Results 1 to 10 of about 23,689 (137)

SOST Inhibits Prostate Cancer Invasion. [PDF]

PLoS ONE, 2015
Inhibitors of Wnt signaling have been shown to be involved in prostate cancer (PC) metastasis; however the role of Sclerostin (Sost) has not yet been explored.
Bryan D Hudson, Nicholas R Hum, Cynthia B Thomas, Ayano Kohlgruber, Aimy Sebastian, Nicole M Collette, Matthew A Coleman, Blaine A Christiansen, Gabriela G Loots   +8 more
doaj   +15 more sources

Activation of sclerostin inhibits Isg20-Mediated aerobic glycolysis ameliorating renal Fibrosis: the renoprotective mechanism of hederagenin in CKD [PDF]

Redox Biology
Sclerostin (Sost) functions as an inhibitor of the Wnt/β-catenin signaling pathway, which is known to promote kidney cell epithelial-to-mesenchymal transition (EMT), and fibrosis in chronic kidney disease (CKD).
Rang-yue Han, Rui-zhi Tan, Ling-hui Xu, Jing-yi Lin, Tong Li, Hong-wei Su, Ping Li, Peng Liu, Hui-yao Lan, Li Wang   +9 more
doaj   +2 more sources

Role of SOST in Response to Mechanical Stimulation in Bone and Extraosseous Organs [PDF]

Biomolecules
Sclerostin (SOST) is a specific osteocyte protein. During the differentiation and proliferation of osteoblasts and osteoclasts, the high expression of SOST can inhibit bone formation and contribute to osteoporosis and the bone metastasis of malignant ...
Minyou Chen, Wenjing Li, Le Lei, Lingli Zhang   +3 more
doaj   +2 more sources

In silico design of novel precision vaccine targeting sclerostin epitopes for osteoporosis prevention and treatment [PDF]

Frontiers in Immunology
BackgroundOsteoporosis has become an increasingly pressing global public health challenge. Monoclonal antibody romosozumab (ROMO), which targets sclerostin (SOST), a critical inhibitor of bone formation, demonstrates considerable therapeutic efficacy ...
Jianzhou Luo, Tailin Wu, Tailin Wu, Bin Guan, Lin Li, Zili Yang, Huiren Tao   +6 more
doaj   +2 more sources

Novel Loss of Function Variant in SOST From Chinese Family Results in Sclerosteosis 1 [PDF]

Molecular Genetics & Genomic Medicine
Background SOST encodes a secreted glycoprotein that is similar in sequence to the differential screening‐selected gene aberrative in neuroblastoma (DAN) family of bone morphogenetic protein (BMP) antagonists.
Yufan Guo, Xintao Wu, Yuting Jin, Yu Gu, Yuting Lou, Pu Miao, Ye Wang, Bijun Zhang, Xueting Lin, Chudi Zhang, Jianhua Feng   +10 more
doaj   +2 more sources

Sclerostin Suppression Facilitates Uveal Melanoma Progression Through Activating Wnt/β-Catenin Signaling Via Binding to Membrane Receptors LRP5/LRP6

Frontiers in Oncology, 2022
ObjectiveUveal melanoma (UM) is the most frequent primary eye cancer in adults with a 50% mortality rate. Characterizing the fundamental signaling pathways that drive UM is of importance for the development of targeted therapy.
Hanqing Wang, Hanqing Wang, Sidi Zhao, Yang Liu, Fengyuan Sun, Fengyuan Sun, Xiaoming Huang, Xiaoming Huang, Tong Wu, Tong Wu   +9 more
doaj   +1 more source

HIF-1α inhibits Wnt signaling pathway by activating Sost expression in osteoblasts. [PDF]

PLoS ONE, 2013
The nature of the cellular and molecular mechanisms for the transition of avascular cartilage replacement with bone during endochondral ossification remains poorly understood. One of the driving forces is hypoxia.
Dafu Chen, Yang Li, Zhiyu Zhou, Chengai Wu, Yonggang Xing, Xuenong Zou, Wei Tian, Chi Zhang   +7 more
doaj   +1 more source

In vitro and in vivo Repair Effects of the NCF-Col-NHA Aerogel Scaffold Loaded With SOST Monoclonal Antibody and SDF-1 in Steroid-Induced Osteonecrosis

Frontiers in Bioengineering and Biotechnology, 2022
In the current study, we synthesized nanocellulose (NCF)-collagen (Col)-nano hydroxyapatite (NHA) organic-inorganic hybrid aerogels loaded with stromal cell derived factor-1 (SDF-1) and sclerostin monoclonal antibody (SOST McAb) and investigated their ...
Bing Xu, Bing Xu, Zeyu Luo, Duan Wang, Zeyu Huang, Zongke Zhou, Haoyang Wang   +6 more
doaj   +1 more source

Lipid Nanoparticle Delivery of siRNA to Osteocytes Leads to Effective Silencing of SOST and Inhibition of Sclerostin In Vivo

Molecular Therapy: Nucleic Acids, 2016
Sclerostin is a protein secreted by osteocytes that is encoded by the SOST gene; it decreases bone formation by reducing osteoblast differentiation through inhibition of the Wnt signaling pathway.
Genc Basha, Mina Ordobadi, Wilder R Scott, Andrew Cottle, Yan Liu, Haitang Wang, Pieter R Cullis   +6 more
doaj   +1 more source

SOST/Sclerostin Improves Posttraumatic Osteoarthritis and Inhibits MMP2/3 Expression After Injury. [PDF]

, 2018
Patients with anterior cruciate ligament (ACL) rupture are two times as likely to develop posttraumatic osteoarthritis (PTOA). Annually, there are ∼900,000 knee injuries in the United States, which account for ∼12% of all osteoarthritis (OA) cases.
Baek, Balemans, Baron, Bouaziz, Chan, Chang, Christiansen, Collette, Collette, Dejour, Glasson, Goldring, Hwang, Itin, Kapoor, Karlsson, Li, Li, Livak, Lockwood, Loeser, Lohmander, Loots, Mabey, Ovcharenko, Ratzlaff, Reppe, Rigoglou, Roudier, Sokolove, Swarnkar, Trapnell, Trapnell, Trapnell, van Dinther, Velasco, Wehmeyer, Zhu   +37 more
core   +2 more sources