Results 51 to 60 of about 2,348 (179)

Toward Sustainable Carbonylation Reactions Enabled by CO Surrogates in Green Solvents

ChemSusChem, Volume 19, Issue 13, 14 July 2026.
Carbonylation reactions offer a sustainable route to valuable carbonyl compounds. This review highlights methodologies that exploit carbonylative coupling to drastically enhance process sustainability, avoiding the direct use of CO through CO surrogates and promoting syntheses in green solvents potentially derived from renewable and sustainable sources.
Francesco Messa, Serena Perrone, Antonio Salomone   +2 more
wiley   +1 more source

Clinical and economic benefits of using sonidegib in the 1-line therapy of patients with locally advanced basal cell carcinoma

Фармация и фармакология (Пятигорск)
One of the key factors in ensuring the availability of modern treatments and choosing the optimal therapy for patients is the clinical and economic characteristics of new medical technologies.The aim: to assess the clinical and economic feasibility of ...
O. I. Ivakhnenko, V. V. Ryazhenov, M. Yu. Frolov, V. A. Rogov   +3 more
doaj   +1 more source

24 | Management of advanced basal cell carcinoma with hedgehog inhibitors: a real-world prospective comparative study

Dermatology Reports
Background: Hedgehog Pathway Inhibitors (HHIs) should be offered to patients with advanced BCC as a first line treatment. Two systemic HHIs are currently available: sonidegib and vismodegib.
Italian Melanoma Intergroup
doaj   +1 more source

Oncofetal Biology: From Fundamental Mechanisms to Emerging Therapeutic Opportunities

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oncofetal biology provides a transformative framework for understanding cancer initiation, progression, and therapeutic intervention. This review synthesizes the core molecular mechanisms connecting embryonic development and tumorigenesis from a multidisciplinary standpoint and outlines future research trajectories and clinical applications, and we aim
Yang Liu, Kaifeng Niu, Qingran Kong, Shaorong Gao   +3 more
wiley   +1 more source

25 | A phase II, open-label study to improve compliance and time of treatment after obtaining complete response through a tailored schedule of sonidegib in locally advanced basal cell carcinomas – the SONIBEC trial

Dermatology Reports
Background: Sonidegib is an effective treatment for laBCC, but it is associated with a risk of treatment-related adverse events (TRAEs), causing treatment discontinuation.
Italian Melanoma Intergroup
doaj   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, Volume 13, Issue 29, 22 May 2026.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

The safety and efficacy of sonidegib for the treatment of locally advanced basal cell carcinoma

, 2016
Introduction: Basal cell carcinomas (BCCs) are the commonest malignancy in the Western world. Locally advanced BCCs (laBCCs) represent tumours that have developed in difficult-to-treat facial sites, aggressively recurrent tumours, large neglected tumours
Lear, John T., Ali, Faisal R., Collier, Nicholas J.   +2 more
core   +1 more source

Integrated Molecular Profiling Improves Subtype Classification and Reveals Inherited Susceptibility in Medulloblastoma: Insights From a Real‐World Cohort

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT Background Medulloblastoma (MB) is a heterogeneous pediatric brain tumor characterized by distinct molecular subtypes. Although genomics and transcriptomics have improved subtype classification and informed targeted therapies, the clinical utility of integrated molecular profiling in real‐world settings remains incompletely defined. Methods We
Jiwei Song, Tiantian Han, Siqi Chen, Dongsheng Chen, Ziying Liu   +4 more
wiley   +1 more source

Long-term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42-month analysis of the phase II randomized, double-blind BOLT study [PDF]

, 2020
Background: Basal cell carcinomas (BCCs) exhibit aberrant activation of the hedgehog pathway. Sonidegib is a hedgehog pathway inhibitor approved for the treatment of locally advanced BCC (laBCC) and metastatic BCC (mBCC) based on primary results of the ...
Plummer, R., Squittieri, N., Guminksi, A., Dummer, R., Kudchadkar, R., Schulze, H.-J., Migden, M.R., Stratigos, A.J., Chang, A.L.S., Trefzer, U., Loquai, C., Lewis, K.D., Combemale, P., Dirix, L., Lear, J.T., Gutzmer, R., Kaatz, M.   +16 more
core   +2 more sources

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source