Results 71 to 80 of about 1,664 (165)

Comparative efficacy of mono- and combined therapy for idiopathic short stature with delayed puberty

Mìžnarodnij Endokrinologìčnij Žurnal, 2018
Background. Growth hormone therapy for idio­pathic short stature (ISS) is a subject of debate, because of the heterogeneous endocrine profile in these children.
G.N. Rakhimova, K.N. Gilyazetdinov
doaj   +1 more source

Somatropin treatment of spinal muscular atrophy: A placebo-controlled, double-blind crossover pilot study

, 2014
In preclinical studies growth hormone and its primary mediator IGF-1 have shown potential to increase muscle mass and strength. A single patient with spinal muscular atrophy reported benefit after compassionate use of growth hormone.
Schottmann, G., Schara, Ulrike, Mueller-Felber, Wolfgang, Hobbiebrunken, Elke, Schorling, D., Kirschner, J., Thiele, Simone, Hauschke, Dieter, Rensing-Zimmermann, C., Wein, U., Stettner, Georg M., Grieben, Ulrike, Rensing, Cornelia, Müller-Felber, Wolfgang, Wilichowski, Ekkehard, Schorling, David, Schottmann, Gudrun, Konrad, K., Hauschke, D., Wilichowski, E., Konrad, Kerstin, Korinthenberg, Rudolf, Kirschner, Janbernd   +22 more
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Twin arginine translocation system in secretory expression of recombinant human growth hormone

Research in Pharmaceutical Sciences, 2016
Recombinant protein production in E. coli has several advantages over other expression systems. Misfolding, inclusion body formation, and lack of eukaryotic post translational modification are the most disadvantages of this system. Exporting of correctly
Mohammad Reza Bagherinejad, Hamid Mir-Mohammad Sadeghi, Daryoush Abedi, C Perry Chou, Fatemeh Moazen, Mohammad Rabbani   +5 more
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An investigation of the anabolic actions of biosynthetic human growth hormone after injury by burning [PDF]

, 1990
Previous clinical trials in normal subjects and post-operative patients have shown that biosynthetic growth hormone preparations increase nitrogen retention. It has been suggested that their administration to injured patients may be beneficial.
Belcher, H. J. C. R.
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Long-term safety and efficacy of Omnitrope® in adults with growth hormone deficiency: Italian interim analysis of the PATRO Adults study [PDF]

, 2017
To report the long-term effectiveness and safety of the recombinant human growth hormone Omnitrope(®), a somatropin biosimilar to Genotropin(®), in Italian patients with growth hormone deficiency (GHD) enrolled in the PATRO Adults ...
Profka, E., COLAO, ANNAMARIA, Beck-Peccoz, P., C. Di Somma, Ambrosio, M. R., Arnaldi, G., DI SOMMA, CAROLINA, Gasco, V, C. Pagano, G. Arnaldi, Pietropoli, A, Arnaldi, G, Pietropoli, A., E. Zecchi, Beck-Peccoz, P, Ferone, D, DI SOMMA, CAMILLA, V. Gasco, Colao, A, Gasco, V., D. Ferone, E. Profka, M. R. Ambrosio, Zecchi, E., Di Somma, C, PAGANO, CLAUDIO, Colao, A., Puxeddu, E., E. Puxeddu, P. Beck-Peccoz, Zecchi, E, A. Colao, ARNALDI, GIULIA, Ambrosio, M R, Puxeddu, E, Ferone, D., Pagano, C., FERONE, DIEGO, Profka, E, Di Somma, C., A. Pietropoli, Ambrosio, M. R, Pagano, C, Beck Peccoz, P.   +43 more
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Cost-consequence analysis for human recombinant growth hormone (r-hGH) treatment administered via different devices in children with growth hormone deficiency in Italy

ClinicoEconomics and Outcomes Research, 2019
Jason Foo,1 Mohamad Maghnie,2 Annamaria Colao,3 Ioanna Vlachaki,4 Giorgio Colombo5,61Global Health Economics, Mapi Group (An ICON plc Company), Houten, The Netherlands; 2Department of Pediatrics, IRCCS Istituto Giannina Gaslini Institute, University of ...
Foo J, Maghnie M, Colao A, Vlachaki I, Colombo G   +4 more
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Results from an international multicenter trial evaluating the ease-of-use of and preference for a newly developed disposable injection pen for the treatment of growth hormone deficiency in treatment-naïve children and adults

Medical Devices: Evidence and Research, 2014
Andreas M Pleil,1 Feyza Darendeliler,2 Helmuth G Dörr,3 Katherine Hutchinson,4 Hartmut A Wollmann5 1Pfizer Inc., San Diego, CA, USA; 2Istanbul Faculty of Medicine, Pediatric Endocrinology Unit, Capa, Istanbul, Turkey; 3Department of Pediatrics ...
Pleil AM, Darendeliler F, Dörr HG, Hutchinson K, Wollmann HA   +4 more
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Improving selectivity and sensitivity of protein quantitation by LC-HR-MS/MS:Determination of somatropin in rat plasma [PDF]

, 2018
AIM: Protein quantitation by digestion of a biological sample followed by LC-MS analysis of a signature peptide can be a challenge because of the high complexity of the digested matrix.
Bischoff, Rainer, van de Merbel, Nico C, Bischoff, Rainer; id_orcid, Meints, Marcel, Bults, Peter; id_orcid, Bults, Peter, Sonesson, Anders, Knutsson, Magnus   +7 more
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Safety and Effectiveness of a Biosimilar Recombinant Growth Hormone in Adults with Growth Hormone Deficiency: Analysis of Final Data from PATRO Adults, an International Post-Marketing Surveillance Study

Drug Design, Development and Therapy
Paolo Beck-Peccoz,1 Charlotte Höybye,2 Suat Simsek,3 Günter Stalla,4 Robert  D Murray,5 Altaher Esmael,6 Dragan Urosevic,7 Anca Boldea,6 Markus Zabransky6 1Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Cà Granda Ospedale Maggiore ...
Beck-Peccoz P, Höybye C, Simsek S, Stalla G, Murray RD, Esmael A, Urosevic D, Boldea A, Zabransky M   +8 more
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EVALUATION OF EFFECT OF PROLONGED ACTION SOMATOSTATIN ANALOGUE – OCREOTIDE-DEPO – ON THE FOLLOWING HORMONAL AND CYTOTOXIC THERAPY IN PATIENTS WITH METASTATIC CASTRATE-RESISTANT PROSTATE CANCER (М-CRPC)

Медицинский совет, 2017
Therapy of CRPC is one of the most difficult problems in oncourology. Until now the optimal consequence of use of drugs in CRPC is not determined.Study objective: evaluation of effectiveness  of sequential  therapeutic schemes  in progression of m-CRPC ...
S. V. Mishugin, A. A. Gritskevich, A. A. Mordovin, I. G. Rusakov   +3 more
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