Results 201 to 210 of about 13,712 (280)
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Medical Journal of Australia, 1975
An intact pituitary gland capable of secreting growth hormone has long been considered the prime requirement for the achievement of skeletal growth potential in man. Recent studies have revealed that the growth-promoting action of growth hormone is an in-vivo phenomenon which cannot be mimicked by the addition of the hormone to skeletal tissue in vitro.
K, Hall +3 more
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An intact pituitary gland capable of secreting growth hormone has long been considered the prime requirement for the achievement of skeletal growth potential in man. Recent studies have revealed that the growth-promoting action of growth hormone is an in-vivo phenomenon which cannot be mimicked by the addition of the hormone to skeletal tissue in vitro.
K, Hall +3 more
openaire +4 more sources
Clinical Orthopaedics and Related Research, 1975
Somatomedin is a peptide component of serum which has been postulated to mediate the action of growth hormone on skeletal tissue. Direct effects on cartilage include stimulation of the synthesis of mucopolysacharide, protein, and nucleic acids. Insulin-like effects on non-skeletal tissues and cells have been described, and a relationship to NSILA-S and
J D, Bomboy, W D, Salmon
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Somatomedin is a peptide component of serum which has been postulated to mediate the action of growth hormone on skeletal tissue. Direct effects on cartilage include stimulation of the synthesis of mucopolysacharide, protein, and nucleic acids. Insulin-like effects on non-skeletal tissues and cells have been described, and a relationship to NSILA-S and
J D, Bomboy, W D, Salmon
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Glucocorticoid Effects on Somatomedins and Somatomedin Inhibitors*
The Journal of Clinical Endocrinology & Metabolism, 1985Glucocorticoid excess may be associated with poor growth despite normal levels of GH and adequate nutrition. Steroid-induced growth failure could be mediated by defective generation and/or action of somatomedins. To probe potential mechanisms, we examined the effect of corticosteroid administration on net somatomedin activity, immunoreactive ...
Lawrence S. Phillips, Unterman Tg
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Science, 1981
Somatomedin-C stimulates somatostatin release to a maximum of 390 percent of basal release during short-term (20-minute) incubation of rat hypothalamus.
M. Berelowitz +5 more
semanticscholar +1 more source
Somatomedin-C stimulates somatostatin release to a maximum of 390 percent of basal release during short-term (20-minute) incubation of rat hypothalamus.
M. Berelowitz +5 more
semanticscholar +1 more source
Cellular localization of somatomedin (insulin-like growth factor) messenger RNA in the human fetus.
Science, 1987The somatomedins or insulin-like growth factors (IGFs) are synthesized in many organs and tissues, but the specific cells that synthesize them in vivo have not been defined.
V. K. Han, A. D'ercole, P. Lund
semanticscholar +1 more source
Hormone Research, 1986
Somatomedin levels measured by radioreceptor assay, competitive protein-binding assay or radioimmunoassay are normal in hypercortisolism; the decrease of somatomedin activity consistently found in this condition is due to an increase in circulating somatomedin inhibitors resulting in an inhibition of somatomedin action. Progestagens could possibly have
Caufriez, Anne, Copinschi, Georges
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Somatomedin levels measured by radioreceptor assay, competitive protein-binding assay or radioimmunoassay are normal in hypercortisolism; the decrease of somatomedin activity consistently found in this condition is due to an increase in circulating somatomedin inhibitors resulting in an inhibition of somatomedin action. Progestagens could possibly have
Caufriez, Anne, Copinschi, Georges
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Insulin-like growth factors and their binding proteins: biological actions.
Endocrine reviews, 1995I. Introduction THE insulin-like growth factors were discovered on the basis of their ability to stimulate cartilage sulfation and to replace the “sulfation factor activity” of GH, as determined using an in vivo assay, in an in vitro test system (1). The
John I. Jones, D. Clemmons
semanticscholar +1 more source
Nutrition and somatomedin XVI: Somatomedins and somatomedin inhibitors in fasted and refed rats
Metabolism, 1988Nutritional deprivation is associated with poor growth and decreased levels of net circulating somatomedin activity, as measured by bioassay. Since somatomedin activity reflects the contributions both of somatomedins (which stimulate cartilage) and of somatomedin inhibitors (which antagonize the ability of the somatomedins to stimulate cartilage), we ...
J.R. Gavin +5 more
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International Journal of Biochemistry, 1985
Bioassayable somatomedins and somatomedin inhibitors were examined after chromatographic separation, using serum from normal rats (enriched in somatomedins) and diabetic rats (enriched in somatomedin inhibitors). At neutral pH, gel filtration on Sephacryl S-300 revealed somatomedins at mol.
Alan C. Fusco +5 more
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Bioassayable somatomedins and somatomedin inhibitors were examined after chromatographic separation, using serum from normal rats (enriched in somatomedins) and diabetic rats (enriched in somatomedin inhibitors). At neutral pH, gel filtration on Sephacryl S-300 revealed somatomedins at mol.
Alan C. Fusco +5 more
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Reduction of plasma immunoreactive somatomedin C during fasting in humans.
Journal of Clinical Endocrinology and Metabolism, 1981We have assessed the effect of fasting for 10 days on plasma concentrations of immunoreactive somatomedin C and urinary urea excretion in seven obese male volunteers. From a mean prefast value of 0.83 U/ml, plasma somatomedin C fell to 0.21 U/ml after 10
David R. Clemmons +6 more
semanticscholar +1 more source