Results 21 to 30 of about 1,206 (142)

Development of Competitive ELISAs Suitable for Detection of Recombinant Human Growth Hormone in Illegal Nutritional Supplements. [PDF]

J Anal Methods Chem
The use of human growth hormone (hGH) by athletes remains widespread despite being banned by the World Anti‐Doping Agency (WADA). Current commercial ELISA kits for the determination of hGH are predominantly based on the sandwich format of this method, which allows the analysis of the whole hGH molecules, but not their fragments.
Karamonová L, Procházková B, Volný M, Nemeškalová A, Sýkora D, Kuchař M, Fukal L, Holubová B.   +7 more
europepmc   +2 more sources

X-Linked Hypophosphatemia Caused by a New Partial Insertion of LINE-1 in the <i>PHEX</i> Gene. [PDF]

Hum Mutat
X‐linked hypophosphatemia (XLH), primarily caused by mutations of the PHEX gene, is the most common cause of genetic rickets. Pediatric cases of XLH typically present with elevated levels of serum fibroblast growth factor 23 (FGF23), hypophosphatemia, rickets, and impaired growth.
Li D, Peng W, Kang L, Geng J, Lu Y, Lu J.   +5 more
europepmc   +2 more sources

Pattern of Use of Biosimilar and Originator Somatropin in Italy: A Population-Based Multiple Databases Study During the Years 2009–2014

Frontiers in Endocrinology, 2018
PurposeSomatropin [recombinant growth hormone (rGH)] is approved in children and adults for several conditions involving growth disturbances and the corresponding biosimilar is available in Italy since 2006.
Ilaria Marcianò, Ylenia Ingrasciotta, Francesco Giorgianni, Valentina Ientile, Alessandro Chinellato, Daniele Ugo Tari, Rosa Gini, Salvatore Cannavò, Maurizio Pastorello, Salvatore Scondotto, Pasquale Cananzi, Giuseppe Traversa, Francesco Trotta, Valeria Belleudi, Antonio Addis, Gianluca Trifirò, Gianluca Trifirò, Gianluca Trifirò   +17 more
doaj   +1 more source

Fatal overdose from injection of human growth hormone; a case report and review of the literature

BMC Endocrine Disorders, 2022
Background Human growth hormone (HGH) is a categorized as a performance-enhancing substance. HGH has been abused by athletes for doping purposes. Case presentation We present a first lethal case of HGH acute toxicity.
Azam Erfanifar, Mahsa Mahjani, Sepehr Gohari, Hossein Hassanian-Moghaddam   +3 more
doaj   +1 more source

Budget Impact Analysis of Biosimilar Products in Spain in the Period 2009–2019

Pharmaceuticals, 2021
Since the first biosimilar medicine, Omnitrope® (active substance somatropin) was approved in 2006, 53 biosimilars have been authorized in Spain. We estimate the budget impact of biosimilars in Spain from the perspective of the National Health System ...
Manuel García-Goñi, Isabel Río-Álvarez, David Carcedo, Alba Villacampa   +3 more
doaj   +1 more source

Sever’s Disease in a Patient Receiving Growth Hormone with no Causative Relation [PDF]

Journal of Clinical and Diagnostic Research, 2018
Growth Hormone (GH) shows its main effect on bones and muscle tissues. There are reports of orthopaedic complications including carpal tunnel syndrome, Legg-Calve-Perthe’s disease, scoliosis, and slipped capital femoral epiphysis with GH use in the ...
Erdal Kurnaz, Senay Savas-Erdeve, Zehra Aycan, Semra Çetinkaya   +3 more
doaj   +1 more source

ACAN Pathogenic Variant as a Cause of Short Stature

Portuguese Journal of Pediatrics, 2023
Pathogenic variants of the aggrecan (ACAN) gene have been associated with a wide spectrum of growth modifications ranging from idiopathic short stature to severe skeletal dysplasia.
Diana Reis Monteiro, Miguel Leão, Maria Adriana Rangel, Rosa Arménia Campos, Ana Luísa Leite   +4 more
doaj   +1 more source

Designing a Personalized Digital Patient Support Program for Patients Treated With Growth Hormone: Key Design Considerations

Journal of Medical Internet Research, 2020
BackgroundRecombinant human growth hormone treatment can optimize growth potential; however, optimal outcomes are not always achieved for several reasons, including poor adherence.
Malik, Sumaira, Moloney, Clare, Koledova, Ekaterina, Reston, Jonathan, Weinman, John   +4 more
doaj   +1 more source

Assessment of Parental Satisfaction with the Treatment of Human Recombinant Growth Hormone in Children with Hypopituitarism

Pielęgniarstwo Neurologiczne i Neurochirurgiczne, 2021
Introduction. Growth depends on genetic, metabolic and also hormonal factors. Growth depends on health, the supply of nutrients and a properly functioning nervous system.
Lech Grzelak, Anna Wiśniewska
doaj   +1 more source

Simultaneous electrochemical investigation and detection of two glucocorticoids; interactions with human growth hormone, somatropin

Results in Chemistry, 2022
In the present work, the simultaneous determination of dexamethasone (DXM) and hydrocortisone (HYD) is described by the use of a nano-porous glassy carbon electrode (GCE), prepared via an electrochemical treatment.
Giti Paimard, Mojtaba Shamsipur, Mohammad Bagher Gholivand, Mohsen Shahlaei   +3 more
doaj   +1 more source