Inducible SOS Response System of DNA Repair and Mutagenesis in Escherichia coli [PDF]
International Journal of Biological Sciences, 2008 Chromosomal DNA is exposed to continuous damage and repair. Cells contain a number of proteins and specific DNA repair systems that help maintain its correct structure.
Celina Janion
doaj +5 more sources
Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response [PDF]
Frontiers in Microbiology, 2018 Many antibiotics, either directly or indirectly, cause DNA damage thereby activating the bacterial DNA damage (SOS) response. SOS activation results in expression of genes involved in DNA repair and mutagenesis, and the regulation of the SOS response ...
Trevor Selwood +12 more
doaj +2 more sources
Protein Transfer through an F Plasmid-Encoded Type IV Secretion System Suppresses the Mating-Induced SOS Response [PDF]
mBio, 2021 Bacterial type IV secretion systems (T4SSs) mediate the conjugative transfer of mobile genetic elements (MGEs) and their cargoes of antibiotic resistance and virulence genes.
Abu Amar M. Al Mamun +2 more
doaj +2 more sources
Fluoroquinolone-specific resistance trajectories in E. coli and their dependence on the SOS-response [PDF]
BMC MicrobiologyBackground Fluoroquinolones are indispensable antibiotics used in treating bacterial infections in both human and veterinary medicine. However, resistance to these drugs presents a growing challenge.
Lisa Teichmann +3 more
doaj +2 more sources
Computational analysis of LexA regulons in Cyanobacteria [PDF]
BMC Genomics, 2010 Background The transcription factor LexA plays an important role in the SOS response in Escherichia coli and many other bacterial species studied.
Su Zhengchang, Xu Minli, Li Shan
doaj +4 more sources
Zinc blocks SOS-induced antibiotic resistance via inhibition of RecA in Escherichia coli. [PDF]
PLoS ONE, 2017 Zinc inhibits the virulence of diarrheagenic E. coli by inducing the envelope stress response and inhibiting the SOS response. The SOS response is triggered by damage to bacterial DNA. In Shiga-toxigenic E.
Bryan E Bunnell +4 more
doaj +1 more source
The SOS Response of Biofilms [PDF]
International Journal of Clinical & Medical Microbiology, 2016 Background: Biofilms predominate in nearly all nutrient-sufficient ecosystems, both natural and clinical. In clinical settings, bacteria often encounter antimicrobial and DNA damaging agents. Factual evidence shows that more and more biofilm inducing antimicrobials trigger the SOS response of bacteria.
Katie Leiker, Tao Weitao
openaire +1 more source
Single-molecule imaging of LexA degradation in Escherichia coli elucidates regulatory mechanisms and heterogeneity of the SOS response. [PDF]
Nat Microbiol, 2021 The bacterial SOS response represents a paradigm of gene networks controlled by a master transcriptional regulator. Self-cleavage of the SOS repressor LexA induces a wide range of cell functions that are critical for survival and adaptation when bacteria
Jones EC, Uphoff S.
europepmc +3 more sources
The SOS response regulates adaptive mutation [PDF]
Proceedings of the National Academy of Sciences, 2000 Upon starvation some Escherichia coli cells undergo a transient, genome-wide hypermutation (called adaptive mutation) that is recombination-dependent and appears to be a response to a stressful environment. Adaptive mutation may reflect an inducible mechanism that generates genetic variability in times of stress ...
Peter L. Lee +5 more
openaire +3 more sources
Growth‐dependent heterogeneity in the DNA damage response in Escherichia coli
Molecular Systems Biology, 2022 In natural environments, bacteria are frequently exposed to sub‐lethal levels of DNA damage, which leads to the induction of a stress response (the SOS response in Escherichia coli).
Sebastián Jaramillo‐Riveri +5 more
doaj +1 more source