leukemia (CLL) patients with differential somatic hypermutation status of the immunoglobulin heavy variable genes, namely mutated or unmutated, display fundamental clinico-biological differences.
Panagiotis Baliakas, Theodoros Moysiadis, Anastasia Hadzidimitriou, Aliki Xochelli, Sabine Jeromin, Andreas Agathangelidis, Mattias Mattsson, Lesley-Ann Sutton, Eva Minga, Lydia Scarfò, Davide Rossi, Zadie Davis, Neus Villamor, Helen Parker, Jana Kotaskova, Evangelia Stalika, Karla Plevova, Larry Mansouri, Diego Cortese, Alba Navarro, Julio Delgado, Marta Larrayoz, Emma Young, Achilles Anagnostopoulos, Karin E. Smedby, Gunnar Juliusson, Oonagh Sheehy, Mark Catherwood, Jonathan C. Strefford, Niki Stavroyianni, Chrysoula Belessi, Sarka Pospisilova, David Oscier, Gianluca Gaidano, Elias Campo, Claudia Haferlach, Paolo Ghia, Richard Rosenquist, Kostas Stamatopoulos   +38 more
doaj   +1 more source

Nuclear DNA of plastid origin (NUPTs), neglected driver of genome variation and evolutionary innovation

The Plant Journal, Volume 125, Issue 3, February 2026.
Significance Statement Contrary to expectation, NUPTs do not necessarily have a deleterious or ultimately neutral impact, nor are they necessarily purged from the genome. Instead, they can proliferate and eventually become fixed, generating new and novel genes, gene regions and regulatory elements, thereby significantly contributing to plant nuclear ...
Lorenzo Carretero‐Paulet, Juan Pablo Marczuk‐Rojas, Aaron Gálvez‐Salido   +2 more
wiley   +1 more source

Enhancers Improve the AID-Induced Hypermutation in Episomal Vector for Antibody Affinity Maturation in Mammalian Cell Display

Antibodies, 2018
The induction of somatic hypermutation (SHM) in various cell lines by activation-induced cytidine deaminase (AID) has been used in protein-directed selection, especially in antibody affinity maturation.
Chuan Chen, Jie Wang, Yun Zhao, Shaopeng Chen, Zhishang Hu, Long Chen, Haiying Hang   +6 more
doaj   +1 more source

Sex differences in the clinical presentation of patients with newly diagnosed multiple myeloma

Cancer, Volume 132, Issue 2, 15 January 2026.
Abstract Introduction Standardized incidence rates of multiple myeloma (MM) are higher among males than females, suggesting that male sex is an important risk factor for MM, which may affect disease etiology, pathogenesis, and clinical presentation. Methods The association of sex with the prevalence of clinical features and chromosomal abnormalities ...
Krystle L. Ong, Kevin D. Arnold, Meredith C. Wessel, Gayatri Ravi, Faith E. Davies, Gareth J. Morgan, Elizabeth E. Brown   +6 more
wiley   +1 more source

Models of Somatic Hypermutation Targeting and Substitution Based on Synonymous Mutations from High-Throughput Immunoglobulin Sequencing Data

Frontiers in Immunology, 2013
Analyses of somatic hypermutation (SHM) patterns in B cell immunoglobulin (Ig) sequences contribute to our basic understanding of adaptive immunity, and have broad applications not only for understanding the immune response to pathogens, but also to ...
Gur Yaari, J. V. Vander Heiden, Mohamed Uduman, Daniel Gadala-Maria, N. Gupta, Joel N.H. Stern, K. O’Connor, D. Hafler, Uri Laserson, Francois Vigneault, S. Kleinstein   +10 more
semanticscholar   +1 more source

Enhancer‐dependent gene regulation in space, time, and malignancies

International Journal of Cancer, Volume 158, Issue 2, Page 357-367, 15 January 2026.
Abstract Control of cell‐type‐specific gene activation requires the coordinated activity of distal regulatory elements, including enhancers, whose inputs must be temporally integrated. Dysregulation of this regulatory capacity, such as aberrant usage of enhancers, can result in malignant transformation of cells.
Belinda Blum, Victoria Dachtler, Angelika Feldmann   +2 more
wiley   +1 more source