Results 51 to 60 of about 1,664 (165)

Geleophysic Dysplasia Associated With FBN1 Mutation: Clinical Course, Valvular Heart Disease, and Response to Recombinant Human Growth Hormone Therapy

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Geleophysic dysplasia (GD) is a rare genetic condition caused by pathogenic variants in either the ADAMTSL2 or FBN1 gene. We present a patient that combined clinical features consistent with GD, including short stature, delayed bone age, progressive congenital heart disease, and a happy, round face.
Ray Thomas Katbe, Laure Boutsen, Philippe A. Lysy   +2 more
wiley   +1 more source

Adherence to growth hormone therapy guidelines in a real-world French cohort of adult patients with growth hormone deficiency

, 2021
International audienceUsing real-world data from patients with growth hormone deficiency (GHD), we evaluated whether clinical practice in France adheres to international guidelines regarding somatropin dose adjustment, and assessed the long-term ...
Borson-Chazot, Françoise, Hacques, Evguenia, Chabre, Olivier, Klein, Marc, Brac de la Perriere, Aude, Salenave, Sylvie, Reznik, Yves, Kerlan, Véronique, Villette, Béatrice   +8 more
core   +1 more source

Growth Hormone‐Loaded 3D Printed Silk Fibroin‐Cellulose Dressings for Ischemic Wounds

Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.
3D‐printed wound dressings combining carboxymethyl cellulose, silk fibroin, and growth hormone accelerate healing in diabetic ulcers. These bioactive, customizable dressings enhance angiogenesis, cellular proliferation, and immune modulation. Proteomic analysis reveals activation of regenerative pathways and reduced fibrosis, highlighting their ...
Maria Pita‐Vilar, Diego Caicedo‐Valdés, Susana B. Bravo, Isabel Rodriguez‐Moldes, Salvador D. Aznar‐Cervantes, Angel Concheiro, Carmen Alvarez‐Lorenzo, Luis Diaz‐Gomez   +7 more
wiley   +1 more source

Epidemiology of acquired hypothalamic obesity following traumatic brain injury and nonspecific hypothalamic microinjury: A nationwide German claims data analysis

Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.
Abstract Acquired hypothalamic obesity (aHO) is characterized by rapid and persistent weight gain resulting from structural or functional damage to the hypothalamus, typically accompanied by neuroendocrine dysfunction. While aHO is well described in the context of hypothalamic or suprasellar tumors, particularly craniopharyngioma, little is known about
Julian Witte, Nicolas Touchot, Manuel Batram, Jana Diekmannshemke, Mathias Flume, Hermann L. Müller   +5 more
wiley   +1 more source

X‐Linked Hypophosphatemia Caused by a New Partial Insertion of LINE‐1 in the PHEX Gene

Human Mutation, Volume 2026, Issue 1, 2026.
X‐linked hypophosphatemia (XLH), primarily caused by mutations of the PHEX gene, is the most common cause of genetic rickets. Pediatric cases of XLH typically present with elevated levels of serum fibroblast growth factor 23 (FGF23), hypophosphatemia, rickets, and impaired growth.
Dongmei Li, Wan Peng, Lu Kang, Jia Geng, Yu Lu, Jing Lu, Chen Jian-Min   +6 more
wiley   +1 more source

Prospects and Trends in the Brazilian Market for Biologically Sourced Products

Journal of Technology Management & Innovation, 2012
The aim of this paper was to select the most interesting Brazilian biopharmaceuticals, with the best market opportunity for production. The biopharmaceuticals filgrastim, infliximab, somatropin, imiglucerase, betainterferon and factor VIII were selected ...
Luciana da Silva Madeira, Suzana Borschiver, Nei Pereira Jr   +2 more
doaj   +1 more source

Thoraco‐Omphalopagus Conjoined Twins Following IVF With Day 5 Embryo Transfer: A Rare Case Report and Multidisciplinary Management Approach

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Conjoined twinning is a rare and severe complication of monozygotic pregnancies. Assisted reproductive technologies (ART), including in vitro fertilization (IVF), may increase the risk of such anomalies. We report a case of thoraco‐omphalopagus conjoined twins following a day 5 embryo transfer after IVF with intracytoplasmic sperm injection ...
Patryk Piekos, Natalia Ravelo, Rodrigo Ruano, George Attia   +3 more
wiley   +1 more source

Host Cell Protein Clinical Safety Risk Assessment—An Updated Industry Review

Biotechnology and Bioengineering, Volume 122, Issue 11, Page 3229-3248, November 2025.
ABSTRACT Host cell proteins (HCP) are process‐related impurities that can co‐purify with therapeutic proteins. Some HCP impurities potentially can have an impact on patient safety (immunogenicity or toxicity), efficacy, and/or product quality. It is important to reduce the levels of HCP impurities with a well‐controlled manufacturing process and to ...
Lisette Coye, Marisa A. Jones, Georgeen Gaza‐Bulseco, Carmelata Chitikila, Severine Clavier, Delphine Fougeron, Christine Grimaldi, Karen Hurkmans, Richard Hutchinson, Brenda Kellogg, Xinrong Liu, Nisha Palackal, Mahima Tank, Pascal Valax, Thomas Waerner, Fengqiang Wang, Ying Zhang, Yiwei Zhao, Sapphire Sloan, Christina Zuch de Zafra   +19 more
wiley   +1 more source

In Vitro Functional Quality Characterization of NOTA-Modified Somatropins [PDF]

, 2017
Chemical modifications on protein biopharmaceuticals introduce extra variability in addition to their inherent complexity, hence require more comprehensive analytical and functional characterization during their discovery, development, and manufacturing.
Han Yao (3751858), Xiaolong Xu (833921), Alex Maes (3751855), Frederick Verbeke (704109), Bert Gevaert (443952), Mike Sathekge (3751852), Bart De Spiegeleer (443955), Sarah De Saeger (630973), Nathalie Bracke (443951), Evelien Wynendaele (443950), Christophe Van de Wiele (3751849)   +10 more
core   +2 more sources

Adalimumab as a Potential Therapeutic Option for Metastatic Crohn's Disease With Genital Lesions and Edema: A Case Report

Clinical Case Reports, Volume 13, Issue 11, November 2025.
ABSTRACT Metastatic Crohn's disease (MCD) is a rare and complex extraintestinal manifestation of Crohn's disease (CD) that often profoundly affects patients' quality of life. This report presents a meticulously detailed case of a 12‐year‐old Iranian girl with persistent labial swelling and genital lesions, later diagnosed as MCD.
Hoda Haghshenas, Behnaz Darban, Mohammad Aref Bagherzadeh, Mehdi Karimi, Maryam Ataollahi   +4 more
wiley   +1 more source