Results 11 to 20 of about 31,386 (239)

Hedgehog pathway inhibitors – current status and future prospects [PDF]

Infectious Agents and Cancer, 2012
The Hedgehog (Hh) proteins comprise a group of secreted proteins that regulate cell growth, differentiation and survival. Inappropriate activation of the Hh signaling pathway has been implicated in the development of a variety of cancers.
Sheikh Asfandyar, Alvi Arsalan, Aslam Hafiz, Haseeb Abdul   +3 more
doaj   +3 more sources

Inhibitors of Hedgehog acyltransferase block Sonic Hedgehog signaling [PDF]

Nature Chemical Biology, 2013
Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical for Shh signaling, as a new target for Shh pathway inhibition. A target-oriented high-throughput screen was used to identify small-molecule inhibitors of Hhat.
Petrova, Elissaveta, Rios-Esteves, Jessica, Ouerfelli, Ouathek, Glickman, J. Fraser, Resh, Marilyn D.   +4 more
openaire   +2 more sources

Endocannabinoids are conserved inhibitors of the Hedgehog pathway [PDF]

Proceedings of the National Academy of Sciences, 2015
Significance Hedgehog proteins regulate development and tissue homeostasis. They signal through activation of the transmembrane protein Smoothened. Smoothened hyperactivation underlies development of many tumors. Smoothened activity can be modulated by several synthetic small molecules, which have shown promise in the clinic.
Khaliullina, H., Bilgin, M., Sampaio, J., Shevchenko, A., Eaton, S.   +4 more
openaire   +3 more sources

Repurposing the Antihelmintic Mebendazole as a Hedgehog Inhibitor [PDF]

Molecular Cancer Therapeutics, 2015
Abstract The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents. Here, we show that mebendazole, a benzamidazole with a long history of safe use against nematode infestations and hydatid disease, potently inhibited Hh signaling and slowed the ...
Andrew R, Larsen, Ren-Yuan, Bai, Jon H, Chung, Alexandra, Borodovsky, Charles M, Rudin, Gregory J, Riggins, Fred, Bunz   +6 more
openaire   +2 more sources

The dawn of hedgehog inhibitors: Vismodegib.

J Pharmacol Pharmacother, 2013
Cancer, one of the leading causes of death worldwide is estimated to increase to approximately 13.1 million by 2030. This has amplified the research in oncology towards the exploration of novel targets. Recently there has been lots of interest regarding the hedgehog (Hh) pathway, which plays a significant role in the development of organs and tissues ...
Sandhiya S, Melvin G, Kumar SS, Dkhar SA.   +3 more
europepmc   +4 more sources

Synthesis and characterisation of 5-acyl-6,7-dihydrothieno[3,2-c]pyridine inhibitors of Hedgehog acyltransferase

Data in Brief, 2016
In this data article we describe synthetic and characterisation data for four members of the 5-acyl-6,7-dihydrothieno[3,2-c]pyridine (termed “RU-SKI”) class of inhibitors of Hedgehog acyltransferase, including associated NMR spectra for final compounds ...
Thomas Lanyon-Hogg, Naoko Masumoto, George Bodakh, Antonio D. Konitsiotis, Emmanuelle Thinon, Ursula R. Rodgers, Raymond J. Owens, Anthony I. Magee, Edward W. Tate   +8 more
doaj   +1 more source

Gli1-Mediated Regulation of Sox2 Facilitates Self-Renewal of Stem-Like Cells and Confers Resistance to EGFR Inhibitors in Non–Small Cell Lung Cancer

Neoplasia: An International Journal for Oncology Research, 2015
Non–small cell lung cancer (NSCLC) patients have very low survival rates because the current therapeutic strategies are not fully effective. Although EGFR tyrosine kinase inhibitors are effective for NSCLC patients harboring EGFR mutations, patients ...
Namrata Bora-Singhal, Deepak Perumal, Jonathan Nguyen, Srikumar Chellappan   +3 more
doaj   +1 more source

Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas

BMC Veterinary Research, 2023
Background The hedgehog signalling pathway has been implicated in tumourigenesis and progression of many tumour types. This pathway has recently emerged as a therapeutic target, and inhibitors of hedgehog signalling have gained considerable attention. In
Haein Koo, Sungin Lee, Wan Hee Kim
doaj   +1 more source

Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling. [PDF]

PLoS Genetics, 2016
For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions.
Alexandre N Ermilov, Archana Kumari, Libo Li, Ariell M Joiner, Marina A Grachtchouk, Benjamin L Allen, Andrzej A Dlugosz, Charlotte M Mistretta   +7 more
doaj   +1 more source

The association of cemiplimab plus sonidegib for synchronous cutaneous squamous cell carcinoma and basal cell carcinoma of the head and neck: Two case reports

Frontiers in Oncology, 2023
Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most frequent cancers in humans, with cumulative ultraviolet radiation exposure, aging, and immunodepression as the main risk factors. In most cases, these malignancies arise
Elena Colombo, Cristina Gurizzan, Arianna Ottini, Francesca Caspani, Cristiana Bergamini, Laura D. Locati, Chiara Marchiselli, Andrea Alberti, Luigi Lorini, Lisa F. Licitra, Lisa F. Licitra, Paolo Bossi, Paolo Bossi, Carlo Resteghini   +13 more
doaj   +1 more source