Results 31 to 40 of about 1,206 (142)

Peculiarities of Lipid Spectrum in Children with short stature [PDF]

open access: yesСаратовский научно-медицинский журнал, 2010
The research goal is to examine the lipid spectrum and to evaluate the effectiveness of somatropin therapy for correcting metabolic disorders in children with various forms of short stature.
Kopytina E.V.
doaj  

Self-reported vs electronically-recorded adherence to GH therapy

open access: yesRevista Colombiana de Endocrinología, Diabetes y Metabolismo, 2022
Introduction: Adherence to the prescribed injection schedule is critical for the success of treatment of growth disorders with recombinant human growth hormone (r-hGH), so monitoring adherence is an important component of effective management ...
Mynor Alvarez   +2 more
doaj   +1 more source

Effect of TAT-signaling fusion system along with co-expression of GroEL/ES chaperones on secretory expression of somatropin

open access: yesBioTechnologia, 2020
Human growth hormone (somatropin) is one of the most widely used recombinant proteins that stimulates growth, cell reproduction, and cell regulation in humans.
Mohammad Rabbani   +3 more
doaj   +1 more source

Clinicians’ Feedback on Patient/Carer Experience After Switching of Growth Hormone Treatment in Pediatric Patients During COVID-19

open access: yesPatient Preference and Adherence, 2021
Joanne Blair, 1 Kelly Warth, 2 Yashasvi Suvarna, 3 Marco Cappa 4 1Department of Endocrinology, Alder Hey Children’s NHS Foundation Trust, Liverpool, UK; 2Instar, London, UK; 3Global Medical Affairs, Novo Nordisk Global Business Services (GBS ...
Blair J, Warth K, Suvarna Y, Cappa M
doaj  

Structural and functional characterization of recombinant human growth hormone isolated from transgenic pig milk.

open access: yesPLoS ONE, 2020
This study aimed to establish and reproduce transgenic pigs expressing human growth hormone (hGH) in their milk. We also aimed to purify hGH from the milk, to characterize the purified protein, and to assess the potential of our model for mass production
So-Young Lee   +13 more
doaj   +1 more source

Long acting growth hormone (LAGH), an update

open access: yesFrontiers in Pediatrics, 2023
In 1957, Maurice Raben at Yale was able to isolate and purify growth hormone from cadaveric pituitary glands. Pituitary growth hormone was the only way to treat children with growth hormone (GH) deficiency, until 1985 when recombinant GH became available
Margaret Steiner Grillo   +2 more
doaj   +1 more source

Effect of Twine-arginine Translocation-signaling Fusion System and Chaperones Co-expression on Secretory Expression of Somatropin

open access: yesAdvanced Biomedical Research, 2018
Background: Twine-arginine translocation (TAT) system is one of the exporting systems in Escherichia coli which could transport fully/semi-correctly folded proteins outside the reductive cytoplasmic space.
Mohammad Reza Bagherinejad   +4 more
doaj   +1 more source

Multifactorial Nature of Childhood Stroke Presents a Major Challenge for Diagnosis and Management: A Population‐Based Study From Southern Finland

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim Childhood ischemic stroke is rare but causes substantial long‐term morbidity, and its heterogeneous aetiology complicates timely diagnosis and management. Methods We conducted a retrospective population‐based observational study using hospital data and chart review to describe diagnostics, treatment and outcomes of ischemic stroke in ...
Jussi V. Leinonen   +8 more
wiley   +1 more source

Long‐Acting Growth Hormone Versus Daily Growth Hormone for Growth Hormone Deficiency Patients: A Network Meta‐Analysis of Clinical Trials

open access: yesEndocrinology, Diabetes &Metabolism, Volume 9, Issue 5, September 2026.
This network meta‐analysis of 18 randomized controlled trials demonstrates that once‐weekly long‐acting growth hormone formulations offer comparable efficacy and safety to daily somatropin for paediatric growth hormone deficiency. While discontinuation rates remain similar, agent selection should consider specific local tolerability profiles, notably ...
Amir Abadi   +8 more
wiley   +1 more source

Geleophysic Dysplasia Associated With FBN1 Mutation: Clinical Course, Valvular Heart Disease, and Response to Recombinant Human Growth Hormone Therapy

open access: yesClinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Geleophysic dysplasia (GD) is a rare genetic condition caused by pathogenic variants in either the ADAMTSL2 or FBN1 gene. We present a patient that combined clinical features consistent with GD, including short stature, delayed bone age, progressive congenital heart disease, and a happy, round face.
Ray Thomas Katbe   +2 more
wiley   +1 more source

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