Results 211 to 220 of about 14,130 (288)
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Hormone Research, 1986
Somatomedin levels measured by radioreceptor assay, competitive protein-binding assay or radioimmunoassay are normal in hypercortisolism; the decrease of somatomedin activity consistently found in this condition is due to an increase in circulating somatomedin inhibitors resulting in an inhibition of somatomedin action. Progestagens could possibly have
Caufriez, Anne, Copinschi, Georges
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Somatomedin levels measured by radioreceptor assay, competitive protein-binding assay or radioimmunoassay are normal in hypercortisolism; the decrease of somatomedin activity consistently found in this condition is due to an increase in circulating somatomedin inhibitors resulting in an inhibition of somatomedin action. Progestagens could possibly have
Caufriez, Anne, Copinschi, Georges
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Normal Somatomedin and Somatomedin Receptors in Achondroplastic Dwarfism
Hormone and Metabolic Research, 1980It has been proposed that the basic abnormality in achondroplasia may be a quantitative defect in endochondral new bone formation secondary to decreased synthesis of somatomedin (SM) or abnormal binding of SM to specific receptors. To test this hypothesis, we have measured plasma SM levels and SM receptors on circulating mononuclear cells obtained from
R G, Rosenfeld, R L, Hintz
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Nutrition and somatomedin XVI: Somatomedins and somatomedin inhibitors in fasted and refed rats
Metabolism, 1988Nutritional deprivation is associated with poor growth and decreased levels of net circulating somatomedin activity, as measured by bioassay. Since somatomedin activity reflects the contributions both of somatomedins (which stimulate cartilage) and of somatomedin inhibitors (which antagonize the ability of the somatomedins to stimulate cartilage), we ...
L S, Phillips, S, Goldstein, J R, Gavin
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1983
Publisher Summary This chapter presents a personal approach to the somatomedins, from their beginnings as operationally defined activities to their emergence, in the last decade, as structural entities. The existence of other growth factors isolated from serum and tissue such as epidermal growth factor and platelet-derived growth factor are also ...
K, Hall, V R, Sara
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Publisher Summary This chapter presents a personal approach to the somatomedins, from their beginnings as operationally defined activities to their emergence, in the last decade, as structural entities. The existence of other growth factors isolated from serum and tissue such as epidermal growth factor and platelet-derived growth factor are also ...
K, Hall, V R, Sara
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International Journal of Biochemistry, 1985
Bioassayable somatomedins and somatomedin inhibitors were examined after chromatographic separation, using serum from normal rats (enriched in somatomedins) and diabetic rats (enriched in somatomedin inhibitors). At neutral pH, gel filtration on Sephacryl S-300 revealed somatomedins at mol.
L S, Phillips +4 more
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Bioassayable somatomedins and somatomedin inhibitors were examined after chromatographic separation, using serum from normal rats (enriched in somatomedins) and diabetic rats (enriched in somatomedin inhibitors). At neutral pH, gel filtration on Sephacryl S-300 revealed somatomedins at mol.
L S, Phillips +4 more
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Wiener klinische Wochenschrift, 1987
Somatomedins are peptide hormones with insulin-like structure and effects. Their synthesis is governed by growth hormone. Somatomedins stimulate growth of cartilage tissue and other tissues. Synthesis of somatomedins occurs in various tissues, predominantly in the liver.
M B, Ranke, W, Blum, J R, Bierich
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Somatomedins are peptide hormones with insulin-like structure and effects. Their synthesis is governed by growth hormone. Somatomedins stimulate growth of cartilage tissue and other tissues. Synthesis of somatomedins occurs in various tissues, predominantly in the liver.
M B, Ranke, W, Blum, J R, Bierich
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Molecular and Cellular Endocrinology, 1984
The somatomedins, such as the insulin-like growth factors I and II, somatomedins A and C, and multiplication-stimulating activity, are small, growth hormone dependent polypeptides which are the assumed mediators of growth hormone action on extraskeletal tissues.
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The somatomedins, such as the insulin-like growth factors I and II, somatomedins A and C, and multiplication-stimulating activity, are small, growth hormone dependent polypeptides which are the assumed mediators of growth hormone action on extraskeletal tissues.
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Purification of bovine somatomedin
Biochemical and Biophysical Research Communications, 1975Abstract A procedure for the purification of bovine somatomedin (SM 4 ) is presented. The purification scheme utilizes ultrafiltration through membranes of nominal mol. wt. cutoffs, molecular sieve chromatography and finally iso-electric focusing.
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Growth Hormone and Somatomedin
1974Publisher Summary This chapter provides an overview of the growth hormone and somatomedin. It is well established that growth hormone in vivo promotes skeletal growth and protein synthesis. Growth hormone promotes protein synthesis by stimulating the appearance in the tissues of a secondary factor, sulfation factor or somatomedin, which transfers ...
K, Hall, R, Luft
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Annales de biologie clinique, 1991
Somatomedins or insulin-like growth factors (IGFs) are two polypeptides (IGF I and IGF II) whose structure shows great homology with proinsulin. Mostly synthetized by the liver but also by many tissues, they circulate in blood bound to specific binding proteins (IGFBPs).
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Somatomedins or insulin-like growth factors (IGFs) are two polypeptides (IGF I and IGF II) whose structure shows great homology with proinsulin. Mostly synthetized by the liver but also by many tissues, they circulate in blood bound to specific binding proteins (IGFBPs).
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