Results 41 to 50 of about 117,172 (212)
Somatostatin and Somatostatin Receptors in Tumour Biology
International Journal of Molecular Sciences, 2023 Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release from secretory or immune cells, the first most appreciated role that SST exhibits is the antiproliferative effect in target tissue that served as a potential therapeutic ...
openaire +2 more sources
Treatment options for PNET liver metastases. a systematic review [PDF]
, 2018 Pancreatic neuroendocrine tumors (PNETs) are rare pancreatic neoplasms. About 40-80% of patients with PNET are metastatic at presentation, usually involving the liver (40-93%). Liver metastasis represents the most significant prognostic factor.
Aurello, Paolo +8 more
core +1 more source
Long Acting Somatostatin Analogue: Clinical Potential for Gastrointestinal Disease
Canadian Journal of Gastroenterology, 1989 Name somatostatin is found throughout the gastrointestinal tract and has a wide variety of biological actions. Nevertheless, its short biological half-life and limited stability necessitate its use via continuous parenteral infusion and, thus, limits its
Richard N. Fedorak
doaj +1 more source
Expression of gastrin-releasing peptide by excitatory interneurons in the mouse superficial dorsal horn [PDF]
, 2014 Background: Gastrin-releasing peptide (GRP) and its receptor have been shown to play an important role in the sensation of itch. However, although GRP immunoreactivity has been detected in the spinal dorsal horn, there is debate about whether this ...
Gutierrez-Mecinas, Maria +2 more
core +1 more source
Ожирение и метаболизм, 2011 Octreotide is a synthetic analog of hypothalamic hormone somatostatin. This neuropeptide is widely distributed in humans and animals in central nervous system and periphery, which defines its potential regulatory functions. In 1987 the first registration
E A Pigarova, L K Dzeranova
doaj +1 more source
Frontiers in Endocrinology, 2020 Introduction: Acromegaly is a rare, serious endocrine disorder characterized by excess growth hormone (GH) secretion by a pituitary adenoma and overproduction of insulin-like growth factor I (IGF-I).
Mônica Gadelha +10 more
doaj +1 more source
Сахарный диабет, 2013 Aim. To study the distribution and cellular architecture of the largest human pancreatic islets (with a diameter of more than 200 micron) in aging and diabetes mellitus types 1 and 2. Materials and methods. Antibodies to insulin, glucagon, somastatin
Alexandra Evgen'evna Proshchina +3 more
doaj +1 more source
Somatostatin in gastroenterology [PDF]
BMJ, 1994 Somatostatin was isolated from ovine hypothalamus in 1973, and eight years later a long acting analogue, octreotide, was synthesised. More than 1000 clinical applications have since been suggested for these paninhibitory peptides, particularly in gastroenterology.
A, Shulkes, J S, Wilson
openaire +2 more sources
Archives of Endocrinology and MetabolismSUMMARY Hemangioblastomas associated with von Hippel-Lindau (VHL) disease are frequently multiple and recur during prolonged follow-up. Currently, no systemic treatment is available for these tumors.
Eloá Pereira Brabo +4 more
doaj +1 more source
, 2014 A novel radio guided surgery (RGS) technique for cerebral tumors using $\beta^{-}$ radiation is being developed. Checking the availability of a radio-tracer that can deliver a $\beta^{-}$ emitter to the tumor is a fundamental step in the deployment of ...
BELLINI, Fabio +23 more
core +1 more source