Results 21 to 30 of about 280,773 (255)

A Small Step, a Giant Leap: Somatic Hypermutation of a Single Amino Acid Leads to Anti-La Autoreactivity. [PDF]

Int J Mol Sci, 2021
Bartsch T, Arndt C, Loureiro LR, Kegler A, Puentes-Cala E, Soto JA, Kurien BT, Feldmann A, Berndt N, Bachmann MP.   +9 more
europepmc   +3 more sources

Expression of Constitutive Fusion of Ubiquitin to PCNA Restores the Level of Immunoglobulin A/T Mutations During Somatic Hypermutation in the Ramos Cell Line. [PDF]

Front Immunol, 2022
Lerner LK, Bonte D, Le Guillou M, Mohammad MM, Kasraian Z, Sarasin A, Despras E, Aoufouchi S.   +7 more
europepmc   +3 more sources

What Targets Somatic Hypermutation to the Immunoglobulin Loci? [PDF]

Viral Immunol, 2020
Heltzel JMH, Gearhart PJ.
europepmc   +3 more sources

Complementary Roles of Antibody Heavy and Light Chain Somatic Hypermutation in Conferring Breadth and Potency to the HIV-1-Specific CAP256-VRC26 bNAb Lineage. [PDF]

J Virol, 2022
Sacks D, Wiehe K, Morris L, Moore PL.
europepmc   +3 more sources

Germline APOBEC3B deletion increases somatic hypermutation in Asian breast cancer that is associated with Her2 subtype, PIK3CA mutations and immune activation

International Journal of Cancer, 2021
A 30‐kb deletion that eliminates the coding region of APOBEC3B (A3B) is >5 times more common in women of Asian descent compared to European descent.
Jia-Wern Pan, M. Zabidi, Boon-Keat Chong, M. Meng, P. Ng, S. N. Hasan, B. Sandey, Saira Bahnu, P. Rajadurai, C. Yip, O. Rueda, C. Caldas, S. Chin, S. Teo   +13 more
semanticscholar   +1 more source

Histone H2A and H2B are monoubiquitinated at AID-targeted loci. [PDF]

PLoS ONE, 2010
Somatic hypermutation introduces base substitutions into the rearranged and expressed immunoglobulin (Ig) variable regions to promote immunity. This pathway requires and is initiated by the Activation Induced Deaminase (AID) protein, which deaminates ...
Glen M Borchert, Nathaniel W Holton, Kevin A Edwards, Laura A Vogel, Erik D Larson   +4 more
doaj   +1 more source

Tandem Substitutions in Somatic Hypermutation

Blood, 2021
Upon antigen recognition, activation-induced cytosine deaminase initiates affinity maturation of the B-cell receptor by somatic hypermutation (SHM) through error-prone DNA repair pathways.
Marvyn T. Koning, J. H. Sepúlveda Yáñez, Diego Alvarez-Saravia, B. Pilzecker, Pauline Van Schouwenburg, Mirjam van den Burg, Marcelo A. Navarrete, Heinz Jacobs, Hendrik Veelken   +8 more
semanticscholar   +1 more source

Rapid Hypermutation B Cell Trajectory Recruits Previously Primed B Cells Upon Third SARS-Cov-2 mRNA Vaccination

Frontiers in Immunology, 2022
The COVID-19 pandemic shows that vaccination strategies building on an ancestral viral strain need to be optimized for the control of potentially emerging viral variants.
Lisa Paschold, Bianca Klee, Cornelia Gottschick, Edith Willscher, Sophie Diexer, Christoph Schultheiß, Donjete Simnica, Daniel Sedding, Matthias Girndt, Michael Gekle, Rafael Mikolajczyk, Mascha Binder   +11 more
doaj   +1 more source

Somatic immunoglobulin hypermutation [PDF]

Current Opinion in Immunology, 2002
Immunoglobulin hypermutation provides the structural correlate for the affinity maturation of the antibody response. Characteristic modalities of this mechanism include a preponderance of point-mutations with prevalence of transitions over transversions, and the mutational hotspot RGYW sequence.
Marilyn, Diaz, Paolo, Casali
openaire   +2 more sources

Modulation of Pleurodeles waltl DNA polymerase mu expression by extreme conditions encountered during spaceflight. [PDF]

PLoS ONE, 2013
DNA polymerase µ is involved in DNA repair, V(D)J recombination and likely somatic hypermutation of immunoglobulin genes. Our previous studies demonstrated that spaceflight conditions affect immunoglobulin gene expression and somatic hypermutation ...
Véronique Schenten, Nathan Guéguinou, Sarah Baatout, Jean-Pol Frippiat   +3 more
doaj   +1 more source