Results 61 to 70 of about 6,536 (227)

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Aptamer‐Engineered Liposomal Platform Enables in Situ cDC1 Vaccination to Potentiate Immunotherapy in Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer is immunologically ‘cold’, with scarce, dysfunctional type 1 conventional dendritic cells (cDC1s) that limit T cell priming. We introduce an aptamer‐targeted liposomedelivering FMS‐like tyrosine kinase 3 ligand (Flt3L) and chlorin e6 (Ce6). Ultrasound induces antigen release and cDC1s recruitment, creating an in situ cDC1 vaccine.
Jiayi Wang, Xuan Wang, Xinfeng Dai, Linxin Tian, Wencheng Shen, Xueliang Liu, Wei Xue, Jiahua Pan, Yu Yang   +8 more
wiley   +1 more source

Defect‐Rich 2D Layered Double Hydroxides Enhance Sonodynamic Antibacterial Therapy

Advanced Science, EarlyView.
This study develops defect‐rich ultrathin ZnCuW‐LDH nanosheets (DR‐ZnCuW‐LDH) via acid etching. DR‐ZnCuW‐LDH exhibits fourfold enhanced US‐triggered ROS production due to oxygen defects and electronic modulation, demonstrating potent antibacterial efficacy in vitro/vivo.
Qian Liu, Yu Yang, Rui Zhao, Linwei Huang, Xingyu Qi, Min Wu, Jianliang Shen   +6 more
wiley   +1 more source

Sonodynamic therapy with photosensitizers and its combination with photodynamic therapy in treatment of malignant tumors

Biomedical Photonics, 2014
The article reviews mechanisms of sonodynamic therapy with photosensitizers (ultrasound + photosensitizer) and combination of sonodynamic with photodynamic therapy (ultrasound + photosensitizer + light exposure) for treatment of malignant tumors ...
D. A. Zerkovskiy, E. N. Alexandrova, T. P. Laptsevich, Ju. P. Istomin   +3 more
doaj   +2 more sources

Development and characterisation of disulfiram-loaded PLGA nanoparticles for the treatment of non-small cell lung cancer [PDF]

, 2017
Non-Small Cell Lung Cancer (NSCLC) is the most common type of lung cancer in both men and women. A recent phase IIb study demonstrated that disulfiram (DSF) in combination with cisplatin and vinorelbine was well tolerated and prolonged the survival of ...
Ahmed, Zahima, Iqbal, Mohammed, McConville, Christopher, Najlah, Mohammad, Tawari, Patrica, Wang, Weiguang, Wang, Zhipeng   +6 more
core   +2 more sources

Advances and Challenges in Micro/Nanocarrier‐Based Dermal Drug Delivery Systems for Acne Treatment

Advanced NanoBiomed Research, EarlyView.
Topical acne treatment faces challenges from skin barriers and complex causes. Micro/nanocarriers improve drug delivery by enhancing bioavailability, targeting, and duration. Combining carriers creates synergistic effects for systematic intervention.
Jintao Yang, Jie Chen, Yunmiao Ma, Qingwei Zhou, Yu Kong, Yingxiang Chen, Junjie Chi, Haihua Hu   +7 more
wiley   +1 more source

Antibacterial Applications of Black and Violet Phosphorus‐Based Biomaterials

Advanced NanoBiomed Research, EarlyView.
Black and violet phosphorus‐based biomaterials exhibit broad‐spectrum antibacterial efficacy in various infections, including bone, skin, ocular, dental, lung, and sepsis cases. Their antibacterial mechanisms include physical disruption, light‐driven effects, targeted drug delivery, and enhanced composite strategies.
Zhuo Dai, Yu Zhang, Xiaoye Li, Ao He, Qiang Li, Weijun Xiu, Yongbin Mou, Heng Dong, Meng Ding   +8 more
wiley   +1 more source

Sonodynamic therapy-based nanoplatforms for combating bacterial infections

Ultrasonics Sonochemistry, 2023
The rapid spread and uncontrollable evolution of antibiotic-resistant bacteria have already become urgent global to treat bacterial infections. Sonodynamic therapy (SDT), a noninvasive and effective therapeutic strategy, has broadened the way toward dealing with antibiotic-resistant bacteria and biofilms, which base on ultrasound (US) with ...
Pei-Yao Xu, Ranjith Kumar Kankala, Shi-Bin Wang, Ai-Zheng Chen   +3 more
openaire   +3 more sources

Investigation into the Sonodynamic Activity of Three Newly Synthesized Derivatives of Ciprofloxacin

Molecules
Sonosensitizers play a crucial role in the efficacy of sonodynamic antitumor therapy (SDT) and sonodynamic antimicrobial chemotherapy (SACT), highlighting the necessity for the development of new compounds with good sonodynamic activity.
Ying Zheng, Jing Lv, Jun Zhang, Yu Liu, Xiaofang Wang, Bin Liu   +5 more
doaj   +1 more source

Using C-doped TiO₂ Nanoparticles as a Novel Sonosensitizer for Cancer Treatment

Antioxidants, 2020
Sonodynamic therapy is an effective treatment for eliminating tumor cells by irradiating sonosentitizer in a patient’s body with higher penetration ultrasound and inducing the free radicals.
Chun-Chen Yang, Chong-Xuan Wang, Che-Yung Kuan, Chih-Ying Chi, Ching-Yun Chen, Yu-Ying Lin, Gin-Shin Chen, Chun-Han Hou, Feng-Huei Lin   +8 more
doaj   +1 more source