Results 71 to 80 of about 74,951 (264)

A new radiolabelled somatostatin analogue [111In-DTPA-D-Phe1]RC-160: preparation, biological activity, receptor scintigraphy in rats and comparison with [111In-DTPA-D-Phe1]octreotide [PDF]

, 1994
We have evaluated the potential usefulness of indium-111 labelled [DTPA-D-Phe1]RC-160, derived from the octapeptide somatostatin analogue RC-160, as a radiopharmaceutical for the in vivo detection of somatostatin receptor-positive tumours.
Bakker, W.H. (Willem), Breeman, W.A.P. (Wouter), Hofland, L.J. (Leo), Jong, M. (Marcel) de, Koetsveld, P.M. (Peter) van, Krenning, E.P. (Eric), Kwekkeboom, D.J. (Dirk Jan), Lamberts, S.W.J. (Steven), Pluijm, M. (M.) van der, Setyono-Han, B. (Buddy), Visser, T.J. (Theo)   +10 more
core   +1 more source

Deep Brain Stimulation Induces Antidepressant Effects by Restoring High‐Fidelity Communication in the BNST‐NAc Circuit

Advanced Science, EarlyView.
This cross‐species study reveals that pathological hyperactivity of BNST neurons in depressive states disrupts inhibitory period and isolated spikes in the BNST‐NAc circuit. DBS achieves its antidepressant effects by precisely restoring network inhibitory periods and high‐fidelity signal transmission.
Xin Lv, Yu Cao, Yuhan Wang, Yunhao Wu, Yingying Zhang, Kuanghao Ye, Xian Qiu, Qingfang Sun, Liuguan Bian, Halimureti Paerhati, Valerie Voon, Shikun Zhan, Bomin Sun   +12 more
wiley   +1 more source

An Update on DOTA-Peptides PET Imaging and Potential Advancements of Radioligand Therapy in Intracranial Meningiomas

Life
Meningiomas arise from the meningeal layers covering the central nervous system structures. Although most are benign, meningiomas can still cause neurological morbidity due to the mass effect and compression of the surrounding parenchyma.
Viviana Benfante, Ignazio Gaspare Vetrano, Muhammad Ali, Pierpaolo Purpura, Cesare Gagliardo, Paola Feraco, Costanza Longo, Tommaso Vincenzo Bartolotta, Patrizia Toia, Oriana Calisto, Albert Comelli, Massimo Midiri, Pierpaolo Alongi   +12 more
doaj   +1 more source

Role of cyclic AMP in the control of cell-specific gene expression [PDF]

, 1993
Genes have to be expressed in specific cell types at appropriate times of development dependent on external signals. cAMP signaling occurs in all cells, thus raising the question of how this signal transduction pattern is integrated into mechanisms ...
Boshart, Michael, Nitsch, Doris, Schmid, Wolfgang, Schütz, Günther   +3 more
core   +1 more source

Somatostatin Receptor 2–Targeting Compounds [PDF]

Journal of Nuclear Medicine, 2017
The molecular imaging and treatment of neuroendocrine tumors (NETs) with radiolabeled somatostatin analogs represent a milestone in the development of theranostic compounds. Whole-body scintigraphy with 111In-pentetreotide has revolutionized the diagnosis and staging of NETs and the evaluation of treatment outcomes. At present, diagnostic accuracy with
Smit Duijzentkunst, Daniël, Kwekkeboom, Dik, Bodei, L   +2 more
openaire   +3 more sources

Preoperative Aortic Calcification Volume Predicts Postoperative Complications in Nonpancreatic Cancer Patients Undergoing Pancreaticoduodenectomy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background/Objectives Postoperative complications following pancreaticoduodenectomy (PD) remain high, particularly in patients with soft pancreatic texture. Abdominal aortic calcification volume (AACV), a surrogate marker of systemic arteriosclerosis, has been associated with increased surgical risk in lower gastrointestinal procedures ...
Masaki Horiuchi, Kentaro Miyake, Kota Sahara, Jun Yamamoto, Yutaro Kikuchi, Yasuhiro Yabushita, Yu Sawada, Yuki Homma, Ryusei Matsuyama, Itaru Endo   +9 more
wiley   +1 more source

Contemporary nuclear medicine diagnostics of neuroendocrine tumors [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2015
The new positron emission tomography (PET/CT) methods for neuroendocrine tumors detection are presented and compared with classic, conventional methods. Conventional methods use a gamma scintillation camera for patients with neuroendocrine tumor
Todorović-Tirnanić Mila, Artiko Vera, Pavlović Smiljana, Šobić-Šaranović Dragana, Obradović Vladimir   +4 more
doaj   +1 more source

Critical role of somatostatin receptor 2 in the vulnerability of the central noradrenergic system: new aspects on Alzheimer's disease [PDF]

, 2015
Alzheimer's disease and other age-related neurodegenerative disorders are associated with deterioration of the noradrenergic locus coeruleus (LC), a probable trigger for mood and memory dysfunction.
Adori, C., Barde, S., Bölcskei, Kata, Gluck, L., Kovacs, G. G., Maglóczky, Zsófia, Palkovits, Miklós, Szolcsányi, János, Yoshitake, T.   +8 more
core   +1 more source

Somatostatin and Somatostatin Receptors in Tumour Biology

International Journal of Molecular Sciences, 2023
Somatostatin (SST), a growth hormone inhibitory peptide, is expressed in endocrine and non-endocrine tissues, immune cells and the central nervous system (CNS). Post-release from secretory or immune cells, the first most appreciated role that SST exhibits is the antiproliferative effect in target tissue that served as a potential therapeutic ...
openaire   +2 more sources

Functional Segregation of Epileptogenicity within the Human Amygdala

Annals of Neurology, EarlyView.
Objective In temporal lobe epilepsy (TLE), the amygdala in the epileptogenic network is underestimated compared to other regions such as the hippocampus. Recent advances in anatomical neuroimaging and stereoelectroencephalography (SEEG) signal analyses could help better understand the involvement of the different amygdala nuclei in the genesis of ...
Odile Feys, Julia Makhalova, Samuel Medina Villalon, Maria Fratello, Hugo Dary, Stanislas Lagarde, Francesca Pizzo, Agnès Trébuchon, Maxime Guye, Jean‐Philippe Ranjeva, Romain Carron, Didier Scavarda, Christian‐George Bénar, Bernard Giusiano, Fabrice Bartolomei   +14 more
wiley   +1 more source