Results 211 to 220 of about 13,712 (280)
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Evaluation of acromegaly by radioimmunoassay of somatomedin-C.
New England Journal of Medicine, 1979We measured serum concentrations of somatomedin-C by radioimmunoassay in 57 acromegalic patients and compared them with various indicators of disease activity. The mean fasting somatomedin-C concentration was 6.8 U per milliliter (range, 2.6 to 21.7) for
David R. Clemmons +5 more
semanticscholar +1 more source
Normal Somatomedin and Somatomedin Receptors in Achondroplastic Dwarfism
Hormone and Metabolic Research, 1980It has been proposed that the basic abnormality in achondroplasia may be a quantitative defect in endochondral new bone formation secondary to decreased synthesis of somatomedin (SM) or abnormal binding of SM to specific receptors. To test this hypothesis, we have measured plasma SM levels and SM receptors on circulating mononuclear cells obtained from
Ron G. Rosenfeld, Raymond L. Hintz
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Journal of Clinical Endocrinology and Metabolism, 1980
The induction of somatomedin C (SM-C) was evaluated in 30 hypopituitary patients and in normal subjects using a sensitive, specific RIA for SM-C. Two hypopituitary patients each received an iv bolus of 0.1 U human GH (hGH)⁄kg BW, followed by continuous ...
Kenneth C. Copeland +2 more
semanticscholar +1 more source
The induction of somatomedin C (SM-C) was evaluated in 30 hypopituitary patients and in normal subjects using a sensitive, specific RIA for SM-C. Two hypopituitary patients each received an iv bolus of 0.1 U human GH (hGH)⁄kg BW, followed by continuous ...
Kenneth C. Copeland +2 more
semanticscholar +1 more source
Endocrinology, 1983
To investigate the feedback control of GH secretion, we examined the effects of human GH (hGH) and somatomedin C (SmC) on spontaneous GH secretory surges in unanesthetized, freely moving rats. Under pentobarbital anesthesia a right atrial catheter and an
Hiromi Abe +4 more
semanticscholar +1 more source
To investigate the feedback control of GH secretion, we examined the effects of human GH (hGH) and somatomedin C (SmC) on spontaneous GH secretory surges in unanesthetized, freely moving rats. Under pentobarbital anesthesia a right atrial catheter and an
Hiromi Abe +4 more
semanticscholar +1 more source
Acta Endocrinologica, 1984
A radioimmunoassay was developed for somatomedin-binding protein isolated from human amniotic fluid. The mean level in amniotic samples from 20-22 week of gestation was high, 51 micrograms/ml.
G. Póvoa, A. Roovete, K. Hall
semanticscholar +1 more source
A radioimmunoassay was developed for somatomedin-binding protein isolated from human amniotic fluid. The mean level in amniotic samples from 20-22 week of gestation was high, 51 micrograms/ml.
G. Póvoa, A. Roovete, K. Hall
semanticscholar +1 more source
1983
Publisher Summary This chapter presents a personal approach to the somatomedins, from their beginnings as operationally defined activities to their emergence, in the last decade, as structural entities. The existence of other growth factors isolated from serum and tissue such as epidermal growth factor and platelet-derived growth factor are also ...
V R Sara, K Hall
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Publisher Summary This chapter presents a personal approach to the somatomedins, from their beginnings as operationally defined activities to their emergence, in the last decade, as structural entities. The existence of other growth factors isolated from serum and tissue such as epidermal growth factor and platelet-derived growth factor are also ...
V R Sara, K Hall
openaire +3 more sources
Endocrinology, 1986
The hypothesis that GH may affect gonadal function by increasing local levels of the GH-dependent somatomedin C/insulin-like growth factor I (IGF I) was tested.
J. Davoren, AARON J.W. Hsdeh
semanticscholar +1 more source
The hypothesis that GH may affect gonadal function by increasing local levels of the GH-dependent somatomedin C/insulin-like growth factor I (IGF I) was tested.
J. Davoren, AARON J.W. Hsdeh
semanticscholar +1 more source
Journal of Clinical Endocrinology and Metabolism, 1988
We measured plasma insulin-like growth factor I/somatomedin-C (IGF-I/SmC) concentrations and mean 24-h GH secretion serially before and during therapy with the long-acting somatostatin analog SMS 201-995 in 21 patients with acromegaly.
A. Barkan, I. Beitins, R. Kelch
semanticscholar +1 more source
We measured plasma insulin-like growth factor I/somatomedin-C (IGF-I/SmC) concentrations and mean 24-h GH secretion serially before and during therapy with the long-acting somatostatin analog SMS 201-995 in 21 patients with acromegaly.
A. Barkan, I. Beitins, R. Kelch
semanticscholar +1 more source
Journal of Clinical Endocrinology and Metabolism, 1986
To determine the effects of estrogen deficiency and replacement on GH secretion, we measured the 22-h GH secretory pattern and response to 1 h of light exercise in 16 normal postmenopausal women before and after treatment replacement with ethinyl ...
B. Dawson-Hughes +3 more
semanticscholar +1 more source
To determine the effects of estrogen deficiency and replacement on GH secretion, we measured the 22-h GH secretory pattern and response to 1 h of light exercise in 16 normal postmenopausal women before and after treatment replacement with ethinyl ...
B. Dawson-Hughes +3 more
semanticscholar +1 more source
Endocrinology, 1979
Although serum from normal rats has somatomedin (cartilage-stimulating) activity, serum from diabetic rats often lacks somatomedin activity and can inhibit somatomedin activity when added to serum from normal rats; this is attributed to somatomedin inhibitor (s).
Larry A. Reichard +3 more
openaire +3 more sources
Although serum from normal rats has somatomedin (cartilage-stimulating) activity, serum from diabetic rats often lacks somatomedin activity and can inhibit somatomedin activity when added to serum from normal rats; this is attributed to somatomedin inhibitor (s).
Larry A. Reichard +3 more
openaire +3 more sources