Genetic evidence that SOST inhibits WNT signaling in the limb [PDF]
Developmental Biology, 1987 SOST is a negative regulator of bone formation, and mutations in human SOST are responsible for sclerosteosis. In addition to high bone mass, sclerosteosis patients occasionally display hand defects, suggesting that SOST may function embryonically.
Collette, Nicole M. +4 more
core +3 more sources
Macrophagic Sclerostin Loop2-ApoER2 Interaction Required by Sclerostin for Cardiovascular Protective Action. [PDF]
Adv Sci (Weinh)Sclerostin loop2‐ApoER2 interaction in macrophages is required by sclerostin to suppress NF‐κB nuclear translocation and phosphorylation, to promote macrophage conversion into anti‐inflammatory subtypes in atherosclerotic aortas, as well as to prevent atherosclerosis and aortic aneurysm development in ApoE−/− mice. Abstract Therapeutic antibody against
Wang L +27 more
europepmc +2 more sources
Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal models [PDF]
Metabolism, 2018 Sclerosteosis and van Buchem disease (VBD) are two rare autosomal recessive disorders that results from osteoblast hyperactivity, in which progressive bone overgrowth leads to very dense bones, distortion of the face, and entrapment of cranial nerves.
Aimy, Sebastian, Gabriela G, Loots
openaire +2 more sources
Targeting SOST using a small-molecule compound retards breast cancer bone metastasis
Molecular Cancer, 2022 Background Breast cancer metastasis to the bone can be exacerbated by osteoporosis, is associated with poor long-term survival, and has limited therapeutic options.
Lisha Sun +16 more
doaj +1 more source
Osteoprotegerin, sclerostin, and osteocalcin serum levels in thyroid disorder patients [PDF]
The Ukrainian Biochemical Journal, 2021 The maintenance of thyroid hormone homeostasis is essential in the regulation of skeletal system development, bone tissue mineralization and fracture risk prevention.
F. F. Rija, S. Z. Hussein, M. A. Abdalla
doaj +1 more source
How accurate is your sclerostin measurement?:Comparison between three commercially available sclerostin ELISA kits [PDF]
, 2016 Sclerostin, bone formation antagonist is in the spotlight as a potential biomarker for diseases presenting with associated bone disorders such as chronic kidney disease (CDK-MBD). Accurate measurement of sclerostin is therefore important.
Fisher, Emily +6 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2020 Steroid-induced osteonecrosis of femoral head (SONFH) is a common and serious complication caused by long-term and/or excessive use of glucocorticoids (GCs). The decreased activity and abnormal differentiation of bone marrow mesenchymal stem cells (BMSCs)
Lizhi Han +7 more
doaj +1 more source
Effect of sclerostin inactivation in a mouse model of severe dominant osteogenesis imperfecta
Scientific Reports, 2023 Osteogenesis imperfecta (OI) is a rare bone disease that is associated with fractures and low bone mass. Sclerostin inhibition is being evaluated as a potential approach to increase bone mass in OI.
Juliana Marulanda +4 more
doaj +1 more source
Differential involvement of Wnt signaling in Bmp regulation of cancellous versus periosteal bone growth [PDF]
, 2017 Bone morphogenetic proteins (Bmp) are well-known to induce bone formation following chondrogenesis, but the direct role of Bmp signaling in the osteoblast lineage is not completely understood.
Bellido, Teresita +5 more
core +3 more sources
Osteocytes and mechanical loading: The Wnt connection [PDF]
, 2019 Bone adapts to the mechanical forces that it experiences. Orthodontic tooth movement harnesses the cell‐ and tissue‐level properties of mechanotransduction to achieve alignment and reorganization of the dentition.
Ahn Y +21 more
core +1 more source