Results 21 to 30 of about 718,149 (279)
Repurposing the Antihelmintic Mebendazole as a Hedgehog Inhibitor [PDF]
Molecular Cancer Therapeutics, 2015 Abstract The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents. Here, we show that mebendazole, a benzamidazole with a long history of safe use against nematode infestations and hydatid disease, potently inhibited Hh signaling and slowed the ...
Andrew R, Larsen +6 more
openaire +2 more sources
The hedgehog pathway inhibitor GDC-0449 shows potential in skin and other cancers [PDF]
, 2010 Background: The hedgehog signaling pathway is vital in early development, but then becomes dormant, except in some cancer tumours. Hedgehog inhibitors are being developed for potential use in cancer. Objectives/Methods: The objective of this evaluation
Doggrell, Sheila Anne, Sheila A Doggrell
core +1 more source
Neoplasia: An International Journal for Oncology Research, 2015 Non–small cell lung cancer (NSCLC) patients have very low survival rates because the current therapeutic strategies are not fully effective. Although EGFR tyrosine kinase inhibitors are effective for NSCLC patients harboring EGFR mutations, patients ...
Namrata Bora-Singhal +3 more
doaj +1 more source
Usability of serum hedgehog signalling proteins as biomarkers in canine mammary carcinomas
BMC Veterinary Research, 2023 Background The hedgehog signalling pathway has been implicated in tumourigenesis and progression of many tumour types. This pathway has recently emerged as a therapeutic target, and inhibitors of hedgehog signalling have gained considerable attention. In
Haein Koo, Sungin Lee, Wan Hee Kim
doaj +1 more source
Frontiers in Oncology, 2023 Basal cell carcinoma (BCC) and cutaneous squamous cell carcinoma (cSCC) are the most frequent cancers in humans, with cumulative ultraviolet radiation exposure, aging, and immunodepression as the main risk factors. In most cases, these malignancies arise
Elena Colombo +13 more
doaj +1 more source
Indian hedgehog (Ihh) both promotes and restricts thymocyte differentiation [PDF]
, 2009 We show that Indian Hedgehog (Ihh) regulates T-cell development and homeostasis in both fetal and adult thymus, controlling thymocyte number. Fetal Ihh-/- thymi had reduced differentiation to double-positive (DP) cell and reduced cell numbers compared ...
Outram, Susan V +17 more
core +1 more source
Long-term strategies for management of advanced basal cell carcinoma with hedgehog inhibitors
, 2023 Basal cell carcinoma (BCC), the most common type of skin cancer, is characterized by aberrant activation of the hedgehog molecular pathway. Systemic therapy is indicated when local approaches, such as surgery and radiation, are inappropriate.
Stratigos, Alex +16 more
core +3 more sources
Maintenance of Taste Organs Is Strictly Dependent on Epithelial Hedgehog/GLI Signaling. [PDF]
PLoS Genetics, 2016 For homeostasis, lingual taste papilla organs require regulation of epithelial cell survival and renewal, with sustained innervation and stromal interactions.
Alexandre N Ermilov +7 more
doaj +1 more source
Cells, 2022 Basal cell carcinoma (BCC) is one of the most common neoplasms in the population. A good prognosis and mainly non-aggressive development have made it underdiagnosed and excluded from the statistics.
Paulina Chmiel +5 more
doaj +1 more source
Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Chapple, JP, Knight, MM, Thompson, CL
core +1 more source