Analysis of the SOS response of
BMC Genomics, 2012 Background The SOS response is a well-known regulatory network present in most bacteria and aimed at addressing DNA damage. It has also been linked extensively to stress-induced mutagenesis, virulence and the emergence and dissemination of antibiotic ...
Sanchez-Alberola Neus +3 more
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Effect of the SOS response on the mean fitness of unicellular populations: a quasispecies approach. [PDF]
PLoS ONE, 2010 The goal of this paper is to develop a mathematical model that analyzes the selective advantage of the SOS response in unicellular organisms. To this end, this paper develops a quasispecies model that incorporates the SOS response.
Amit Kama, Emmanuel Tannenbaum
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Differential requirements of two recA mutants for constitutive SOS expression in Escherichia coli K-12. [PDF]
PLoS ONE, 2008 Repairing DNA damage begins with its detection and is often followed by elicitation of a cellular response. In E. coli, RecA polymerizes on ssDNA produced after DNA damage and induces the SOS Response.
Jarukit Edward Long +3 more
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Reconstitution of an SOS Response Pathway [PDF]
Cell, 1998 E. coli responds to DNA damage by derepressing the transcription of about 20 genes that make up the SOS pathway. Genetic analyses have shown that SOS induction in response to double-stranded DNA (dsDNA) breaks requires LexA repressor, and the RecA and RecBCD enzymes--proteins best known for their role as initiators of dsDNA break repair and homologous ...
Daniel G. Anderson +1 more
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Upstream of the SOS response: figure out the trigger [PDF]
Trends in Microbiology, 2006 The bacterial SOS regulon encodes a response to DNA damage that not only functions to relieve the incurred damage but also enhances adaptation through mutagenesis and the lateral spread of virulence factors. Recent papers have demonstrated that certain stimuli can indirectly generate the SOS-inducing signal by activation of endogenous DNA damage ...
Abram Aertsen, Chris W. Michiels
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Staphylococcus aureus SOS response: Activation, impact, and drug targets [PDF]
mLifeStaphylococcus aureus is a common cause of diverse infections, ranging from superficial to invasive, affecting both humans and animals. The widespread use of antibiotics in clinical treatments has led to the emergence of antibiotic‐resistant strains and ...
Kaiying Cheng +5 more
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Combined inactivation of the SOS response with TCA fumarases and the adaptive response enhances antibiotic susceptibility against Escherichia coli [PDF]
Frontiers in MicrobiologyIntroductionTargeting bacterial DNA damage responses such as the SOS response represents a promising strategy for enhancing the efficacy of existing antimicrobials.
Marina Murillo-Torres +14 more
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SOS System Induction Inhibits the Assembly of Chemoreceptor Signaling Clusters in Salmonella enterica. [PDF]
PLoS ONE, 2016 Swarming, a flagellar-driven multicellular form of motility, is associated with bacterial virulence and increased antibiotic resistance. In this work we demonstrate that activation of the SOS response reversibly inhibits swarming motility by preventing ...
Oihane Irazoki +3 more
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SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated [PDF]
Frontiers in MicrobiologyThe DNA damage inducible SOS response in bacteria serves to increase survival of the species at the cost of mutagenesis. The SOS response first initiates error-free repair followed by error-prone repair.
Olaug Elisabeth Torheim Bergum +12 more
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Stochastic Analysis of the SOS Response in Escherichia coli
PLoS ONE, 2009 DNA damage in Escherichia coli evokes a response mechanism called the SOS response. The genetic circuit of this mechanism includes the genes recA and lexA, which regulate each other via a mixed feedback loop involving transcriptional regulation and protein-protein interaction.
Yishai Shimoni +3 more
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