Results 61 to 70 of about 1,664 (165)

Characterisation of modified pharmaceutical proteins: the somatropin case [PDF]

, 2010
Somatropin, a recombinant protein containing 191 amino acids, is derived from the endogenous human growth hormone, somatotropin [1]. This protein is clinically used in children and adults with inadequate endogenous growth hormone to stimulate a normal ...
De Spiegeleer, Bart, Wiskerke, Daphne, Wynendaele, Evelien   +2 more
core  

Escherichia coli in the production of biopharmaceuticals

Biotechnology and Applied Biochemistry, Volume 72, Issue 2, Page 528-541, April 2025.
Abstract Escherichia coli has shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, in E. coli and its use in treating diabetes. After insulin, many biopharmaceuticals produced from E. coli have been approved by the
İbrahim İncir, Özlem Kaplan
wiley   +1 more source

Somatropin therapy in adults with Prader-Willi syndrome

, 2004
Prader-Willi syndrome is a complex genetic disorder with a characteristic cognitive, behavioral, and endocrinologic phenotype. Obesity, partial growth hormone (GH) secretion, and hypogonadism are common. Results of several somatropin (GH therapy) studies
Thorén, M,, Höybye, C,
core   +1 more source

Pharmacokinetics‐Based Design of Subcutaneous Controlled Release Systems for Biologics

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 668-680, April 2025.
ABSTRACT Protein therapeutics have emerged as an exceedingly promising treatment modality in recent times but are predominantly given as intravenous administration. Transitioning to subcutaneous (SC) administration of these therapies could significantly enhance patient convenience by enabling at‐home administration, thereby potentially reducing the ...
Abigail K. Grosskopf, Antonio A. Ginart, Phillip Spinosa, Vittal Shivva   +3 more
wiley   +1 more source

LC-MS characterization and cell-binding properties of chelate modified somatropin [PDF]

, 2010
Somatropin, a recombinant protein containing 191 amino acids, is derived from the endogenous human growth hormone, somatotropin. This protein is clinically used in children and adults with inadequate endogenous growth hormone to stimulate a normal bone ...
De Spiegeleer, Bart, Mertens, Koen, Wynendaele, Evelien, Pauwels, Ewald, Van De Wiele, Christophe   +4 more
core  

Analytical characterisation of NOTA-modified somatropins [PDF]

, 2014
Chemical modification of biomolecules like the introduction of metal-chelators into proteins can lead to heterogeneous product formation. The nature and extend of the modification is important in interpreting the biological properties of the ...
Somsen, Govert W, Van de Wiele, C., Evelien Wynendaele, Ewald Pauwels, Wynendale, E., Wynendaele, Evelien, De Spiegeleer, Bart, Pauwels, E., Haselberg, R.; id_orcid, Haselberg, Rob, Christoph Van de Wiele, De Speigeleer, B., Matthias D’Hondt, Somsen, Govert W., Nathalie Bracke, D’Hondt, Matthias, Rob Haselberg, Bracke, Nathalie, Govert W. Somsen, D'Hondt, M., D'Hondt, Matthias, Bracke, N., Pauwels, Ewald, Bart De Spiegeleer, Van De Wiele, Christophe, Somsen, G.W.   +25 more
core   +1 more source

Gene doping in horse racing and equine sports: Current landscape and future perspectives

Equine Veterinary Journal, Volume 57, Issue 2, Page 312-324, March 2025.
Abstract Gene doping, the use of gene therapy or genetic manipulation to enhance athletic performance, has emerged as a potential threat to the integrity and welfare of equine sports, such as horse racing and equestrian sports. This review aims to provide an overview of gene doping in horses, including the underlying technologies, potential ...
Maria Puchalska, Olga Witkowska‐Piłaszewicz   +1 more
wiley   +1 more source

Cost-Effectiveness of Growth Hormone (Somatropin) for the Treatment of Children with Short Stature

پیاورد سلامت, 2018
Background and Aim: One of the common problems of children all over the world is short stature. Due to the high costs of treatment, the present research studied the cost-effectiveness of growth hormone (Somatropin) for the treatment of children with ...
Mohammad Tasavon Gholamhoseini, Mohsen Barouni, Nooshin Afsharzadeh, Mohammad Jafar iSirizi   +3 more
doaj  

A Medical Rarity: Isolated Toxoplasma gondii Abscess in the Pituitary Gland of an Immunocompetent Patient

Case Reports in Infectious Diseases, Volume 2025, Issue 1, 2025.
The occurrence of sellar toxoplasmosis in the pituitary gland is exceedingly rare, and only a few reports have been published in the literature, primarily impacting immunocompromised patients. We report an intriguing case of a 54‐year‐old man with an initial asymptomatic panhypopituitarism diagnosed under investigation for urolithiasis.
Erlend Moen Taule, Hrvoje Miletic, Rupavathana Mahesparan, Rajib Chowdhury   +3 more
wiley   +1 more source

Analysis of Somatropin by Double-Injection Capillary-Zone Electrophoresis in Polybrene/Chondroitin Sulfate A Double-Coated Capillaries

, 2016
Purity determination of somatropin as a recombinant protein is important to ensure its safety and quality. This is carried out by capillary zone electrophoresis in double-injection mode using polybrene/chondroitin sulfate A double-coated capillaries ...
Amini, Ahmad,, Ahmad Amini
core   +1 more source