Results 171 to 180 of about 66,215 (305)

The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma

Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.
ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha, Danielle Twilley, Mona Dawood, Thomas Efferth, Namrita Lall   +4 more
wiley   +1 more source

A Sonic Hedgehog-Gli-Bmi1 signaling pathway plays a critical role in p27 deficiency induced bone anabolism [PDF]

, 2022
Jun Wu, Rong Wang, Xuechun Kan, Jinghan Zhang, Wen Sun, David Goltzman, Dengshun Miao   +6 more
openalex   +1 more source

Venous Endothelial Cells Promote Osteoblast Differentiation More Effectively Than Arterial Cells via TGF‐β/BMP9 and Notch Pathway‐Related Gene Expression

Cell Biochemistry and Function, Volume 44, Issue 1, January 2026.
ABSTRACT The coupling between angiogenesis and osteogenesis is a key determinant of skeletal homeostasis, yet the influence of endothelial cell origin on osteoblast differentiation remains underexplored. Here, we investigated how venous (HUVECs) and arterial (HCAECs) endothelial cells differentially modulate the osteogenic phenotype of human ...
Célio J. C. Fernandes, Rodrigo A. Foganholi da Silva, Marcel R. Ferreira, Willian F. Zambuzzi   +3 more
wiley   +1 more source

Sonic hedgehog signalling proteins are frequently expressed in retinoblastoma and are associated with aggressive clinicopathological features

, 2014
Ji‐Young Choe, Ji Yun Yun, Yoon Kyung Jeon, Se Hoon Kim, Ho-Kyung Choung, Sohee Oh, Mira Park, Ji Eun Kim   +7 more
openalex   +2 more sources

Developmental Impact of Maternal Immune Activation on the Fetal Immune System and Lung

European Journal of Immunology, Volume 56, Issue 1, January 2026.
Maternal immune activation triggers elevated cytokines (IL‐6 and IL‐17A), disrupting fetal immune system development. This not only alters hematopoietic stem cell balance but also leads to ILC2 hyperactivation in the lung, which could potentially affect susceptibility to allergic diseases in the offspring.
Walaa Jradi, Kira Duhm, Clarissa Prazeres da Costa   +2 more
wiley   +1 more source

Analiza gena i proteina signalnih puteva Wnt i Sonic Hedgehog u primarnoj i sekundarnoj mijelofibrozi [Analysis of genes and proteins of WNT and Sonic Hedgehog signaling pathways in primary and secondary myelofibrosis] [PDF]

, 2017
Marko Lucijanić
openalex  

Loss of the Heparan Sulfate Proteoglycan Glypican5 Facilitates Long-Range Sonic Hedgehog Signaling [PDF]

, 2019
Wei Guo, Henk Roelink
openalex   +1 more source

Sonic hedgehog et Boc [PDF]

médecine/sciences, 2008
Pierre Fabre, Steves Morin, Frédéric Charron   +2 more
openaire   +1 more source

Natural Products Targeting Notch Signaling in Cancer: Mechanistic Insights and Food‐Based Chemoprevention Potential

Food Frontiers, Volume 7, Issue 1, January 2026.
The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima, Parteek Prasher, Mousmee Sharma, Dietrich Büsselberg, Gabriela Figueroa‐González, Octavio Daniel Reyes‐Hernández, Edgar Yebrán Villegas‐Vázquez, Hernán Cortés, Gerardo Leyva‐Gómez, Jesús Herrera‐Bravo, Solomon Habtemariam, Javad Sharifi‐Rad, Monica Butnariu, Cristian Berar, Angela Caunii, William C. Cho   +15 more
wiley   +1 more source

0748 Synergy of TP53 and non-canonical sonic hedgehog pathway in the development of complex basal cell carcinoma [PDF]

Sophia Gandarillas, Darius Mehregan, Adam C. Berger, Bahar Dasgeb   +3 more
openalex   +1 more source