Results 51 to 60 of about 76,206 (274)

Pharmacologic inhibition of somatostatin receptor 2 to restore glucagon counterregulation in diabetes

Frontiers in Pharmacology
Glucose homeostasis is primarily maintained by pancreatic hormones, insulin and glucagon, with an emerging role for a third islet hormone, somatostatin, in regulating insulin and glucagon responses.
Emily G. Hoffman, Ninoschka C. D’Souza, Richard T. Liggins, Michael C. Riddell   +3 more
doaj   +1 more source

North American Delphi Consensus Study on Sinonasal Malignancy Survivorship Care

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Survival for patients with sinonasal cancers has improved over the past decades, but there are no dedicated survivorship guidelines for this cohort. Objective To understand experts’ priorities and perspectives on key survivorship tenets (surveillance, second tumor screening, toxicity, and symptom management).
Matheus Sewastjanow‐Silva, Samagra Jain, Rita Snyder, Erin L. McKean, Ralph Abi Hachem, Nithin D. Adappa, J. Ken Byrd, Ricardo L. Carrau, Marc A. Cohen, Ivan H. El‐Sayed, Mathew N. Geltzeiler, Ehab Y. Hanna, Edward C. Kuan, Nyall R. London Jr., Zoukaa B. Sargi, Carl H. Snyderman, Marilene B. Wang, Ian J. Witterick, Shirley Y. Su   +18 more
wiley   +1 more source

Funktionalisierung von Peptiden auf der festen Phase im späten Synthesestadium

Angewandte Chemie, EarlyView.
Peptidmodifikationen sind für die Kontrolle der Eigenschaften von Peptidwirkstoffen von entscheidender Bedeutung. Daher sind Strategien, die einen effizienten und schnellen Einbau nicht‐kanonischer Modifikationen in Peptide in Parallelformaten ermöglichen, sehr gefragt.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Illuminating somatostatin analog action at neuroendocrine tumor receptors

, 2013
Somatostatin analogs for the diagnosis and therapy of neuroendocrine tumors (NETs) have been used in clinical applications for more than two decades.
Reubi, Jean-Claude, Schonbrunn, Agnes
core   +1 more source

Somatostatin and Neuropeptide Y in Cerebrospinal Fluid: Correlations With Amyloid Peptides Aβ1–42 and Tau Proteins in Elderly Patients With Mild Cognitive Impairment

Frontiers in Aging Neuroscience, 2018
A combination of low cerebrospinal fluid (CSF) Amyloid β1–42 (Aβ1–42) and high Total-Tau (T-Tau) and Phosphorylated-Tau (P-Tau) occurs at a prodromal stage of Alzheimer’s disease (AD) and recent findings suggest that network abnormalities and ...
Emmanuelle Duron, Emmanuelle Duron, Emmanuelle Duron, Emmanuelle Duron, Jean-Sébastien Vidal, Jean-Sébastien Vidal, Dominique Grousselle, Audrey Gabelle, Sylvain Lehmann, Florence Pasquier, Stéphanie Bombois, Luc Buée, Bernadette Allinquant, Susanna Schraen-Maschke, Susanna Schraen-Maschke, Christiane Baret, Anne-Sophie Rigaud, Anne-Sophie Rigaud, Olivier Hanon, Olivier Hanon, Jacques Epelbaum, Jacques Epelbaum   +21 more
doaj   +1 more source

Recent advances in neuropeptide-related omics and gene editing: Spotlight on NPY and somatostatin and their roles in growth and food intake of fish

Frontiers in Endocrinology, 2022
Feeding and growth are two closely related and important physiological processes in living organisms. Studies in mammals have provided us with a series of characterizations of neuropeptides and their receptors as well as their roles in appetite control ...
Xiaozheng Yu, Haijun Yan, Wensheng Li
doaj   +1 more source

Hippocampal Somatostatin Interneurons, Long-Term Synaptic Plasticity and Memory

Frontiers in Neural Circuits, 2021
A distinctive feature of the hippocampal structure is the diversity of inhibitory interneurons. These complex inhibitory interconnections largely contribute to the tight modulation of hippocampal circuitry, as well as to the formation and coordination of
Eve Honoré, Abdessattar Khlaifia, Anthony Bosson, Jean-Claude Lacaille   +3 more
doaj   +1 more source

Late‐Stage Functionalization of Peptides on the Solid Phase

Angewandte Chemie International Edition, EarlyView.
Peptide modifications are essential to control pharmacodynamic and pharmacokinetic properties of peptide drugs. Consequently, strategies that allow for efficient and rapid incorporation of non‐canonical modifications into peptides in parallel formats are highly sought after.
Marius Werner, Truc Lam Pham, Franziska Thomas   +2 more
wiley   +1 more source

Effect of Intraduodenal Bile and Taurodeoxycholate on Exocrine Pancreatic Secretion and on Plasma Levels of Vasoactive Intestinal Polypeptide and Somatostatin in Man [PDF]

, 1994
Intraduodenal (i.d.) application of bile or Na-taurodeoxycholate (TDC) dose dependently enhances basal exocrine pancreatic secretion. The hydrokinetic effect is mediated at least in part by secretin.
Teufel, Johannes, Riepl, Rudolf L., Fiedler, Fritz, Lehnert, Peter   +3 more
core  

Radiolabelled somatostatin analogue scintigraphy in oncology

, 1996
Somatostatin analogue scintigraphy represents a new technique employing radiolabelled peptides to detect specific receptor-bearing lesions. 111Indium diethylenetriaminopentaacetic acid-linked octreotide (111In-DTPA-D-Phe1 octreotide), also known as ...
Carney, Desmond N., O'Byrne, Kenneth J.
core   +1 more source