Results 41 to 50 of about 1,664 (165)

Langzeitdaten zur Sicherheit Somatropin-haltiger Arzneimittel – die SAGhE-Studie

, 2012
Somatropin wird als wachstumsförderndes Hormon zur Behandlung von mit Wachstumshormonmangel und Kleinwuchs einhergehenden Erkrankungen angewendet. Die europaweit durchgeführte SAGhE-Studie (Safety and Appropriateness of Growth hormone treatments in ...
Hillen, H., Weise, M., Krappweis, J., Chatterjee, S., Wittstock, M., Strassmann,V., Strassmann, V.   +6 more
core   +1 more source

Multifactorial Nature of Childhood Stroke Presents a Major Challenge for Diagnosis and Management: A Population‐Based Study From Southern Finland

Acta Paediatrica, Volume 115, Issue 10, Page 2332-2340, October 2026.
ABSTRACT Aim Childhood ischemic stroke is rare but causes substantial long‐term morbidity, and its heterogeneous aetiology complicates timely diagnosis and management. Methods We conducted a retrospective population‐based observational study using hospital data and chart review to describe diagnostics, treatment and outcomes of ischemic stroke in ...
Jussi V. Leinonen, Samu Kurki, Siina Pamilo, Juho Immonen, Juha Knuuttila, Matti Hero, Mia Westerholm‐Ormio, Pirjo Isohanni, Miika Koskinen   +8 more
wiley   +1 more source

HPLC-MS characterisation of chelate modified somatropin [PDF]

, 2010
Somatropin is a recombinant human growth hormone, consisting of 191 amino acids. This protein is clinically used in children and adults with inadequate endogenous growth hormone to stimulate a normal bone and muscle growth.
De Spiegeleer, Bart, Van Dorpe, Sylvia, Wynendaele, Evelien, Pauwels, Ewald, Vergote, Valentijn, Van De Wiele, Christophe   +5 more
core  

Structural and functional characterization of recombinant human growth hormone isolated from transgenic pig milk.

PLoS ONE, 2020
This study aimed to establish and reproduce transgenic pigs expressing human growth hormone (hGH) in their milk. We also aimed to purify hGH from the milk, to characterize the purified protein, and to assess the potential of our model for mass production
So-Young Lee, Joo-Hee Han, Eun-Kyeong Lee, Young Kyu Kim, Seo-Ah Hwang, Sung-Hyun Lee, Maria Kim, Gye Yoon Cho, Jae-Ha Hwang, Su-Jin Kim, Jae-Gyu Yoo, Seong-Keun Cho, Kyung-Ju Lee, Weon-Ki Cho   +13 more
doaj   +1 more source

Self-reported vs electronically-recorded adherence to GH therapy

Revista Colombiana de Endocrinología, Diabetes y Metabolismo, 2022
Introduction: Adherence to the prescribed injection schedule is critical for the success of treatment of growth disorders with recombinant human growth hormone (r-hGH), so monitoring adherence is an important component of effective management ...
Mynor Alvarez, Pablo Guzmán , Selina Graham   +2 more
doaj   +1 more source

IMPROVE 2025: The 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence

Clinical Obesity, Volume 16, Issue 5, October 2026.
ABSTRACT An international cohort of 161 clinicians and researchers from 19 countries attended the 3rd International Meeting on Pathway‐Related Obesity: Vision & Evidence (IMPROVE) in Prague, Czech Republic, on 2–4 July 2025. The aims of the meeting were to advance understanding of hyperphagia and obesity caused by defects in the melanocortin‐4 receptor
Jesús Argente, Erica L. T. van den Akker, Metin Cetiner, Karine Clément, Elizabeth Forsythe, Alastair Garfield, Peter Kühnen, Gabriel Ángel Martos‐Moreno, David Meeker, Hermann L. Müller, Hanneke M. van Santen, Julia von Schnurbein, Bérénice Segrestin, Tomohiro Tanaka, Manuel Tena‐Sempere, Martin Wabitsch, Stefanie Zorn, I. Sadaf Farooqi   +17 more
wiley   +1 more source

Clinicians’ Feedback on Patient/Carer Experience After Switching of Growth Hormone Treatment in Pediatric Patients During COVID-19

Patient Preference and Adherence, 2021
Joanne Blair, 1 Kelly Warth, 2 Yashasvi Suvarna, 3 Marco Cappa 4 1Department of Endocrinology, Alder Hey Children’s NHS Foundation Trust, Liverpool, UK; 2Instar, London, UK; 3Global Medical Affairs, Novo Nordisk Global Business Services (GBS ...
Blair J, Warth K, Suvarna Y, Cappa M
doaj  

Long acting growth hormone (LAGH), an update

Frontiers in Pediatrics, 2023
In 1957, Maurice Raben at Yale was able to isolate and purify growth hormone from cadaveric pituitary glands. Pituitary growth hormone was the only way to treat children with growth hormone (GH) deficiency, until 1985 when recombinant GH became available
Margaret Steiner Grillo, Jacklyn Frank, Paul Saenger   +2 more
doaj   +1 more source

Central Precocious Puberty in Williams Syndrome: Two Cases Illustrating Diagnostic Challenges and Individualized Management

Clinical Case Reports, Volume 14, Issue 8, August 2026.
ABSTRACT Central precocious puberty (CPP) is an increasingly recognized endocrine comorbidity in girls with Williams syndrome (WS), but its diagnosis and management may be complicated by the short stature and atypical growth pattern associated with WS. We report two girls with genetically confirmed WS and CPP who showed different clinical presentations
Kangxiang Liu, Sha Zhao, Xinghan Wu, Xiaomei Jiang, Xiaoming Li   +4 more
wiley   +1 more source

Association of Growth Hormone Adherence and Growth Outcomes in Paediatric Patients: Results From a Clinical Registry

Clinical Endocrinology, Volume 104, Issue 6, Page 603-611, June 2026.
ABSTRACT Objective Daily growth hormone (GH) therapy for growth disorders requires long‐term adherence. The aim of this study was to investigate the association of adherence with 2‐year growth outcomes in paediatric patients receiving daily GH therapy in a clinical registry. Design Retrospective cohort study. Patients Patients with growth disorder were
Tilman Robert Rohrer, Klaus Hartmann, Peter Herbert Kann, Tobias Vogelmann, Dorna Hogeabri, Tino Schubert   +5 more
wiley   +1 more source