Results 21 to 30 of about 1,664 (165)

Persistence with daily growth hormone among children and adolescents with growth hormone deficiency in the UK

Frontiers in Endocrinology, 2022
BackgroundChildren with growth hormone deficiency (GHD) are treated with daily somatropin injections; however, poor treatment persistence and adherence have been recognized previously and have been shown to negatively impact growth outcomes.
Jane Loftus, Jen Wogen, David Oliveri, Darrin Benjumea, Priti Jhingran, Yong Chen, Jose Alvir, Elena Rivero-Sanz, Jack C. Kowalik, Michael P. Wajnrajch, Michael P. Wajnrajch   +10 more
doaj   +1 more source

Somatropin therapy in italian adults with growth hormone deficiency

BMC Endocrine Disorders, 2022
Background In adult population, Growth Hormone Deficiency (GHD) is a complex clinical condition with heterogeneity of causes and duration. Growth Hormone (GH) replacement therapy has beneficial effects entailing a chronic and expensive use.
Flavia Pricci, Daniela Rotondi, Marika Villa, Arianna Valerio, Elvira Agazio, Paolo Roazzi   +5 more
doaj   +1 more source

Efficacy and Safety of Weekly Somatrogon vs Daily Somatropin in Children With Growth Hormone Deficiency: A Phase 3 Study [PDF]

, 2022
Context: Somatrogon is a long-acting recombinant human growth hormone (rhGH) in development for once-weekly treatment of children with growth hormone deficiency (GHD). Objective: We aimed to compare the efficacy and safety of once-weekly somatrogon with
김호성, Elpis Vlachopapadopoulou, Oleg Malievskiy, Bradley S Miller, Moshe Phillip, Valluri, Srinivas Rao, Ho-Seong Kim, Deal, Cheri L, Vlachopapadopoulou, Elpis, Lawrence A Silverman, CheolWoo Ko, Phillip, Moshe, Taylor, Carrie Turich, Wajnrajch, Michael P, Carl L Roland, Aleksandra Pastrak, Srinivas Rao Valluri, Cara, Jose F, Renata Stawerska, Miller, Bradley S, Malievskiy, Oleg, Carrie Turich Taylor, Pastrak, Aleksandra, Silverman, Lawrence A, Stawerska, Renata, Kim, Ho-Seong, Ko, CheolWoo, Jose F Cara, Michael P Wajnrajch, Cheri L Deal, Joel Steelman, Roland, Carl L, Steelman, Joel   +32 more
core   +1 more source

Physician experience with once-weekly somatrogon versus once-daily rhGH regimen in pediatric patients with growth hormone deficiency: a cross-sectional survey of physicians from the global phase 3 study

Frontiers in Endocrinology, 2023
IntroductionThe standard of care for pediatric growth hormone deficiency (pGHD) is once-daily recombinant human growth hormone (rhGH). Somatrogon, a long-acting rhGH, requires less frequent, once-weekly, dosing.
Roy Gomez, Roger Lamoureux, Diane M. Turner-Bowker, Jane Loftus, Mohamad Maghnie, Mohamad Maghnie, Bradley S. Miller, Michel Polak, Andrew Yaworsky   +8 more
doaj   +1 more source

A Randomized Controlled Phase 3 Study on the Efficacy and Safety of Recombinant Human Growth Hormone in Children With Idiopathic Short Stature

Frontiers in Endocrinology, 2022
BackgroundTo evaluate the safety and efficacy of daily somatropin (Jintropin®), a recombinant human growth hormone, in prepubertal children with ISS in China.MethodsThis study was a multicenter, randomized, controlled, open-label, phase 3 study.
Jinna Yuan, Junfen Fu, Haiyan Wei, Gaixiu Zhang, Yanfeng Xiao, Hongwei Du, Wei Gu, Yanhong Li, Linqi Chen, Feihong Luo, Yan Zhong, Haihong Gong   +11 more
doaj   +1 more source

Pattern of Use of Biosimilar and Originator Somatropin in Italy: A Population-Based Multiple Databases Study During the Years 2009–2014

Frontiers in Endocrinology, 2018
PurposeSomatropin [recombinant growth hormone (rGH)] is approved in children and adults for several conditions involving growth disturbances and the corresponding biosimilar is available in Italy since 2006.
Ilaria Marcianò, Ylenia Ingrasciotta, Francesco Giorgianni, Valentina Ientile, Alessandro Chinellato, Daniele Ugo Tari, Rosa Gini, Salvatore Cannavò, Maurizio Pastorello, Salvatore Scondotto, Pasquale Cananzi, Giuseppe Traversa, Francesco Trotta, Valeria Belleudi, Antonio Addis, Gianluca Trifirò, Gianluca Trifirò, Gianluca Trifirò   +17 more
doaj   +1 more source

Efficacy and Safety of Once-Weekly Lonapegsomatropin in Adults With Growth Hormone Deficiency: foresiGHt Trial Results. [PDF]

J Clin Endocrinol Metab
Adult growth hormone (GH) deficiency (GHD) is characterized by metabolic abnormalities caused by insufficient GH production. Lonapegsomatropin, a prodrug administered once weekly, was designed to provide sustained release of unmodified somatropin to ...
Biller BMK, Gilis-Januszewska A, Doknic M, Pico AM, Fleseriu M, Raverot G, Isidori AM, Takahashi Y, Garcia JM, Silverstein JM, Bancos I, Fukuoka H, Huang E, Kang J, Komirenko AS, Domrzalski L, Shu AD, Beckert M, Yuen KCJ.   +18 more
europepmc   +2 more sources

Blood-brain barrier transport kinetics of NOTA-modified proteins : the somatropin case [PDF]

, 2020
BACKGROUND: Chemical modifications such as PEG, polyamine and radiolabeling on proteins can alter their pharmacokinetic behaviour and their blood-brain barrier (BBB) transport characteristics. NOTA, i.e. 1,4,7-triazacyclononane-1,4,7-triacetic acid, is a
Bracke, Nathalie, De Spiegeleer, Bart, Sathekge, Mike, Janssens, Yorick, Maes, Alex, Tack, Liesa, Wynendaele, Evelien, Van De Wiele, Christophe   +7 more
core   +1 more source

Fatal overdose from injection of human growth hormone; a case report and review of the literature

BMC Endocrine Disorders, 2022
Background Human growth hormone (HGH) is a categorized as a performance-enhancing substance. HGH has been abused by athletes for doping purposes. Case presentation We present a first lethal case of HGH acute toxicity.
Azam Erfanifar, Mahsa Mahjani, Sepehr Gohari, Hossein Hassanian-Moghaddam   +3 more
doaj   +1 more source

Biological characterisation of somatropin-derived cryptic peptides [PDF]

, 2019
Little is known about possible cryptic peptides of the recombinant growth hormone (somatropin). In this study, six synthetic somatropin-derived peptides (SDPs) were selected based on their sequences which correspond to the binding interface of the growth
Bracke, Nathalie, De Spiegeleer, Bart, Sathekge, Mike, Van de Wiele, Christophe, Verbeke, Frederick, Maes, Alex, Tack, Liesa, Wynendaele, Evelien, Pauwels, Ewald, Sathekge, Mike Machaba   +9 more
core   +1 more source