Results 1 to 10 of about 31,257 (117)

Hedgehog inhibitors exert anti-proliferation effects and synergistically interact with trastuzumab in HER2-positive gastric cancer models [PDF]

Acta Oncologica
Background: Gastric cancer (GC) remains a significant health concern with limited therapeutic options. While trastuzumab, a Human Epidermal Growth Factor Receptor 2 (HER2)-targeting antibody, has shown efficacy in HER2-positive GC, its therapeutic ...
Zixin Yang, Ren Niu, Jinzhu Han, Jie Guo, Yingqian Lv   +4 more
doaj   +2 more sources

Hedgehog Pathway Inhibitors against Tumor Microenvironment

Cells, 2021
Targeting the hedgehog (HH) pathway to treat aggressive cancers of the brain, breast, pancreas, and prostate has been ongoing for decades. Gli gene amplifications have been long discovered within malignant glioma patients, and since then, inhibitors ...
Silpa Gampala, Jer-Yen Yang
doaj   +3 more sources

Alcian blue‐positive stromal phenotype in basal cell carcinoma is associated with progression on first‐line hedgehog inhibitors [PDF]

The Journal of Pathology: Clinical Research
Basal cell carcinoma (BCC) is the most frequent malignancy in fair‐skinned populations. Although curable in most cases, approximately 4% of patients develop locally advanced or metastatic disease (advBCC) requiring systemic therapy.
Viola K DeTemple, Rudolf Stadler, Sabine Bredemeier, Sungyoung Chung, Katrin Schaper‐Gerhardt, Mareike Alter, Yenny Angela, Henner Stege, Ulrike Leiter, Jan Ohletz, Elisabeth Livingstone, Imke vonWasielewski, Jessica C Hassel, Julia Huynh, Christoffer Gebhardt, Claudia Pföhler, Ralf Gutzmer, Christina H Scheel   +17 more
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Combined cemiplimab and radiotherapy for advanced basal cell carcinoma: A case report

SAGE Open Medical Case Reports, 2023
Advanced basal cell carcinoma may be treated with systemic therapies such as hedgehog pathway inhibitors or programmed cell death protein 1 inhibitors, namely cemiplimab.
Sidra Sarfaraz, Robert C Hayes, Anne-Marie Hunt   +2 more
doaj   +1 more source

Hedgehog signaling promotes sorafenib resistance in hepatocellular carcinoma patient-derived organoids

Journal of Experimental & Clinical Cancer Research, 2020
Background The mechanism underlying sorafenib resistance in hepatocellular carcinoma (HCC) remains unclear. Accumulating evidence suggests that tumor-initiating cells (TICs) are a pivotal driving force. Both CD44 and Hedgehog signaling play crucial roles
Siqi Wang, Yang Wang, Xiaodong Xun, Changkun Zhang, Xiao Xiang, Qian Cheng, Shihua Hu, Zhao Li, Jiye Zhu   +8 more
doaj   +1 more source

Targeted protein degradation reveals BET bromodomains as the cellular target of Hedgehog pathway inhibitor-1

Nature Communications, 2023
Target deconvolution of small molecule hits from phenotypic screens presents a major challenge. Many screens have been conducted to find inhibitors for the Hedgehog signaling pathway – a developmental pathway with many implications in health and disease –
Meropi Bagka, Hyeonyi Choi, Margaux Héritier, Hanna Schwaemmle, Quentin T. L. Pasquer, Simon M. G. Braun, Leonardo Scapozza, Yibo Wu, Sascha Hoogendoorn   +8 more
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Activation of hedgehog signaling is not a frequent event in ovarian cancers

Molecular Cancer, 2009
The hedgehog (Hh) signaling pathway regulates many processes of development and tissue homeostasis. Activation of hedgehog signaling has been reported in about 30% of human cancer including ovarian cancer.
Zhang Xiaoli, Huang Shuhong, He Jing, Yang Ling, Bian Yuehong, He Nonggao, Zhang Hongwei, Xie Jingwu   +7 more
doaj   +1 more source

Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling

Cancer Cell International, 2008
Background Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation.
Prowse David M, Shaw Greg
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Discovery of Small Molecule Inhibitors Targeting the Sonic Hedgehog

Frontiers in Chemistry, 2020
The aberrant activation of hedgehog (Hh) signaling pathway is closely related to human diseases. The upstream protein, N-terminal product of sonic hedgehog (ShhN) is overexpressed in many cancers and considered as a promising antitumor target. Inhibitors
Taikangxiang Yun, Juan Wang, Jun Yang, Wenjing Huang, Luhua Lai, Wenfu Tan, Ying Liu   +6 more
doaj   +1 more source

Antiosteogenic effect of arsenic trioxide, cholecalciferol, lovastatin or their combination in vitro [PDF]

Journal of the Serbian Chemical Society, 2019
Pathological formation of bone in non-skeletal soft tissues or heterotopic ossification (HO), for which there is currently no effective treatment, is considered to be mediated by activation of Hedgehog (Hh) signaling pathway.
Gvozdenović-Jeremić Jelena, Vert-Wong Ekaterina, Mojović Ljiljana   +2 more
doaj   +1 more source