Results 31 to 40 of about 28,578 (278)

Systematically Altering Bacterial SOS Activity under Stress Reveals Therapeutic Strategies for Potentiating Antibiotics

mSphere, 2016
The bacterial SOS response is a DNA damage repair network that is strongly implicated in both survival and acquired drug resistance under antimicrobial stress.
Charlie Y. Mo, Sara A. Manning, Manuela Roggiani, Matthew J. Culyba, Amanda N. Samuels, Paul D. Sniegowski, Mark Goulian, Rahul M. Kohli   +7 more
doaj   +1 more source

Predrought and Its Persistence Determined the Phenological Changes of Stipa krylovii in Inner Mongolia

Agronomy, 2023
Clarifying the response of plant phenology to drought duration is helpful for accurately interpreting and predicting carbon sinks in ecosystems. Based on the response of different phenological periods of the dominant species Stipa krylovii to monthly ...
Erhua Liu, Guangsheng Zhou, Qijin He, Bingyi Wu, Xiaomin Lv   +4 more
doaj   +1 more source

Effect of the SOS response on the mean fitness of unicellular populations: a quasispecies approach. [PDF]

PLoS ONE, 2010
The goal of this paper is to develop a mathematical model that analyzes the selective advantage of the SOS response in unicellular organisms. To this end, this paper develops a quasispecies model that incorporates the SOS response.
Amit Kama, Emmanuel Tannenbaum
doaj   +1 more source

SOS-Inducing Drugs Trigger Nucleic Acid Release and Biofilm Formation in Gram-Negative Bacteria

Biomolecules
Our laboratory recently reported that induction of the SOS response, triggered by SOS-inducing drugs, was accompanied by a large release of DNA from enteric bacteria.
Peter Demjanenko, Sam Zheng, John K. Crane   +2 more
doaj   +1 more source

RecA and Specialized Error-Prone DNA Polymerases Are Not Required for Mutagenesis and Antibiotic Resistance Induced by Fluoroquinolones in Pseudomonas aeruginosa

Antibiotics, 2022
To cope with stressful conditions, including antibiotic exposure, bacteria activate the SOS response, a pathway that induces error-prone DNA repair and mutagenesis mechanisms.
Jessica Mercolino, Alessandra Lo Sciuto, Maria Concetta Spinnato, Giordano Rampioni, Francesco Imperi   +4 more
doaj   +1 more source

SOS genes are rapidly induced while translesion synthesis polymerase activity is temporally regulated

Frontiers in Microbiology
The DNA damage inducible SOS response in bacteria serves to increase survival of the species at the cost of mutagenesis. The SOS response first initiates error-free repair followed by error-prone repair.
Olaug Elisabeth Torheim Bergum, Amanda Holstad Singleton, Lisa Marie Røst, Antoine Bodein, Marie-Pier Scott-Boyer, Morten Beck Rye, Morten Beck Rye, Morten Beck Rye, Morten Beck Rye, Arnaud Droit, Per Bruheim, Marit Otterlei, Marit Otterlei   +12 more
doaj   +1 more source

Advancement of the 5-Amino-1-(Carbamoylmethyl)-1H-1,2,3-Triazole-4-Carboxamide Scaffold to Disarm the Bacterial SOS Response

Frontiers in Microbiology, 2018
Many antibiotics, either directly or indirectly, cause DNA damage thereby activating the bacterial DNA damage (SOS) response. SOS activation results in expression of genes involved in DNA repair and mutagenesis, and the regulation of the SOS response ...
Trevor Selwood, Trevor Selwood, Brian J. Larsen, Charlie Y. Mo, Charlie Y. Mo, Matthew J. Culyba, Matthew J. Culyba, Zachary M. Hostetler, Zachary M. Hostetler, Rahul M. Kohli, Rahul M. Kohli, Allen B. Reitz, Simon D. P. Baugh   +12 more
doaj   +1 more source

Role of RecA and the SOS response in thymineless death in Escherichia coli. [PDF]

PLoS Genetics, 2010
Thymineless death (TLD) is a classic and enigmatic phenomenon, documented in bacterial, yeast, and human cells, whereby cells lose viability rapidly when deprived of thymine.
Natalie C Fonville, David Bates, P J Hastings, Philip C Hanawalt, Susan M Rosenberg   +4 more
doaj   +1 more source

A qnr-plasmid allows aminoglycosides to induce SOS in Escherichia coli

eLife, 2022
The plasmid-mediated quinolone resistance (PMQR) genes have been shown to promote high-level bacterial resistance to fluoroquinolone antibiotics, potentially leading to clinical treatment failures.
Anamaria Babosan, David Skurnik, Anaëlle Muggeo, Gerald B Pier, Zeynep Baharoglu, Thomas Jové, Marie-Cécile Ploy, Sophie Griveau, Fethi Bedioui, Sébastien Vergnolle, Sophie Moussalih, Christophe de Champs, Didier Mazel, Thomas Guillard   +13 more
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source