Results 21 to 30 of about 23,758 (203)
Frontiers in Bioengineering and Biotechnology, 2019 Sclerostin (Sost) and dickkopf (Dkk)-1 are inhibitors of the Wnt signaling pathway that plays a role in regenerative processes. Hypoxia-based strategies are used for regenerative approaches, but the influence of hypoxia on Sost and Dkk-1 production in a ...
Klara Janjić +8 more
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Bioengineering, 2022 Bone is a dynamic organ that can adapt its structure to meet the demands of its biochemical and biophysical environment. Osteocytes form a sensory network throughout the tissue and orchestrate tissue adaptation via the release of soluble factors such as ...
Robert T. Brady +2 more
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Tight Sum-of-Squares lower bounds for binary polynomial optimization problems [PDF]
, 2016 We give two results concerning the power of the Sum-of-Squares(SoS)/Lasserre hierarchy. For binary polynomial optimization problems of degree $2d$ and an odd number of variables $n$, we prove that $\frac{n+2d-1}{2}$ levels of the SoS/Lasserre hierarchy ...
Kurpisz, Adam +2 more
core +2 more sources
, 2022 Supplemental Figures 1-4 Table 1 - Primers Table 2- Echo ...
Merryman, William, Joll, J. Ethan
openaire +1 more source
PLoS ONE, 2017 Connexin43 (Cx43) is the main gap junction protein expressed in bone forming cells, where it modulates peak bone mass acquisition and cortical modeling.
Susan K Grimston +3 more
doaj +1 more source
Iron-enriched diet contributes to early onset of osteoporotic phenotype in a mouse model of hereditary hemochromatosis [PDF]
, 2018 Osteoporosis is associated with chronic iron overload secondary to hereditary hemochromatosis (HH), but the causative mechanisms are incompletely understood.
Camacho, António +7 more
core +4 more sources
Sclerostin inhibition alleviates breast cancer-induced bone metastases and muscle weakness [PDF]
, 2019 Breast cancer bone metastases often cause a debilitating non-curable condition with osteolytic lesions, muscle weakness and a high mortality. Current treatment comprises chemotherapy, irradiation, surgery and anti-resorptive drugs that restrict but do ...
Brandt, Diana +5 more
core +1 more source
Cellular Physiology and Biochemistry, 2018 Background/Aims: Postmenopausal osteoporosis is considered to be an autoimmune and inflammatory process, and IL-17 plays important roles in the loss of bone mass.
Li You +4 more
doaj +1 more source
lncRNA MEG3 Suppresses the Progression of Ankylosis Spondylitis by Regulating the Let-7i/SOST Axis
Frontiers in Molecular Biosciences, 2020 Ankylosis spondylitis (AS) is a disease mainly characterized by sacroiliac joint and spinal attachment point inflammation. Long non-coding RNA (lncRNA) plays a key role in the progression of many diseases.
Junjie Ma +3 more
doaj +1 more source
All-trans Retinoic Acid and Beta-Carotene Increase Sclerostin Production in C2C12 Myotubes
Biomedicines, 2023 Sclerostin is a protein secreted by osteocytes whose encoding gene SOST is regulated by mechanical stimuli, cytokines, and all-trans retinoic acid (ATRA) and mediates antianabolic effects on bone formation as an inhibitor of the canonical Wnt/β-catenin ...
Franz Ewendt +3 more
doaj +1 more source