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Purification of bovine somatomedin
Biochemical and Biophysical Research Communications, 1975Abstract A procedure for the purification of bovine somatomedin (SM 4 ) is presented. The purification scheme utilizes ultrafiltration through membranes of nominal mol. wt. cutoffs, molecular sieve chromatography and finally iso-electric focusing.
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Somatomedin Inhibitor in Uremia*
The Journal of Clinical Endocrinology & Metabolism, 1984In uremia, poor growth occurs despite normal to increased levels of insulin and GH. Since serum somatomedin levels measured by RIA and radioreceptor assay are normal in patients with renal failure, while serum somatomedin activity measured by bioassay is low but increased by dialysis, we asked if somatomedin activity could be decreased due to the ...
Lawrence S. Phillips +3 more
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Radioimmunoassay of Somatomedin B
1975Publisher Summary This chapter provides an overview of radioimmunoassay of somatomedin B. The sensitivity of the assay permits the measurement of this factor in human plasma diluted 1:20,000 and in monkey plasma diluted 1:5000. Somatomedin B is not detected in many nonprimate plasmas diluted 1:20.
Rolf Luft +3 more
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Metabolism, 1989
Circulating somatomedin activity reflects the presence of both somatomedins and somatomedin inhibitors, factors which antagonize the growth-promoting actions of somatomedins. Although both are regulated by nutrition, somatomedin inhibitors respond more rapidly than somatomedins to refeeding in fasted animals.
Lawrence S. Phillips, Steven Goldstein
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Circulating somatomedin activity reflects the presence of both somatomedins and somatomedin inhibitors, factors which antagonize the growth-promoting actions of somatomedins. Although both are regulated by nutrition, somatomedin inhibitors respond more rapidly than somatomedins to refeeding in fasted animals.
Lawrence S. Phillips, Steven Goldstein
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Nutrition and Somatomedin: III. Diabetic Control, Somatomedin, and Growth in Rats
Diabetes, 1977Observations of a growth hormone-resistant decrease in somatomedin activity associated with conditions of insulinopenia suggest that somatomedin and growth might be related to metabolic control in diabetes mellitus. We examined this relationship by comparing measures of insulin effect with serum somatomedin activity (porcine cartilage bioassay ...
Lawrence S. Phillips, Arthur T. Orawski
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Nutrition and Somatomedin. VII. Regulation of Somatomedin Activity by the Perfused Rat Liver*
Endocrinology, 1980Skeletal growth is currently attributed to stimulation of cartilage proliferation by somatomedins. To assess the potential regulation of circulating somatomedin activity by the liver, rats were subjected to different metabolic conditions, their livers were perfused in situ for 2 h, and samples were obtained every 30 min.
Larry A. Reichard +2 more
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Nutrition, somatomedins, and the brain
Metabolism, 1986Conditions of decreased nutrient supply (malnutrition) and/or decreased nutrient utilization (diabetes) are attended by impairment of growth despite an increase in circulating levels of growth hormone (GH). Growth involves the actions of somatomedins, circulating insulinlike polypeptides with anabolic effects on cartilage, fat, and muscle.
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THE LIVER AS A SOURCE OF SOMATOMEDIN
Acta Endocrinologica, 1976ABSTRACT Somatomedin (Sm) activity (measured by [35S] uptake in chick embryo cartilage) was determined in serum samples simultaneously drawn from the hepatic vein, portal vein, femoral artery and femoral vein of seventeen anaesthezied normal adult dogs). A pool of human serum was taken as reference (Sm = 1 U/ml).
J. C. Glasinovic +4 more
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Somatomedin activity in the Mauriac syndrome
The Journal of Pediatrics, 19807. Sirinavin S, and McCracken GH: Primary suppurative myositis in children, Am J Dis Child 133:263, 1979. 8. Blair DC, Carroll M, and Silva J: Localization of infectious process with gallium citrate Ga 67, JAMA 230:82, 1974. 9. Hopkins GB, Kan M, and Mende CW: Early 67 Ga scintigraphy for the localization of abdominal abscesses, J Nucl Med 16:990, 1975.
Orville C. Green +3 more
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The biosynthesis of somatomedins and their role in the fetus
Acta Endocrinologica, 1986Abstract The somatomedins are a family of hormones consisting of insulin-like growth factors 1 and 2 as well as their variant forms. These peptides have a direct growth-promoting action on fetal cells mediated through their interaction with Type I and II receptors distributed throughout the fetus.
Christine Carlsson-Skwirut +1 more
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