Results 71 to 80 of about 2,348 (179)

HOXB4 Promotes Bladder Cancer Progression in Part Through Transcriptional Activation of Smoothened

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
HOXB4 is overexpressed in bladder cancer and associated with poor prognosis. By transcriptionally activating Smoothened (SMO), HOXB4 amplifies SMO–GLI signaling to promote tumor growth and metastatic behavior. This graphical abstract highlights the HOXB4–SMO axis as a key driver of bladder cancer progression and a potential target for future ...
Zhaoheng Jin, Wenjie Yang, Yueqiang Peng, Lin Ma, Ziyi Li, Jie Dong, Zhigang Ji   +6 more
wiley   +1 more source

A Phase 1, Multicenter, Open-Label, First-in-Human, Dose-Escalation Study of the Oral Hedgehog Inhibitor Sonidegib (LDE225) in Patients With Advanced Solid Tumors [PDF]

, 2014
PURPOSE: This phase 1 trial was undertaken to determine the maximum tolerated dose (MTD), dose-limiting toxicities (DLTs), safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of the novel smoothened inhibitor
D Mahalingam (7806581), Shou, Y, Amakye, DD, Mahalingam, D, Stoller, RG, J Rodon (7806563), RG Stoller (7806569), Hurh, E, J Sarantopoulos (7806578), Rose, KL, Moles, Melissa A, HA Tawbi (7806566), L Yang (6502793), R Dummer (7806602), Yang, L, J Baselga (7806575), Granvil, Camille, Amakye, Dereck D, AL Thomas (7661462), Baselga, Jose, Thomas, Anne L, CP Turtschi (7806572), Shou, Yaping, Rose, Kristine L, KL Rose (7806596), Dummer, Reinhard, Rodon, J, Mita, AC, C Granvil (7806590), Moles, MA, Thomas, AL, Sarantopoulos, J, Dummer, R, AC Mita (7806605), DD Amakye (7806599), Rodon, Jordi, Mahalingam, Devalingam, E Hurh (7806593), Tawbi, HA, Turtschi, CP, Granvil, C, Y Shou (7806584), Sarantopoulos, John, Turtschi, Christian P, MA Moles (7806587), Mita, Alain C, Yang, Lin, Hurh, Eunju, Tawbi, Hussein A, Stoller, Ronald, Baselga, J   +50 more
core   +1 more source

Effects of Mild to Severe Hepatic Impairment on the Pharmacokinetics of Sonidegib: A Multicenter, Open-Label, Parallel-Group Study

, 2017
BACKGROUND AND OBJECTIVE: Sonidegib is a potent, selective and orally bioavailable inhibitor of the Hedgehog signaling pathway, primarily metabolized by the liver.
Liudmila, Mateva, Mateva Liudmila, Castro, Henry, Sellami, Dalila, Jocelyn Zhou, Preston, Richard A, Zhou, Jocelyn, Horsmans, Yves, Golor, George, Shibolet, Oren, George Golor, Hildegard Boss, Henry Castro, Boss, Hildegard, Emotte, Corinne, Corinne Emotte, Yves Horsmans, Quinlan, Michelle, Michelle Quinlan, Dalila Sellami, Preston, Richard A., Richard A. Preston, Oren Shibolet   +22 more
core   +1 more source

Different Response of Ptch Mutant and Ptch Wildtype Rhabdomyosarcoma Toward SMO and PI3K Inhibitors

Frontiers in Oncology, 2018
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma with poor prognosis. RMS frequently show Hedgehog (HH) pathway activity, which is predominantly seen in the embryonal subtype (ERMS).
Natalie Geyer, Rosalie Ridzewski, Julia Bauer, Maria Kuzyakova, Kai Dittmann, Christian Dullin, Albert Rosenberger, Hans-Ulrich Schildhaus, Anja Uhmann, Simone Fulda, Heidi Hahn   +10 more
doaj   +1 more source

Survey of the impact of BOLT-trial data on oncologists’ and dermatologists’ decision-making in treating patients with locally advanced basal cell carcinoma

Dermatology Reports
Basal cell carcinoma (BCC) is the most common malignant tumour in white populations. Multiple studies demonstrated that the aberrant activation of Hedgehog signaling is a driver of BCC development, and its blockade represents a potential therapeutic ...
Luigi Scarpato, Marco Palla, Sabino Strippoli, Luca Tagliaferri, Luca Fania, Maristella Saponara, Anna Carbone, Francesco Spagnolo, Flavia Silvestri, Paolo Antonio Ascierto   +9 more
doaj   +1 more source

First reported case of concurrent sonidegib and radiotherapy for recurrent, advanced basal cell carcinoma

, 2021
Basal cell carcinoma (BCC ) is the most common human malignancy. Systemic therapy with a sonic hedgehog (SHH) pathway inhibitor plays an important role in the treatment of advanced BCC .
Prabhu, Arpan V.; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas,United States, Wang, Kaidi; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas,United States, Patel, Mausam; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas,United States, Lewis, Gary D.; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, Arkansas,United States   +3 more
core   +1 more source

Targeting Hedgehog (Hh) Pathway for the Acute Myeloid Leukemia Treatment

Cells, 2019
The Hedgehog (Hh) pathway, containing the Patched (PTCH) and Smoothened (SMO) multitransmembrane proteins, is the main regulator of vertebrate embryonic development.
Toshiki Terao, Yosuke Minami
doaj   +1 more source

Interim analysis of the multinational, post-authorization safety study (NISSO) to assess the long-term safety of sonidegib in patients with locally advanced basal cell carcinoma

BMC Cancer
Background Following the pivotal phase II trial BOLT, the Hedgehog (Hh) inhibitor sonidegib was approved in the EU to treat locally advanced basal cell carcinoma (laBCC) in patients not amenable to surgery or radiotherapy.
Ralf Gutzmer, Ulrike Leiter, Peter Mohr, Katharina C. Kähler, Paolo Antonio Ascierto, Massimiliano Scalvenzi, Ketty Peris, Gemma María Pérez-Pastor, Ricardo Fernández-de-Misa, Rafael Botella-Estrada, Robert E. Hunger, Serena Martelli, Nur Güneli, Ramon Arntz, Axel Hauschild   +14 more
doaj   +1 more source

Basal Cell Nevus Syndrome Treated With Laser Therapy: Novel Approach for Young Adults

International Journal of Dermatology, Volume 65, Issue 2, Page 362-364, February 2026.
Giulia Briatico, Camila Scharf, Eugenia Veronica Di Brizzi, Gabriella Brancaccio, Nikola Drmac   +4 more
wiley   +1 more source

Recent Advances in the Clinical Targeting of Hedgehog/GLI Signaling in Cancer

Cells, 2019
The Hedgehog/GLI signaling pathway plays an important role in normal embryonic tissue development and has been implicated in the pathogenesis of various human cancers.
Hao Xie, Brooke D. Paradise, Wen Wee Ma, Martin E. Fernandez-Zapico   +3 more
doaj   +1 more source