Results 41 to 50 of about 1,206 (142)
JCRPEObjective: To report real-world 6- and 12-month outcomes in children with growth hormone deficiency (GHD) treated with somatrogon or somatropin, including those who transitioned from somatropin to somatrogon.
Kübra Şen Küçük +5 more
doaj +1 more source
Growth Hormone‐Loaded 3D Printed Silk Fibroin‐Cellulose Dressings for Ischemic Wounds
Advanced Healthcare Materials, Volume 15, Issue 5, 2 February 2026.3D‐printed wound dressings combining carboxymethyl cellulose, silk fibroin, and growth hormone accelerate healing in diabetic ulcers. These bioactive, customizable dressings enhance angiogenesis, cellular proliferation, and immune modulation. Proteomic analysis reveals activation of regenerative pathways and reduced fibrosis, highlighting their ...
Maria Pita‐Vilar +7 more
wiley +1 more source
Frontiers in Endocrinology, 2021 ObjectiveThe International Cooperative Growth Study, NutropinAq® European Registry (iNCGS) (NCT00455728) monitored long-term safety and effectiveness of recombinant human growth hormone (rhGH; NutropinAq® [somatropin]) in paediatric growth disorders ...
Regis Coutant +6 more
doaj +1 more source
Prospects and Trends in the Brazilian Market for Biologically Sourced Products
Journal of Technology Management & Innovation, 2012 The aim of this paper was to select the most interesting Brazilian biopharmaceuticals, with the best market opportunity for production. The biopharmaceuticals filgrastim, infliximab, somatropin, imiglucerase, betainterferon and factor VIII were selected ...
Luciana da Silva Madeira +2 more
doaj +1 more source
Clinical Case Reports, Volume 13, Issue 12, December 2025.ABSTRACT Conjoined twinning is a rare and severe complication of monozygotic pregnancies. Assisted reproductive technologies (ART), including in vitro fertilization (IVF), may increase the risk of such anomalies. We report a case of thoraco‐omphalopagus conjoined twins following a day 5 embryo transfer after IVF with intracytoplasmic sperm injection ...
Patryk Piekos +3 more
wiley +1 more source
Host Cell Protein Clinical Safety Risk Assessment—An Updated Industry Review
Biotechnology and Bioengineering, Volume 122, Issue 11, Page 3229-3248, November 2025.ABSTRACT Host cell proteins (HCP) are process‐related impurities that can co‐purify with therapeutic proteins. Some HCP impurities potentially can have an impact on patient safety (immunogenicity or toxicity), efficacy, and/or product quality. It is important to reduce the levels of HCP impurities with a well‐controlled manufacturing process and to ...
Lisette Coye +19 more
wiley +1 more source
Clinical Case Reports, Volume 13, Issue 11, November 2025.ABSTRACT Metastatic Crohn's disease (MCD) is a rare and complex extraintestinal manifestation of Crohn's disease (CD) that often profoundly affects patients' quality of life. This report presents a meticulously detailed case of a 12‐year‐old Iranian girl with persistent labial swelling and genital lesions, later diagnosed as MCD.
Hoda Haghshenas +4 more
wiley +1 more source
Escherichia coli in the production of biopharmaceuticals
Biotechnology and Applied Biochemistry, Volume 72, Issue 2, Page 528-541, April 2025.Abstract Escherichia coli has shouldered a massive workload with the discovery of recombinant DNA technology. A new era began in the biopharmaceutical industry with the production of insulin, the first recombinant protein, in E. coli and its use in treating diabetes. After insulin, many biopharmaceuticals produced from E. coli have been approved by the
İbrahim İncir, Özlem Kaplan
wiley +1 more source
Pharmacokinetics‐Based Design of Subcutaneous Controlled Release Systems for Biologics
CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 668-680, April 2025.ABSTRACT Protein therapeutics have emerged as an exceedingly promising treatment modality in recent times but are predominantly given as intravenous administration. Transitioning to subcutaneous (SC) administration of these therapies could significantly enhance patient convenience by enabling at‐home administration, thereby potentially reducing the ...
Abigail K. Grosskopf +3 more
wiley +1 more source
Gene doping in horse racing and equine sports: Current landscape and future perspectives
Equine Veterinary Journal, Volume 57, Issue 2, Page 312-324, March 2025.Abstract Gene doping, the use of gene therapy or genetic manipulation to enhance athletic performance, has emerged as a potential threat to the integrity and welfare of equine sports, such as horse racing and equestrian sports. This review aims to provide an overview of gene doping in horses, including the underlying technologies, potential ...
Maria Puchalska +1 more
wiley +1 more source