Results 41 to 50 of about 76,206 (274)

On implications of somatostatin in diabetic retinopathy

Neural Regeneration Research
Somatostatin, a naturally produced neuroprotective peptide, depresses excitatory neurotransmission and exerts anti-proliferative and anti-inflammatory effects on the retina.
Yanhong Fang, Qionghua Wang, Youjian Li, Li Zeng, Jian Liu, Kepeng Ou   +5 more
doaj   +1 more source

Melatonin mediates monochromatic light-induced expression of somatostatin in the hypothalamus and pituitary of chicks

Poultry Science, 2021
: Melatonin (MEL) plays an important role in regulating growth and development of organisms and the cellular metabolism. This study was conducted to explore the role of MEL in mediating monochromatic light-induced secretion of somatostatin (SST) in the ...
Xiaojing Qin, Xinfeng Liu, Xingyue Yan, Meizhen Long, Zixu Wang, Yulan Dong, Yaoxing Chen, Jing Cao   +7 more
doaj   +1 more source

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Regulatory Mechanisms of Somatostatin Expression [PDF]

, 2020
Somatostatin is a peptide hormone, which most commonly is produced by endocrine cells and the central nervous system. In mammals, somatostatin originates from pre-prosomatostatin and is processed to a shorter form, i.e., somatostatin-14, and a longer ...
Matthias W. Laschke, Michael D. Menger, Emmanuel Ampofo, Lisa Nalbach   +3 more
core   +2 more sources

Characterization of Oxytocin Receptor Expression Within Various Neuronal Populations of the Mouse Dorsal Hippocampus

Frontiers in Molecular Neuroscience, 2020
Oxytocin, acting through the oxytocin receptor (Oxtr) in the periphery, is best known for its roles in regulating parturition and lactation. However, it is also now known to possess a number of important social functions within the central nervous system,
W. Scott Young, June Song
doaj   +1 more source

Successful postoperative pancreatic fistula treatment with the use of somatostatin infusion after duodenal gastrointestinal stromal tumor resection [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2019
Introduction. According to the International Study Group on Pancreatic Fistula, a postoperative pancreatic fistula is defined as every case of fluid leak on the third (or later) postoperative day, in which the level of amylase in the collected fluid is ...
Chabowski Mariusz, Pawlowski Wiktor, Lesniak Michał, Ziomek Agnieszka, Malinowski Maciej, Dorobisz Tadeusz, Janczak Dariusz   +6 more
doaj   +1 more source

Accurately Deciphering Tissue Heterogeneity From Spatial Multi‐Modal and Multi‐Omics With STransformer

Advanced Science, EarlyView.
STransformer is a unified deep learning framework designed to seamlessly accommodate a comprehensive landscape of spatial data. By simultaneously capturing short‐range cellular interactions and tissue‐wide semantic patterns, it extracts robust representations to accurately dissect complex tissue heterogeneity.
Xingyi Li, Jialuo Xu, Gaoyuan Du, Xiangting Jia, Dongmin Zhao, Chunyan Zhou, Kexin Xiao, Jia Gu, Junnan Zhu, Xuequn Shang   +9 more
wiley   +1 more source

Comparative analysis of somatostatin analog uptake between successfully irradiated and non-irradiated meningiomas

Einstein (São Paulo), 2022
Objective To evaluate whether there is a significant difference in somatostatin analog uptake in meningiomas treated or not with radiation therapy.
Guilherme de Carvalho Campos Neto, Edson Amaro Junior, Eduardo Weltman, Suzana Maria Fleury Malheiros, Bruna Letícia Ferrari, Taise Vitor, Marycel Rosa Felisa Figols de Barboza, Rosemeire Pereira Bezerra, Lilian Yuri Itaya Yamaga, Jairo Wagner, Ronaldo Hueb Baroni   +10 more
doaj   +1 more source

Targeting Lipopolysaccharide Transport Induces Membrane Lipid Remodeling and Sensitizes Acinetobacter baumannii to Colistin Treatment

Advanced Science, EarlyView.
This study identifies C4 as a lead inhibitor of the Lpt system. Notably, C4 potentiates colistin activity by disrupting LPS transport and remodeling phospholipid homeostasis, revealing a functional interplay between the Lpt and Mla systems. These findings establish a mechanistic link between Lpt inhibition and membrane lipid remodeling, positioning Lpt–
Jianya Luo, Hetianzi Zhang, Jinju Cai, Shuang Zhou, Haijie Zhang, Zhiqiang Wang, Yuan Liu   +6 more
wiley   +1 more source

Somatostatin receptor subtype 2A immunohistochemistry using a new monoclonal antibody selects tumors suitable for in vivo somatostatin receptor targeting

, 2012
High overexpression of somatostatin receptors in neuroendocrine tumors allows imaging and radiotherapy with radiolabeled somatostatin analogues. To ascertain whether a tumor is suitable for in vivo somatostatin receptor targeting, its somatostatin ...
Waser, Beatrice, Reubi, Jean, Körner, Meike, Schonbrunn, Agnes, Perren, Aurel   +4 more
core   +1 more source