Results 31 to 40 of about 718,149 (279)

SOX18 Is a Novel Target Gene of Hedgehog Signaling in Cervical Carcinoma Cell Lines. [PDF]

PLoS ONE, 2015
Although there is much evidence showing functional relationship between Hedgehog pathway, in particular Sonic hedgehog, and SOX transcription factors during embryonic development, scarce data are available regarding their crosstalk in cancer cells. SOX18
Isidora Petrovic, Milena Milivojevic, Jelena Popovic, Marija Schwirtlich, Branislava Rankovic, Milena Stevanovic   +5 more
doaj   +1 more source

Effect of sonic hedgehog/β-TCP composites on bone healing within the critical-sized rat femoral defect [PDF]

, 2013
The creation of entirely synthetically derived bone substitute materials which are as effective as autologous bone grafts is desirable. Osteogenesis involves the concerted action of several proteins within a signaling cascade.
Henrich, Dirk, Marzi, Ingo, Seebach, Caroline, Flinspach, Armin Niklas, Wenger, Florian, Warzecha, Jörg   +5 more
core   +1 more source

Hedgehog pathway inhibition and the race against tumor evolution [PDF]

, 2012
Dependence of basal cell carcinomas and medulloblastomas on the Hedgehog pathway provides an opportunity for targeted or "personalized" therapy. The recent effectiveness and FDA approval of the first Smoothened inhibitors validates this class of agents ...
Scott X. Atwood, Chang, Anne Lynn S, Oro, Anthony E, Anthony E. Oro, Atwood, Scott X, Anne Lynn S. Chang   +5 more
core   +1 more source

Synthesis and characterization of Sant-75 derivatives as Hedgehog-pathway inhibitors

Beilstein Journal of Organic Chemistry, 2012
Sant-75 is a newly identified potent inhibitor of the hedgehog pathway. We designed a diversity-oriented synthesis program, and synthesized a series of Sant-75 analogues, which lays the foundation for further investigation of the structure–activity ...
Chao Che, Song Li, Bo Yang, Shengchang Xin, Zhixiong Yu, Taofeng Shao, Chuanye Tao, Shuo Lin, Zhen Yang   +8 more
doaj   +1 more source

Integrated QSAR study for inhibitors of hedgehog signal pathway against multiple cell lines:a collaborative filtering method

BMC Bioinformatics, 2012
Background The Hedgehog Signaling Pathway is one of signaling pathways that are very important to embryonic development. The participation of inhibitors in the Hedgehog Signal Pathway can control cell growth and death, and searching novel inhibitors to ...
Gao Jun, Che Dongsheng, Zheng Vincent W, Zhu Ruixin, Liu Qi   +4 more
doaj   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer

Cells, 2019
The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers.
Hao Xie, Brooke D. Paradise, Wen Wee Ma, Martin E. Fernandez-Zapico   +3 more
doaj   +1 more source

Hedgehog Suppresses Paclitaxel Sensitivity by Regulating Akt-Mediated Phosphorylation of Bax in EGFR Wild-Type Non-Small Cell Lung Cancer Cells

Frontiers in Pharmacology, 2022
Non-small cell lung cancer (NSCLC) is one of the most common and deadly cancers worldwide. Among NSCLC patients, almost half have wild-type epidermal growth factor receptor (EGFR WT).
Yun-Chieh Tu, Wei-Chen Yeh, Hsin-Hsien Yu, Hsin-Hsien Yu, Yu-Cheng Lee, Bor-Chyuan Su, Bor-Chyuan Su   +6 more
doaj   +1 more source

Metastatic and locally aggressive BCC: Current treatment options

Clinical Case Reports, 2021
The treatment of locally advanced and metastatic BCC presents a significant clinical challenge. Treatment options have evolved recently to include the use of hedgehog inhibitors Vismodigib and Sonidigib and immunotherapy with Cemiplimab.
Máire‐Caitlín Casey, Roisín Pollock, Rachel H Enright, James Paul O'Neill, Neville Shine, Paul Sullivan, Fiachra T Martin, Barry O'Sullivan   +7 more
doaj   +1 more source

The Binding Mode of the Sonic Hedgehog Inhibitor Robotnikinin, a Combined Docking and QM/MM MD Study

Frontiers in Chemistry, 2017
Erroneous activation of the Hedgehog pathway has been linked to a great amount of cancerous diseases and therefore a large number of studies aiming at its inhibition have been carried out. One leverage point for novel therapeutic strategies targeting the
Manuel Hitzenberger, Manuel Hitzenberger, Daniela Schuster, Thomas S. Hofer   +3 more
doaj   +1 more source