Results 131 to 140 of about 126,024 (329)

N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

Molecular Cancer, 2020
Background and aims Accumulating evidence suggests that the primary and acquired resistance of hepatocellular carcinoma (HCC) to sorafenib is mediated by multiple molecular, cellular, and microenvironmental mechanisms. Understanding these mechanisms will
Junjie Xu, Zhe Wan, M. Tang, Zhongjie Lin, Shi Jiang, Lin Ji, Kirill Gorshkov, Qijiang Mao, Shun-jie Xia, D. Cen, Junhao Zheng, X. Liang, Xiujun Cai   +12 more
semanticscholar   +1 more source

Toward Predictable Nanomedicine: Current Forecasting Frameworks for Nanoparticle–Biology Interactions

Advanced Intelligent Discovery, EarlyView.
Predictive models successfully screen nanoparticles for toxicity and cellular uptake. Yet, complex biological dynamics and sparse, nonstandardized data limit their accuracy. The field urgently needs integrated artificial intelligence/machine learning, systems biology, and open‐access data protocols to bridge the gap between materials science and safe ...
Mariya L. Ivanova, Michael Nicholls, Nicola Russo, Gueorgui Mihaylov, Konstantin Nikolic   +4 more
wiley   +1 more source

Co-targeting of DNA, RNA, and protein molecules provides optimal outcomes for treating osteosarcoma and pulmonary metastasis in spontaneous and experimental metastasis mouse models. [PDF]

, 2017
Metastasis is a major cause of mortality for cancer patients and remains as the greatest challenge in cancer therapy. Driven by multiple factors, metastasis may not be controlled by the inhibition of single target.
DeVere White, Ralph W, Duan, Zhijian, Ho, Pui Yan, Jian, Chao, Lam, Kit S, Lara, Primo N, Qiu, Jing-Xin, Tu, Mei-Juan, Wun, Theodore, Yu, Ai-Ming, Yu, Ai-Xi, Zhang, Qianyu   +11 more
core   +1 more source

Optimization and Characterization of Aspirin‐ and Ibuprofen‐Loaded Lipid‐Based Nanoparticle Synthesis for Antibacterial Activity and Cytotoxic Effect

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Lipid‐based nanoparticles (LNPs) are favored for drug delivery because of their low toxicity, high biocompatibility, ability to self‐assemble into nanoparticles, and ability to enhance drug bioavailability, thereby improving drug release modulation and pharmacokinetics.
Gulizar Caliskan, Smyrna Ergonul, Zuhal Naz Cansu, Busra Kaplan   +3 more
wiley   +1 more source

Multiple Roles of Autophagy in the Sorafenib Resistance of Hepatocellular Carcinoma

Cellular Physiology and Biochemistry, 2017
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide, and prognosis remains unsatisfactory since the disease is often diagnosed at the advanced stages.
Ting Sun, Hongchun Liu, Liang Ming
doaj   +1 more source

A real-time proximity querying algorithm for haptic-based molecular docking [PDF]

, 2014
Intermolecular binding underlies every metabolic and regulatory processes of the cell, and the therapeutic and pharmacological properties of drugs.
Bayazit, Berman, Brooks, Brooks Jr, Chen, Daunay, Davies, Delano, Eisenstein, Ferrin, Férey, Férey, Georgios Iakovou, Hou, Humphrey, Jackins, Krenek, Lai-Yuen, Leach, Lee, Lin, Moitessier, Nagata, Otaduy, Pattabiraman, Pettersen, Rizzo, Salisbury, Sauer, Sayle, Schmid, Schneidman-Duhovny, Schuttelkopf, Sourina, Stephen Laycock, Steven Hayward, Stocks, Stocks, Stone, Subasi, Teschner, Weiner, Wollacott, Yuriev, Zonta   +44 more
core   +1 more source

Impact of Viral Status on Survival in Patients Receiving Sorafenib for Advanced Hepatocellular Cancer: A Meta-Analysis of Randomized Phase III Trials [PDF]

, 2017
Purpose: Following the Sorafenib Hepatocellular Carcinoma Assessment Randomized Protocol (SHARP) trial, sorafenib has become the standard of care for patients with advanced unresectable hepatocellular carcinoma, but the relation between survival ...
Berhane, S, Jackson, R, Johnson, PJ, Khan, H, Psarelli, EE   +4 more
core   +2 more sources

Immune-Based Combinations versus Sorafenib as First-Line Treatment for Advanced Hepatocellular Carcinoma: A Meta-Analysis [PDF]

, 2023
Alessandro Rizzo, Angela Dalia Ricci, Annarita Fanizzi, Raffaella Massafra, Raffaele De Luca, Giovanni Brandi   +5 more
openalex   +1 more source

Analysis of SWI Complex Subunits in 69 Cases of TTF‐1 Negative Non‐Small Cell Lung Carcinoma

Diagnostic Cytopathology, EarlyView.
ABSTRACT Non‐small cell lung carcinomas, not otherwise specified (NSCLC‐NOS) with a specific signature including high‐grade hepatoid/clear cell morphology, negative lung panel mutational analysis, negative TTF‐1/Napsin A staining can be reported as a morphologic variant of an aggressive carcinoma with loss of one of the subunits of the SWI/SNF ...
Ramin Zargham, Feng (Selina) Ji, Tarek Bismar   +2 more
wiley   +1 more source

RETRACTED ARTICLE: LATS2 overexpression attenuates the therapeutic resistance of liver cancer HepG2 cells to sorafenib-mediated death via inhibiting the AMPK–Mfn2 signaling pathway

Cancer Cell International, 2019
Background Effective therapy for hepatocellular carcinoma (HCC) is currently an imperative issue, and sorafenib is a first-line drug for the treatment of HCC. However, the clinical benefit of sorafenib is often impaired by drug resistance.
Jie Song, Wei Zhao, Chang Lu, Xue Shao
doaj   +1 more source