Results 41 to 50 of about 2,348 (179)

Sonidegib: Safety and Efficacy in Treatment of Advanced Basal Cell Carcinoma [PDF]

Dermatology and Therapy, 2020
Hedgehog inhibitors are promising alternative treatments for patients with advanced basal cell carcinomas. Sonidegib (Odomzo®), an oral smoothened (SMO) antagonist, is indicated for the treatment of adult patients with locally advanced basal cell carcinoma (laBCC) who present recurrence following surgery or radiation therapy, or those who are not ...
Villani A., Fabbrocini G., Costa C., Scalvenzi M.   +3 more
openaire   +4 more sources

Locally advanced basosquamous carcinoma: Our experience with sonidegib

Dermatologic Therapy, 2022
N ...
Toffoli, Ludovica, Agozzino, Marina, di Meo, Nicola, Zalaudek, Iris, Conforti, Claudio   +4 more
openaire   +4 more sources

Clinical Clearance Following Improvement of Histologic Subtype of Basal Cell Carcinoma with Sonidegib

Acta Dermato-Venereologica, 2022
is missing (Short communication)
Liang Joo Leow, Vicki Howard
doaj   +1 more source

Sonidegib for management of periocular basal cell carcinoma: case report and literature review

Academia Oncology
Treatment of periocular basal cell carcinoma (BCC) is difficult due to proximity to critical structures, including the eye and intracranial areas.
Elizabeth Fan, Kali Morrissette, Sakshi Chopra, Stephanie Hendren, Michelle Pavlis   +4 more
doaj   +1 more source

A Review of Hedgehog Inhibitors Sonidegib and Vismodegib for Treatment of Advanced Basal Cell Carcinoma

, 2021
Basal cell carcinoma (BCC) is the most common malignancy in fair-skinned populations. Most cases are successfully treated with surgery, but in advanced BCC—including locally advanced BCC and metastatic BCC—surgery is likely to result in substantial ...
Farberg, Aaron, Migden, Michael, Hanke, C William, Squittieri, Nicholas, Dummer, Reinhard   +4 more
core   +1 more source

Targeted Delivery of 5-Fluorouracil and Sonidegib via Surface-Modified ZIF-8 MOFs for Effective Basal Cell Carcinoma Therapy

Pharmaceutics, 2023
The therapeutic effectiveness of the most widely used anticancer drug 5-fluorouracil (5-FU) is constrained by its high metabolism, short half-life, and rapid drug resistance after chemotherapy.
Bharath Singh Padya, Gasper Fernandes, Sumukha Hegde, Sanjay Kulkarni, Abhijeet Pandey, Praful Balavant Deshpande, Sheikh F. Ahmad, Dinesh Upadhya, Srinivas Mutalik   +8 more
doaj   +1 more source

AI‐Driven Synthesis in Medicinal Chemistry: Integrating Large Language Models, Robotic Automation, and Sustainability Metrics to Accelerate Drug Discovery

Medicinal Research Reviews, EarlyView.
ABSTRACT Artificial intelligence (AI) is transforming synthetic chemistry from task‐specific predictors into integrated platforms that unify retrosynthesis, reaction optimization, and closed‐loop robotic automation. This review highlights how AI‐assisted planning and robotic execution shorten cycle times, reduce step counts, and improve route ...
Amit Gangwal, Antonio Lavecchia
wiley   +1 more source

Sonidegib and vismodegib in the treatment of patients with locally advanced basal cell carcinoma: a joint expert opinion [PDF]

, 2020
Sonidegib and vismodegib are hedgehog pathway inhibitors (HhIs) approved for the treatment of advanced basal cell carcinoma (BCC). Until recently, vismodegib was the only targeted treatment available for patients with locally advanced BCC (laBCC) in ...
Dummer, R, J.T. Lear, Basset- Seguin, N, Schadendorf, D, R. Krattinger, R. Dummer, Grob, J, Grob, R J J, Krattinger, R, R. Gutzmer, D. Schadendorf, C. Garbe, J.J. Grob, P.A. Ascierto, Dréno, B, J. Malvehy, Lear, J T, Ascierto, P, Malvehy, J, Gutzmer, R, Lear, J, Basset-Seguin, N, B. Dréno, N. Basset‐Seguin, Ascierto, P A, Hauschild, A, A. Hauschild, Garbe, C   +27 more
core   +1 more source

Sustained Suppression of Gorlin Syndrome-Associated Basal Cell Carcinomas with Vismodegib or Sonidegib: A Case Series

Current Oncology, 2023
Nevoid basal-cell carcinoma syndrome (Gorlin syndrome) is characterized by numerous cutaneous basal cell carcinomas mediated by mutations in the hedgehog pathway. Vismodegib or sonidegib represent promising treatment options.
Raquel Wescott, Wolfram Samlowski
doaj   +1 more source

Sphingosine‐1‐Phosphate Receptor 1 Regulates Competition Dependent Astrocyte Morphogenesis and Tiling in Murine Cortex

Glia, Volume 74, Issue 8, August 2026.
Neuronal contact‐induced expression of S1PR1 in astrocytes is regulated by JAK‐STAT3 signaling. Astrocytic S1PR1 modulates cortical astrocyte morphogenesis. Astrocytic S1PR1 regulates astrocyte territorial overlap/tiling in a competition dependent manner.
Jean Patrick M. Gonzales, Connor Tuck, Surya Chandra Rao Thumu, Soha Munir, Jaden Harris, Hunain (Zeik) Tariq, Paul Marcelli, Oscar Dominguez, Kaviya Suriyakumar Anbazagan, Sandeep K. Singh   +9 more
wiley   +1 more source