Exosomal Sonic Hedgehog derived from cancer‐associated fibroblasts promotes proliferation and migration of esophageal squamous cell carcinoma [PDF]
, 2020 Guiping Zhao +6 more
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Data from A Druggable UHRF1/DNMT1/GLI Complex Regulates Sonic Hedgehog–Dependent Tumor Growth
, 2023 Fan Yang +14 more
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Orthodontics &Craniofacial Research, Volume 29, Issue 1, Page 1-11, February 2026.ABSTRACT Crouzon and Apert syndromes are rare syndromic craniosynostoses frequently associated with craniofacial and dental anomalies, including tooth agenesis. Although individual studies have reported tooth agenesis prevalence data in specific populations, no attempts have been made to systematically synthesise these data.
M. Cecilia Becerril Santos +3 more
wiley +1 more source
Formin isoforms are differentially expressed in the mouse embryo and are required for normal expression of fgf-4 and shh in the limb bud [PDF]
, 1995 Mice homozygous for the recessive limb deformity (ld) mutation display both limb and renal defects. The limb defects, oligodactyly and syndactyly, have been traced to improper differentiation of the apical ectodermal ridge (AER) and shortening of the ...
Chan, David C. +2 more
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HOXB4 Promotes Bladder Cancer Progression in Part Through Transcriptional Activation of Smoothened
The FASEB Journal, Volume 40, Issue 1, 15 January 2026.HOXB4 is overexpressed in bladder cancer and associated with poor prognosis. By transcriptionally activating Smoothened (SMO), HOXB4 amplifies SMO–GLI signaling to promote tumor growth and metastatic behavior. This graphical abstract highlights the HOXB4–SMO axis as a key driver of bladder cancer progression and a potential target for future ...
Zhaoheng Jin +6 more
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Sufu and Gli3 repressor mediate the temporal basal-to-apical progression of hair cell differentiation in mammalian cochleae [PDF]
, 2014 Poster presentation - Theme 3: Development & stem cellsThe Sonic Hedgehog pathway plays important roles in mammalian inner ear development. Mutations of Shh, Smo and Gli3 lead to severe defects in mouse inner ear morphogenesis.
Hui, CC +4 more
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The Journal of Pathology: Clinical Research, Volume 12, Issue 1, January 2026.Abstract Uterine tumor resembling ovarian sex cord tumor (UTROSCT) constitutes an exceptionally rare histological subset of uterine mesenchymal neoplasms. While most cases have benign clinical behavior, a subset of UTROSCTs exhibits clinically aggressive behavior characterized by recurrence and metastasis.
Jing Yang +6 more
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Coordinate actions of BMPs, Wnts, Shh and noggin mediate patterning of the dorsal somite [PDF]
, 1997 Shortly after their formation, somites of vertebrate embryos differentiate along the dorsoventral axis into sclerotome, myotome and dermomyotome.
Bronner-Fraser, Marianne +2 more
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BioEssays, Volume 48, Issue 1, January 2026.In distal limb wounds on the horse, the proliferative phase of repair often produces excessive granulation tissue that delays healing by impeding keratinocyte migration from wound margins. This essay examines the basis for the hypothesis that ephrin–Eph signaling pathways that stimulate keratinocyte migration provide novel targets for re‐establishing ...
Rodolfo D. Vicetti Miguel +3 more
wiley +1 more source
Sonic Hedgehog as a Regulator of Endometrial Mesenchymal Stem/Stromal Cell Activity
, 2020 James A. Deane
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