Nature Communications, 2017 Endoderm enhancer MACS1 of Sonic Hedgehog is conserved in animals with lungs. Here, the authors show that mouse without MACS1 has defective laryngeal development, and use phylogenetic analyses to show association of evolutionary lung-gas bladder ...
Tomoko Sagai +9 more
doaj +1 more source
Induction of sonic hedgehog and patched by retinoic acid in the developing rat lung in vitro. • 292 [PDF]
, 1997 Margaret Rush, Douglas Perkins
openalex +1 more source
Clinical Genetics, EarlyView.Trio exome sequencing allowed the identification of two novel compound heterozygous variants in PIK3C2A, defining the fifth family presenting a PIK3C2A‐related syndrome characterized by pulverulent cataracts and deafness. Functional testing revealed impaired PI metabolism and primary dysfunction phenotype.
Adella Karam +9 more
wiley +1 more source
Genipin suppresses colorectal cancer cells by inhibiting the Sonic Hedgehog pathway
OncoTarget, 2017 Genipin, a major component of Gardenia jasminoides Ellis fruit, has been shown to inhibit the growth of gastric, prostate, and breast cancers. However, the anti-proliferative activity of genipin in colorectal cancer (CRC) has not been characterized ...
Bo Ram Kim +10 more
semanticscholar +1 more source
Sonic hedgehog directs specialised mesoderm differentiation in the intestine and pancreas [PDF]
, 1997 Åsa Apelqvist +2 more
openalex +1 more source
Sonic hedgehog signaling in the lung. From development to disease.
American Journal of Respiratory Cell and Molecular Biology, 2015 Over the past two decades, the secreted protein sonic hedgehog (SHH) has emerged as a critical morphogen during embryonic lung development, regulating the interaction between epithelial and mesenchymal cell populations in the airway and alveolar ...
M. Kugler +3 more
semanticscholar +1 more source
Sonic hedgehog regulates the position of the trigeminal ganglia
Developmental Biology, 2003 The trigeminal ganglia differentiate in part from specialized ectodermal structures in the embryonic head termed the trigeminal placodes. However, the signals which govern the migration of trigeminal precursors and the final morphology of the ganglia are poorly defined.
FEDTSOVA N. +2 more
openaire +4 more sources
The Mutational Spectrum of the Sonic Hedgehog Gene in Holoprosencephaly: SHH Mutations Cause a Significant Proportion of Autosomal Dominant Holoprosencephaly [PDF]
, 1999 Luisa Nanni +16 more
openalex +1 more source
Implication of GPRASP2 in the Proliferation and Hair Cell‐Forming of Cochlear Supporting Cells
Cell Proliferation, EarlyView.Schematic diagram of GPRASP2‐mediated SCs proliferation and HCs formation. GPRASP2 deficiency results in increased lysosomal degradation of SMO. GPRASP2‐mediated SMO/GLI1 signalling promotes SC proliferation, which contributes to HC formation. GPRASP2‐mediated SMO/β‐catenin signalling is implicated in HCs fate specification and differentiation ...
Jing Cai +9 more
wiley +1 more source
Engineering Intervertebral Disc Regeneration: Biomaterials, Cell Sources and Animal Models
Cell Proliferation, EarlyView.This review highlights the current tissue engineering approaches utilising biomaterials, animal models and cell sources for intervertebral disc regeneration and discusses future opportunities. ABSTRACT Intervertebral disc (IVD) degeneration is an age‐related problem triggering chronic spinal issues, such as low back pain and IVD herniation.
Sidong Yang +8 more
wiley +1 more source