Results 21 to 30 of about 31,386 (239)
Gli inhibitor pricked by Hedgehog [PDF]
Journal of Cell Biology, 2010 Tukachinsky et al. reveal how Hedgehog (Hh) signaling in the primary cilium activates the Gli family of transcription factors. ![Figure][1] Gli transcription factors (top) and their inhibitor SuFu (bottom) are recruited to cilia upon Hh stimulation (right).
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Association of Itraconazole, a Hedgehog Inhibitor, and Bladder Cancer [PDF]
Journal of Urology, 2016 Activation of Hedgehog (Hh) signaling has been implicated in early stages of bladder cancer development while loss of Hh signaling has been described during progression to more invasive disease. Itraconazole, an antifungal, is the only azole known to be a potent Hh pathway antagonist.
Ronac, Mamtani +4 more
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SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. [PDF]
PLoS ONE, 2015 Although there is much evidence showing functional relationship between Hedgehog pathway, in particular Sonic hedgehog, and SOX transcription factors during embryonic development, scarce data are available regarding their crosstalk in cancer cells. SOX18
Isidora Petrovic +5 more
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Cells, 2022 Basal cell carcinoma (BCC) is one of the most common neoplasms in the population. A good prognosis and mainly non-aggressive development have made it underdiagnosed and excluded from the statistics.
Paulina Chmiel +5 more
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Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors
Beilstein Journal of Organic Chemistry, 2012 Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity ...
Chao Che +8 more
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Design of Hedgehog pathway inhibitors for cancer treatment [PDF]
Medicinal Research Reviews, 2018 AbstractHedgehog (Hh) signaling is involved in the initiation and progression of various cancers and is essential for embryonic and postnatal development. This pathway remains in the quiescent state in adult tissues but gets activated upon inflammation and injuries.
Jitender Bariwal +3 more
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Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer
Cells, 2019 The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers.
Hao Xie +3 more
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BMC Bioinformatics, 2012 Background The Hedgehog Signaling Pathway is one of signaling pathways that are very important to embryonic development. The participation of inhibitors in the Hedgehog Signal Pathway can control cell growth and death, and searching novel inhibitors to ...
Gao Jun +4 more
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A Hedgehog inhibitor gets around [PDF]
Journal of Cell Biology, 2015 ![Figure][1] HHIP1 (red) normally amasses in the neural tube’s basement membrane (arrowheads, left), but a version of the protein that can’t bind to heparan sulfate doesn’t accumulate there (right).
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Frontiers in Pharmacology, 2022 Non-small cell lung cancer (NSCLC) is one of the most common and deadly cancers worldwide. Among NSCLC patients, almost half have wild-type epidermal growth factor receptor (EGFR WT).
Yun-Chieh Tu +6 more
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