Results 11 to 20 of about 28,578 (278)

Staphylococcus aureus SOS response: Activation, impact, and drug targets [PDF]

mLife
Staphylococcus aureus is a common cause of diverse infections, ranging from superficial to invasive, affecting both humans and animals. The widespread use of antibiotics in clinical treatments has led to the emergence of antibiotic‐resistant strains and ...
Kaiying Cheng, Yukang Sun, Huan Yu, Yingxuan Hu, Yini He, Yuanyuan Shen   +5 more
doaj   +2 more sources

Combined inactivation of the SOS response with TCA fumarases and the adaptive response enhances antibiotic susceptibility against Escherichia coli [PDF]

Frontiers in Microbiology
IntroductionTargeting bacterial DNA damage responses such as the SOS response represents a promising strategy for enhancing the efficacy of existing antimicrobials.
Marina Murillo-Torres, Marina Murillo-Torres, Isabel María Peñalver-Fernández, Marta Quero-Delgado, Sara Diaz-Diaz, María Romero-Muñoz, Esther Recacha, Esther Recacha, Esther Recacha, Fernando Docobo-Pérez, Fernando Docobo-Pérez, Fernando Docobo-Pérez, José Manuel Rodríguez-Martínez, José Manuel Rodríguez-Martínez, José Manuel Rodríguez-Martínez   +14 more
doaj   +2 more sources

Effect of a Defective Clamp Loader Complex of DNA Polymerase III on Growth and SOS Response in Pseudomonas aeruginosa. [PDF]

Microorganisms, 2022
Spinnato MC, Lo Sciuto A, Mercolino J, Lucidi M, Leoni L, Rampioni G, Visca P, Imperi F.   +7 more
europepmc   +3 more sources

Protein Transfer through an F Plasmid-Encoded Type IV Secretion System Suppresses the Mating-Induced SOS Response [PDF]

mBio, 2021
Bacterial type IV secretion systems (T4SSs) mediate the conjugative transfer of mobile genetic elements (MGEs) and their cargoes of antibiotic resistance and virulence genes.
Abu Amar M. Al Mamun, Kouhei Kishida, Peter J. Christie   +2 more
doaj   +2 more sources

Fluoroquinolone-specific resistance trajectories in E. coli and their dependence on the SOS-response [PDF]

BMC Microbiology
Background Fluoroquinolones are indispensable antibiotics used in treating bacterial infections in both human and veterinary medicine. However, resistance to these drugs presents a growing challenge.
Lisa Teichmann, Sam Luitwieler, Johan Bengtsson-Palme, Benno ter Kuile   +3 more
doaj   +2 more sources

Variability in intrinsic promoter strength underlies the temporal hierarchy of the Caulobacter SOS response induction [PDF]

Kamat A, Joseph AM, Rathour D, Badrinarayanan A.   +3 more
europepmc   +2 more sources

The SOS Response Activation and the Risk of Antibiotic Resistance Enhancement in Proteus spp. Strains Exposed to Subinhibitory Concentrations of Ciprofloxacin. [PDF]

Int J Mol Sci
Zabłotni A, Schmidt M, Siwińska M.
europepmc   +3 more sources

Exploring the links between SOS response, mutagenesis, and resistance during the recovery period. [PDF]

Antimicrob Agents Chemother
Ghosh S, Orman MA.
europepmc   +2 more sources

Zinc blocks SOS-induced antibiotic resistance via inhibition of RecA in Escherichia coli. [PDF]

PLoS ONE, 2017
Zinc inhibits the virulence of diarrheagenic E. coli by inducing the envelope stress response and inhibiting the SOS response. The SOS response is triggered by damage to bacterial DNA. In Shiga-toxigenic E.
Bryan E Bunnell, Jillian F Escobar, Kirsten L Bair, Mark D Sutton, John K Crane   +4 more
doaj   +1 more source

Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12. [PDF]

PLoS ONE, 2008
Repairing DNA damage begins with its detection and is often followed by elicitation of a cellular response. In E. coli, RecA polymerizes on ssDNA produced after DNA damage and induces the SOS Response.
Jarukit Edward Long, Nicholas Renzette, Richard C Centore, Steven J Sandler   +3 more
doaj   +1 more source