Results 151 to 160 of about 84,280 (274)

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

Fragment Coverage: Unified Visualization and Quantitative Assessment of MS/MS Fragmentation Supports Metabolite Identification in Macromolecule Drug Metabolism Studies

Rapid Communications in Mass Spectrometry, Volume 40, Issue 21, 15 November 2026.
ABSTRACT Rationale Peptides and oligonucleotides are increasingly used as therapeutic agents, making the identification and structural elucidation of their metabolites a critical step in drug development. Liquid chromatography–mass spectrometry (LC‐MS/MS) is the primary analytical technique for this purpose; however, extensive backbone fragmentation ...
Paula Cifuentes, Albert Garriga, Fabien Fontaine, Ismael Zamora   +3 more
wiley   +1 more source

Stathmin-2 mediates paracrine hormone regulation of glucagon through lysosomal trafficking in αTC1-6 cells. [PDF]

J Physiol
Chang N, Ugulini S, Dhanvantari S.
europepmc   +1 more source

Biological activities and bioactive constituents of Flammulina velutipes: An updated systematic review

Journal of the Science of Food and Agriculture, Volume 106, Issue 14, Page 8298-8314, November 2026.
Abstract Flammulina velutipes (enokitake) is an edible mushroom recognized for both its nutritional and medicinal properties. It exhibits a broad spectrum of biological activities, including antioxidant, anti‐inflammatory, antitumor, immunomodulatory, and gut microbiota‐regulating effects.
Rıdvan Özgen, Didem Şöhretoğlu, Ayşe Kuruüzüm‐Uz   +2 more
wiley   +1 more source

Differential somatostatin sensitivity of corticotropic and somatotropic responses following amino acid infusion. [PDF]

Endocr Connect
Sturlaugsson Jóhönnuson EM, Reiche J, Richter MM, Wewer Albrechtsen NJ.   +3 more
europepmc   +1 more source

Cytological Identification of a Rhabdoid Variant of Pancreatic Neuroendocrine Neoplasm

Cytopathology, Volume 37, Issue 6, Page 641-647, November 2026.
Intracytoplasmic inclusions observed in rhabdoid‐type neuroendocrine tumours are evident on Giemsa staining and show strong cytokeratin (AE1/AE3) positivity on immunocytochemistry. This report describes the cytological features of a rare rhabdoid variant of pancreatic neuroendocrine neoplasm and highlights the diagnostic challenges associated with this
Miyu Okuda, Keishi Mizuguchi, Tatsuya Mori, Urara Okawa, Hiroko Ikeda   +4 more
wiley   +1 more source

Initiation of SGLT2 Inhibitors Versus DPP‐4 Inhibitors in Metformin Users and Risk of Incident Depression: A Nationwide, Claims‐Based Active‐Comparator New‐User Study

Diabetes, Obesity and Metabolism, Volume 28, Issue 11, Page 10765-10779, November 2026.
ABSTRACT Aims To examine the association between initiation of sodium‐glucose cotransporter‐2 (SGLT2) inhibitors and risk of incident depression compared with dipeptidyl peptidase‐4 (DPP‐4) inhibitors among adults with newly diagnosed Type 2 diabetes receiving metformin.
Sangwoo Park, Seogsong Jeong, Hye Jun Kim, Dae Ho Lee, Soo Jung Choi, Sang Min Park   +5 more
wiley   +1 more source

Sex-Dependent Effects of Exogenous Irisin on Pancreatic Endocrine-Cell Immunophenotype in Post-Weaning Wistar Rats. [PDF]

Curr Issues Mol Biol
Osiak-Wicha C, Manastyrska-Stolarczyk M, Muszyński S, Kras K, Dajnowska A, Janicka L, Woźniak K, Tomaszewska E, Słowik T, Dobrowolski P, Arciszewski MB.   +10 more
europepmc   +1 more source

Internalization of sst2, sst3, and sst5 receptors: effects of somatostatin agonists and antagonists

, 2006
The uptake of radiolabeled somatostatin analogs by tumor cells through receptor-mediated internalization is a critical process for the in vivo targeting of tumoral somatostatin receptors.
Eltschinger, Véronique, Rivier, Jean E, Schulz, Stefan, Reubi, Jean Claude, Cescato, Renzo, Waser, Beatrice, Liu, Qisheng, Wester, Hans-Jürgen, Culler, Michael, Ginj, Mihaela, Schonbrunn, Agnes   +10 more
core  

Systemic Bevacizumab for Severe Bleeding From Acquired Gastrointestinal Vascular Malformations

American Journal of Hematology, Volume 101, Issue 10, Page 2605-2615, October 2026.
Targeted antiangiogenic therapy with systemic bevacizumab for bleeding from acquired GI VMs was found to be safe and effective for chronic and severe bleeding from acquired vascular malformations due to idiopathic angiodysplasia, chronic liver disease, and deficiencies of von Willebrand factor, in a patient population comprised mostly of heavily ...
Nardeen E. Ayad, Jacob R. Anderson, Bimalangshu Dey, Rebecca Karp Leaf, Andrew B. Song, Hanny Al‐Samkari   +5 more
wiley   +1 more source