Results 11 to 20 of about 280,773 (255)

Reverse Transcriptase Mechanism of Somatic Hypermutation: 60 Years of Clonal Selection Theory

Frontiers in Immunology, 2017
The evidence for the reverse transcriptase mechanism of somatic hypermutation is substantial and multifactorial. In this 60th anniversary year of the publication of Sir MacFarlane Burnet’s Clonal Selection Theory, the evidence is briefly reviewed and ...
Edward J. Steele
doaj   +2 more sources

Mutating for Good: DNA Damage Responses During Somatic Hypermutation

Frontiers in Immunology, 2019
Somatic hypermutation (SHM) of immunoglobulin (Ig) genes plays a key role in antibody mediated immunity. SHM in B cells provides the molecular basis for affinity maturation of antibodies.
Bas Pilzecker, Heinz Jacobs
doaj   +2 more sources

V(D)J recombination, somatic hypermutation and class switch recombination of immunoglobulins: mechanism and regulation

Immunology, 2020
Immunoglobulins emerging from B lymphocytes and capable of recognizing almost all kinds of antigens owing to the extreme diversity of their antigen‐binding portions, known as variable (V) regions, play an important role in immune responses.
Xiying Chi, Yue Li, Xiaoyan Qiu
semanticscholar   +3 more sources

A somatic hypermutation-based machine learning model stratifies individuals with Crohn's disease and controls. [PDF]

Genome Res, 2023
Safra M, Werner L, Peres A, Polak P, Salamon N, Schvimer M, Weiss B, Barshack I, Shouval DS, Yaari G.   +9 more
europepmc   +3 more sources

B cell somatic hypermutation following COVID-19 vaccination with Ad26.COV2.S [PDF]

iScience
Summary: The viral vector-based COVID-19 vaccine Ad26.COV2.S has been recommended by the WHO since 2021 and has been administered to over 200 million people.
Catherine Jacob-Dolan, Michelle Lifton, Olivia C. Powers, Jessica Miller, Nicole P. Hachmann, Mya Vu, Nehalee Surve, Camille R. Mazurek, Jana L. Fisher, Stefanie Rodrigues, Robert C. Patio, Trisha Anand, Mathieu Le Gars, Jerald Sadoff, Aaron G. Schmidt, Dan H. Barouch   +15 more
doaj   +2 more sources

Thrifty wide-context models of B cell receptor somatic hypermutation [PDF]

eLife
Somatic hypermutation (SHM) is the diversity-generating process in antibody affinity maturation. Probabilistic models of SHM are needed for analyzing rare mutations, understanding the selective forces guiding affinity maturation, and understanding the ...
Kevin Sung, Mackenzie M Johnson, Will Dumm, Noah Simon, Hugh Haddox, Julia Fukuyama, Frederick A Matsen   +6 more
doaj   +2 more sources

SETD2 Haploinsufficiency Enhances Germinal Center-Associated AICDA Somatic Hypermutation to Drive B-cell Lymphomagenesis. [PDF]

Cancer Discov, 2022
Leung W, Teater M, Durmaz C, Meydan C, Chivu AG, Chadburn A, Rice EJ, Muley A, Camarillo JM, Arivalagan J, Li Z, Flowers CR, Kelleher NL, Danko CG, Imielinski M, Dave SS, Armstrong SA, Mason CE, Melnick AM.   +18 more
europepmc   +3 more sources

Somatic Hypermutation: Another piece in the hypermutation puzzle [PDF]

Current Biology, 1995
AbstractStudies with transgenic mice are beginning to define the minimal requirements for the somatic hypermutation of immunoglobulin genes that is critical in the production of high-affinity antibodies.
David B. Winter, Patricia J. Gearhart
openalex   +3 more sources

Structural Basis of Antibody Conformation and Stability Modulation by Framework Somatic Hypermutation. [PDF]

Front Immunol, 2021
Sheng Z, Bimela JS, Katsamba PS, Patel SD, Guo Y, Zhao H, Guo Y, Kwong PD, Shapiro L.   +8 more
europepmc   +2 more sources

Targeting of somatic hypermutation by immunoglobulin enhancer and enhancer-like sequences.

PLoS Biology, 2014
Somatic hypermutation (SH) generates point mutations within rearranged immunoglobulin (Ig) genes of activated B cells, providing genetic diversity for the affinity maturation of antibodies.
Jean-Marie Buerstedde, Jukka Alinikula, Hiroshi Arakawa, Jessica J McDonald, David G Schatz   +4 more
doaj   +2 more sources