Results 11 to 20 of about 76,206 (274)

Somatostatin receptors

American Journal of Physiology-Gastrointestinal and Liver Physiology, 1995
Somatostatin induces its biological actions by activating a family of receptor subtypes. The recent cloning of five somatostatin receptor subtypes has led to the development of subtype-selective agonists. These compounds are revealing distinct functions of the individual receptor subtypes.
T. Reisine
openaire   +3 more sources

Somatostatin and somatostatin receptors in retinal diseases [PDF]

European Journal of Endocrinology, 2000
Somatostatin is a small neuropeptide that is producedin the central nervous system, where it acts as aneurotransmitter. This neuropeptide also has animportant role in the neuroendocrine system as aninhibitor of hormone release, the most strikingexample of which is the inhibition of growth hormonerelease.
van, Hagen PM, Baarsma, GS, Mooy, CM, Ercoskan, EM, ter, Averst E, Hofland, LJ, Lamberts, SW, Kuijpers, RW   +7 more
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Somatostatin subtype-2 receptor-targeted metal-based anticancer complexes [PDF]

, 2012
Conjugates of a dicarba analogue of octreotide, a potent somatostatin agonist whose receptors are overexpressed on tumor cells, with [PtCl 2(dap)] (dap = 1-(carboxylic acid)-1,2-diaminoethane) (3), [(η 6-bip)Os(4-CO 2-pico)Cl] (bip = biphenyl, pico ...
González, Carlos A., Moreno Martínez, Virtudes, Carrion-Salip, Dolors, González-Cantó, A., Massaguer, A., Sadler, Peter, Llorens Duran, Rafael de, Massaguer i Vall-llovera, Anna, González Ibañez, Carlos, Massaguer, Anna, de Llorens, Rafael, Carrion-Salip, D, González, Carlos, Gómez-Pinto, Irene, Sadler, P. J., Moreno, Virtudes, Barragán, F., Barragán, Flavia, Sadler, P.J., Llorens, Rafael de, Marchán Sancho, Vicente, Sadler, Peter J., Carrion Salip, Dolors, Marchán, Vicente, González-Cantó, Alejandro   +24 more
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Reduced brain somatostatin in mood disorders: a common pathophysiological substrate and drug target?

Frontiers in Pharmacology, 2013
Our knowledge of the pathophysiology of affect dysregulation has progressively increased, but the pharmacological treatments remain inadequate. Here, we summarize the current literature on deficits in somatostatin, an inhibitory modulatory neuropeptide ...
Li-Chun eLin, Etienne eSibille
doaj   +1 more source

Somatostatin in the rat periventricular nucleus: sex differences and effect of gonadal steroids [PDF]

, 2008
In the rat, the sexual dimorphism in growth hormone release is driven by sex steroids, and is suggested to result mainly from differences in somatostatin (SOM) release patterns from the median eminence.
Van de Heijning, Bert J M, Van Vugt, Harmke H, Harmke H. Van Vugt, Bert J. M. Van de Heijning, van der Beek, E.M., van Vugt, H.H., Vugt, H.H., van, Beek, E.M., van der, Van der Beek, Eline M; id_orcid, Van der Beek, Eline M, van de Heijning, B.J.M., Heijning, B.J.M., van de, Eline M. Van der Beek   +12 more
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The therapeutic effect of the neuropeptide hormone somatostatin on Schistosoma mansoni caused liver fibrosis

BMC Infectious Diseases, 2005
Background The neuropeptide somatostatin is one of the major regulatory peptides in the central nervous system and the digestive tract. Our recent work has delineated an association between fibrosis and low levels of endogenous somatostatin plasma levels
Peeters Theo, Depoortere Inge, Vrolix Gunther, Chatterjee Shyama, Van Marck Eric   +4 more
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Bulk and Single-Nucleus Transcriptomics Highlight Intra-Telencephalic and Somatostatin Neurons in Alzheimer’s Disease

Frontiers in Molecular Neuroscience, 2022
Cortical neuron loss is a pathological hallmark of late-onset Alzheimer’s disease (AD). However, it remains unclear which neuronal subtypes beyond broad excitatory and inhibitory classes are most vulnerable.
Micaela E. Consens, Yuxiao Chen, Vilas Menon, Vilas Menon, Yanling Wang, Julie A. Schneider, Philip L. De Jager, Philip L. De Jager, David A. Bennett, Shreejoy J. Tripathy, Shreejoy J. Tripathy, Shreejoy J. Tripathy, Shreejoy J. Tripathy, Daniel Felsky, Daniel Felsky, Daniel Felsky, Daniel Felsky   +16 more
doaj   +1 more source

The decrease in growth hormone (GH) response after repeated stimulation with GH-Releasing hormone is partly caused by an elevation of somatostatin tonus. [PDF]

, 1996
Repeated injection of GHRH leads to a decrease in the GH response in normal subjects. Arginine (Arg) stimulates GH secretion by suppression of hypothalamic somatostatin.
Schopohl, Jochen, Schrader, Monika, Mehltretter, Gerhard, Müller, Otto-Albrecht, Reichardt, Bärbel, Mojto, Juraj   +5 more
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Therapeutic effects of Bombax ceiba flower aqueous extracts against loperamide-induced constipation in mice

Pharmaceutical Biology, 2023
Context Bombax ceiba Linnaeus (Bombacaceae) is known as silk cotton tree, the flowers of which are used in many medicinal applications.Objective To investigate the therapeutic effect of B.
Liuping Wang, Shiyuan Xie, Xuan Jiang, Caini Xu, Youqiong Wang, Jianfang Feng, Bin Yang   +6 more
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Approach of Acromegaly during Pregnancy

Diagnostics, 2022
Acromegaly-related sub/infertility, tidily related to suboptimal disease control (1/2 of cases), correlates with hyperprolactinemia (1/3 of patients), hypogonadotropic hypogonadism—mostly affecting the pituitary axis in hypopituitarism (10–80%), and ...
Alexandru Dan Popescu, Mara Carsote, Ana Valea, Andreea Gabriela Nicola, Ionela Teodora Dascălu, Tiberiu Tircă, Jaqueline Abdul-Razzak, Mihaela Jana Țuculină   +7 more
doaj   +1 more source