Results 31 to 40 of about 76,206 (274)

Sandostatin i Sandostatin LAR pri metabolicheskikh, neyroendokrinnykh i onkologicheskikh zabolevaniyakh

Ожирение и метаболизм, 2011
Octreotide is a synthetic analog of hypothalamic hormone somatostatin. This neuropeptide is widely distributed in humans and animals in central nervous system and periphery, which defines its potential regulatory functions. In 1987 the first registration
E A Pigarova, L K Dzeranova
doaj   +1 more source

Evaluation of the Efficacy and Safety of Switching to Pasireotide in Patients With Acromegaly Inadequately Controlled With First-Generation Somatostatin Analogs

Frontiers in Endocrinology, 2020
Introduction: Acromegaly is a rare, serious endocrine disorder characterized by excess growth hormone (GH) secretion by a pituitary adenoma and overproduction of insulin-like growth factor I (IGF-I).
Mônica Gadelha, Marie Bex, Annamaria Colao, Elier Mitsael Pedroza García, Catalina Poiana, Marisela Jimenez-Sanchez, Serkan Yener, Rishav Mukherjee, Amy Bartalotta, Ricardo Maamari, Gérald Raverot   +10 more
doaj   +1 more source

The Role of Somatostatin Treatment in the Management of Chylous Fistula after Neck Dissection [PDF]

, 2014
Chylous fistula is a serious complication of neck dissection. The use of somatostatin after neck surgery, has been described in literature. Because of the absence of definitive guidelines, reporting of our experience in three cases may guide the surgeons
Metin Demircin, Ali Şefik Hoşal, DEMİRCİN, METİN, Bülent Sözeri, Nilda Süslü, SÜTAY SÜSLÜ, NİLDA, Sozeri, Bulent, HOŞAL, ALİ ŞEFİK   +7 more
core   +1 more source

Immunohystochemical study of the largest islets of human pancreas in aging and diabetes mellitus: perspectives for the transplantation

Сахарный диабет, 2013
Aim.  To study the distribution and cellular architecture of the largest human pancreatic islets (with a diameter of more than 200 micron) in aging and diabetes mellitus types 1 and 2. Materials and methods.  Antibodies to insulin, glucagon, somastatin
Alexandra Evgen'evna Proshchina, Yulia Sergeevna Krivova, Valeriy Mikhaylovich Barabanov, Sergey Vyacheslavovich Savelyev   +3 more
doaj   +1 more source

Expression of somatostatin receptors in hemangioblastomas associated with von Hippel-Lindau disease as a novel diagnostic, therapeutic, and follow-up opportunity: A case report and literature review

Archives of Endocrinology and Metabolism
SUMMARY Hemangioblastomas associated with von Hippel-Lindau (VHL) disease are frequently multiple and recur during prolonged follow-up. Currently, no systemic treatment is available for these tumors.
Eloá Pereira Brabo, Sergio Altino de Almeida, Patrícia Piazza Rafful, Paulo Henrique Rosado-de-Castro, Leonardo Vieira Neto   +4 more
doaj   +1 more source

Somatostatin in gastroenterology [PDF]

BMJ, 1994
Somatostatin was isolated from ovine hypothalamus in 1973, and eight years later a long acting analogue, octreotide, was synthesised. More than 1000 clinical applications have since been suggested for these paninhibitory peptides, particularly in gastroenterology.
A, Shulkes, J S, Wilson
openaire   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

A Tyrosine Phosphatase is Associated with the Somatostatin Receptor

, 2007
Regulation of tyrosine phosphorylation is thought to be an essential step in signal transduction mechanisms that mediate cellular responses. In pancreatic tumour cells we demonstrated that somatostatin analogues inhibited cell proliferation and ...
M. Zeggari, Vaysse, N, Zeggari, M, L. Buscail, C. Susini, Estève, J. P, N. Delesque, Saint‐Laurent, N, Susini, C, Rauly, I, N. Vaysse, Buscail, L, Bell, G. I, N. Saint-Laurent, I. Rauly, A. V. Schally, Schally, A. V, J. P. Estève, Delesque, N, G. I. Bell   +19 more
core   +1 more source

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Diffuse somatostatin-immunoreactive D-cell hyperplasia in the stomach and duodenum [PDF]

, 1986
This paper presents the first case of extensive, diffuse, somatostatin- immunoreactive D-cell hyperplasia in the human stomach and duodenum. It occurred in a 37-yr-old woman, who showed clinical signs of dwarfism, obesity, dryness of the mouth, and ...
Eisenmenger, Wolfgang, Pradayrol, L., Spann, W., Riedel, J., Holle, G. E.   +4 more
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