Results 131 to 140 of about 53,966 (229)

Current Status of Multidisciplinary Treatment Strategies for Hepatocellular Carcinoma in the Era of Advanced Systemic Therapies

Annals of Gastroenterological Surgery, Volume 10, Issue 2, Page 325-335, March 2026.
ABSTRACT The therapeutic landscape of hepatocellular carcinoma (HCC) has been transformed by recent advancements in systemic therapies, particularly with the introduction of immune checkpoint inhibitors, expanding treatment options beyond conventional locoregional approaches.
Keiichi Akahoshi, Shun Kaneko, Shinji Tanaka, Minoru Tanabe, Daisuke Ban   +4 more
wiley   +1 more source

Sorafenib nanomedicine in HCC: nano-bio interactions and combination therapies. [PDF]

J Nanobiotechnology
Lu T, Zhu W, Lin C, Zhang Z, Lim LHK, Cui J.   +5 more
europepmc   +1 more source

Renal‐Limited Thrombotic Microangiopathy due to Anti‐VEGF/TKI Immunotherapy for Metastatic Renal Cell Carcinoma Presenting as Nephrotic Syndrome: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Vascular endothelial growth factor (VEGF) inhibition may result in proteinuria, worsening hypertension, chronic kidney injury, or glomerular disease. Recently, systemic VEGF inhibition has been reported to cause nephrotic disorders and thrombotic microangiopathy (TMA).
Sundus Sardar, Ahmad Matarneh, Omar K. Salameh, Abdel‐Rauof M. Akkari, Monika Joshi, Erik Washburn, Nasrollah Ghahramani, Naman Trivedi   +7 more
wiley   +1 more source

Hepatic arterial infusion chemotherapy (HAlC) versus sorafenib for hepatocellular carcinoma (HCC) in Barcelona Clinic Liver Cancer (BCLC) B/C: A systematic review and meta-analysis. [PDF]

PLoS One
Chen Z, Fan Y, Luo Y, Ye X, You Z.
europepmc   +1 more source

Molecular Characteristics, Potential Mechanisms, and Prognostic Gene Model of Younger Female Patients With Gastric Cancer

Cancer Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background Male patients were twice as likely to develop gastric cancer (GC) compared to females, partly due to the protective effect of estrogen. However, the proportion of females increased in the young GC patients. Aims The study was designed to explore comprehensive molecular profiles of younger female GC patients, as well as develop a ...
Xiaoyi Luan, Lulu Zhao, Wanqing Wang, Penghui Niu, Xue Han, Zerong Wang, Xiaojie Zhang, Dongbing Zhao, Yingtai Chen   +8 more
wiley   +1 more source

Advances in Systemic Therapy for Unresectable Hepatocellular Carcinoma: Commentary on The Impact of the STRIDE Regimen in HIMALAYA Trial. [PDF]

Oncol Res
Abdulgader L, Esmail A.
europepmc   +1 more source

Integrated Experimental and Computational Study of a Novel Benzimidazolium Salt: Crystal Structure, Antiproliferative Activity on Human Cancer Cell Lines, DFT Analysis, VEGFR2 Molecular Docking and VEGFR2‐Targeted Molecular Dynamics Simulations

Crystal Research and Technology, Volume 61, Issue 3, March 2026.
A novel benzimidazolium salt, compound 4, is synthesized and structurally characterized by spectroscopic and crystallographic methods. The compound exhibits antiproliferative activity against five human cancer cell lines. Computational studies reveal favorable VEGFR2 binding, stable protein–ligand interactions, and electronic features that support its ...
Gulay Dilek
wiley   +1 more source

Alcohol induces sorafenib resistance in hepatocellular carcinoma: A translational study. [PDF]

J Mol Med (Berl)
Courtois A, Marié C, Fouquet G, Diouf M, Esparteiro D, Ducournau G, Marticho L, Naassila M, Nguyen-Khac E, Marcq I.   +9 more
europepmc   +1 more source

The multifaceted roles of the ACSL family in cancer: Metabolic reprogramming, ferroptosis regulation and tumour immune microenvironment remodelling

Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.
The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li, Weijian Wang, Juncheng Zhan, Yuxiang Xiao, Xiaoping Chen, Chen Su, Peng Zhu   +6 more
wiley   +1 more source

Microfluidic Encapsulation of Sorafenib-Loaded ZIF-8 Nanoparticles in pH-Responsive Alginate Microparticles for Oral Chemotherapy of Hepatocellular Carcinoma. [PDF]

ACS Appl Bio Mater
Mirshafiei M, Mahmoudi Z, Mehrpouya M, Mahmoudi M, Rezaeian M, Navaei-Nigjeh M, Katoli Z, Tayebi L.   +7 more
europepmc   +1 more source