Results 21 to 30 of about 581 (108)

The safety and efficacy of sonidegib for the treatment of locally advanced basal cell carcinoma [PDF]

, 2016
Introduction: Basal cell carcinomas (BCCs) are the commonest malignancy in the Western world. Locally advanced BCCs (laBCCs) represent tumours that have developed in difficult-to-treat facial sites, aggressively recurrent tumours, large neglected tumours
Lear, John T., Ali, Faisal R., Collier, Nicholas J.   +2 more
core   +1 more source

Expression of Glioma-associated oncogene homolog 1 as biomarker with sonidegib in advanced basal cell carcinoma [PDF]

, 2020
The pivotal BOLT (Basal cell carcinoma Outcomes with LDE225 [sonidegib] Treatment) study established the durable efficacy and manageable toxicity of sonidegib 200 mg once daily (QD) through 42 months in patients with advanced basal cell carcinoma (BCC ...
Liu, Li, Dummer, Reinhard; https://orcid.org/, Gutzmer, Ralf, Lear, John, Squittieri, Nicholas, Liu L, Dummer R, Squittieri N, Lear J, Gutzmer R   +9 more
core   +1 more source

Efficacy and safety of sonidegib for the management of basal cell carcinoma: a drug safety evaluation

, 2023
Introduction: Surgery is the standard management for most of basal cell carcinomas (BBCs). In some cases, also radiotherapy may be a valuable weapon as well as ablative and topical treatments.
Francesco Lacarrubba, Luca Potestio, Lacarrubba, Francesco, Luigi Fornaro, Guerrasio, Gianluca, Alessia Villani, Angelo Ruggiero, Gianluca Guerrasio, Micali, Giuseppe, Villani, Alessia, Fornaro, Luigi, Ruggiero, Angelo, Giuseppe Micali, Potestio, Luca, Genco, Lucia, Lucia Genco, Scalvenzi, Massimiliano, Massimiliano Scalvenzi, Villani A., Genco L., Potestio L., Micali G., Lacarrubba F., Scalvenzi M., Ruggiero A., Guerrasio G., Fornaro L.   +26 more
core   +1 more source

Phase I and phase II sonidegib and vismodegib clinical trials for the treatment of paediatric and adult MB patients: a systemic review and meta-analysis

Acta Neuropathologica Communications, 2019
Background Medulloblastoma (MB) is the most common malignant brain tumour in children but also rarely occur in adults. Sonic Hedgehog (SHH) driven MB is associated with aberrant activation of the SHH signalling pathway.
Yuchen Li, Qingkun Song, Bryan W. Day
doaj   +1 more source

Sonidegib for management of periocular basal cell carcinoma: case report and literature review

Academia Oncology
Treatment of periocular basal cell carcinoma (BCC) is difficult due to proximity to critical structures, including the eye and intracranial areas.
Elizabeth Fan, Kali Morrissette, Sakshi Chopra, Stephanie Hendren, Michelle Pavlis   +4 more
doaj   +1 more source

Clinical Clearance Following Improvement of Histologic Subtype of Basal Cell Carcinoma with Sonidegib

Acta Dermato-Venereologica, 2022
is missing (Short communication)
Liang Joo Leow, Vicki Howard
doaj   +1 more source

Targeted Delivery of 5-Fluorouracil and Sonidegib via Surface-Modified ZIF-8 MOFs for Effective Basal Cell Carcinoma Therapy

Pharmaceutics, 2023
The therapeutic effectiveness of the most widely used anticancer drug 5-fluorouracil (5-FU) is constrained by its high metabolism, short half-life, and rapid drug resistance after chemotherapy.
Bharath Singh Padya, Gasper Fernandes, Sumukha Hegde, Sanjay Kulkarni, Abhijeet Pandey, Praful Balavant Deshpande, Sheikh F. Ahmad, Dinesh Upadhya, Srinivas Mutalik   +8 more
doaj   +1 more source

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

The Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo, Haoyan Han, Michael O'Dwyer, Eileen Reidy, Aideen E. Ryan   +4 more
wiley   +1 more source

Transdermal Delivery of Sonidegib via Iontophoresis from PEDOT:PSS/Gelatin Hydrogels for Basal Cell Carcinoma Skin Cancer

Pharmaceutics
Background/Objectives: Skin cancers belong to the most frequent cancer type with over a million cases per year. Presently, transdermal drug delivery systems (TDDS) are an attractive drug delivery route, but they still face some limitations due to the ...
Phimchanok Sakunpongpitiporn, Johannes Schwank, Napa Parinyanitikul, Sutima Luangdilok, Nattaya Teeyapun, Aumpika Kesornsit, Anuvat Sirivat   +6 more
doaj   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, Volume 46, Issue 6, Page 1798-1823, November 2026.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source