Results 231 to 240 of about 13,712 (280)

Effect of growth hormone on osteoblasts and demonstration of somatomedin-C/IGF I in bone organ culture.

Acta Endocrinologica, 1984
Bone organ culture makes it possible to observe the direct influence of hormones on bone cells. We studied the effect of growth hormone in vitro on embryonal rat tibiae during culture for 7 days, functionally by measuring the levels of alkaline ...
H. Stracke, A. Schulz, D. Moeller, S. Rossol, H. Schatz   +4 more
semanticscholar   +1 more source

Radioimmunoassay of Somatomedin B

1975
Publisher Summary This chapter provides an overview of radioimmunoassay of somatomedin B. The sensitivity of the assay permits the measurement of this factor in human plasma diluted 1:20,000 and in monkey plasma diluted 1:5000. Somatomedin B is not detected in many nonprimate plasmas diluted 1:20.
Rolf Luft, Rosalyn S. Yalow, Rosalyn S. Yalow, Kerstin Hall   +3 more
openaire   +3 more sources

Nutrition and somatomedin: Nutritionally regulated release of somatomedins and somatomedin inhibitors from perfused livers in rats

Metabolism, 1989
Circulating somatomedin activity reflects the presence of both somatomedins and somatomedin inhibitors, factors which antagonize the growth-promoting actions of somatomedins. Although both are regulated by nutrition, somatomedin inhibitors respond more rapidly than somatomedins to refeeding in fasted animals.
Lawrence S. Phillips, Steven Goldstein
openaire   +3 more sources

Nutrition and Somatomedin: III. Diabetic Control, Somatomedin, and Growth in Rats

Diabetes, 1977
Observations of a growth hormone-resistant decrease in somatomedin activity associated with conditions of insulinopenia suggest that somatomedin and growth might be related to metabolic control in diabetes mellitus. We examined this relationship by comparing measures of insulin effect with serum somatomedin activity (porcine cartilage bioassay ...
Lawrence S. Phillips, Arthur T. Orawski
openaire   +3 more sources

Somatomedin-C-mediated potentiation of follicle-stimulating hormone-induced aromatase activity of cultured rat granulosa cells.

Endocrinology, 1985
We have recently observed that nanomolar concentrations of exogenously added somatomedin-C (Sm-C) are capable of synergizing with FSH in the induction of cultured rat granulosa cell progesterone biosynthesis and LH receptors without altering granulosa ...
E. Y. Adashi, C. Resnick, Angela Brodie, M. Svoboda, J. J. Wyk   +4 more
semanticscholar   +1 more source

Nutrition, somatomedins, and the brain

Metabolism, 1986
Conditions of decreased nutrient supply (malnutrition) and/or decreased nutrient utilization (diabetes) are attended by impairment of growth despite an increase in circulating levels of growth hormone (GH). Growth involves the actions of somatomedins, circulating insulinlike polypeptides with anabolic effects on cartilage, fat, and muscle.
openaire   +3 more sources

Nutrition and Somatomedin. VII. Regulation of Somatomedin Activity by the Perfused Rat Liver*

Endocrinology, 1980
Skeletal growth is currently attributed to stimulation of cartilage proliferation by somatomedins. To assess the potential regulation of circulating somatomedin activity by the liver, rats were subjected to different metabolic conditions, their livers were perfused in situ for 2 h, and samples were obtained every 30 min.
Larry A. Reichard, Lawrence S. Phillips, Rena Vassilopoulou-Sellin   +2 more
openaire   +3 more sources

Partial characterization of a somatomedin-like peptide from the medium of cultured rat Sertoli cells.

Endocrinology, 1987
A peptide that is recognized by antibodies to human somatomedin-C/insulin-like growth factor I (Sm-C/IGF-I) has been partially purified from cultured Sertoli cells prepared from sexually immature rats.
Eric P. Smith, M. Svoboda, J. J. Wyk, A. Kierszenbaum, L. Tres   +4 more
semanticscholar   +1 more source

THE LIVER AS A SOURCE OF SOMATOMEDIN

Acta Endocrinologica, 1976
ABSTRACT Somatomedin (Sm) activity (measured by [35S] uptake in chick embryo cartilage) was determined in serum samples simultaneously drawn from the hepatic vein, portal vein, femoral artery and femoral vein of seventeen anaesthezied normal adult dogs). A pool of human serum was taken as reference (Sm = 1 U/ml).
J. C. Glasinovic, François Girard, R M Schimpff, J. M. Warnet, Marcel Donnadieu   +4 more
openaire   +3 more sources

Somatomedin-C in normal puberty and in true precocious puberty before and after treatment with a potent luteinizing hormone-releasing hormone agonist.

Journal of Clinical Endocrinology and Metabolism, 1985
To explore further the relationship of gonadal sex steroids to the rise in somatomedin-C (Sm-C) during puberty, we studied a group of children with true precocious puberty before and after treatment which suppressed sex steroid output.
David A. Harris, G. V. Vliet, C. A. Egli, M. M. Grumbach, Selna L. Kaplan, D. Styne, Marc Vainsel   +6 more
semanticscholar   +1 more source