Results 31 to 40 of about 23,758 (203)

Investigation of the Underlying Mechanism of Sclerosteosis Expression in Muscle Tissue in Multiple Myeloma with Sarcopenia

Journal of Inflammation Research, 2023
Jie Ren,1,* Jingzhou Wang,2,* Xingchen Yao,1 Yue Wu,1 Ming Shi,1 Xiangjun Shi,3 Xinru Du1 1Department of Orthopaedics, Beijing Chao-yang Hospital, Beijing, 100020, People’s Republic of China; 2Department of Orthopaedics, Beijing Daxing District ...
Ren J, Wang J, Yao X, Wu Y, Shi M, Shi X, Du X   +6 more
doaj  

The Pacific Island Volcanology and Its Relation to the Groundwater Features Through Magmatic Signatures [PDF]

Sustainable Earth Trends
The Pacific Plate is one of the heaviest tectonic plates, hosting multiple Pacific Island countries. Geological research has long provided evidence of volcanic magmatic events, which have frequently caused subsurface activities.
Ronald Maharaj, Azekah Swamy, Shailesh Kumar Singh, Sandeep Panchal   +3 more
doaj   +1 more source

Cortical bone adaptation to a moderate level of mechanical loading in male Sost deficient mice

Scientific Reports, 2020
Loss-of-function mutations in the Sost gene lead to high bone mass phenotypes. Pharmacological inhibition of Sost/sclerostin provides a new drug strategy for treating osteoporosis.
Haisheng Yang, Alexander Büttner, Laia Albiol, Catherine Julien, Tobias Thiele, Christine Figge, Ina Kramer, Michaela Kneissel, Georg N. Duda, Sara Checa, Bettina M. Willie   +10 more
doaj   +1 more source

Increase in Dickkopf-1 Serum Level in Recent Spondyloarthritis. Data from the DESIR Cohort. [PDF]

PLoS ONE, 2015
To investigate DKK-1 and SOST serum levels among patients with recent inflammatory back pain (IBP) fulfilling ASAS criteria for SpA and associated factors.The DESIR cohort is a prospective, multicenter French cohort of 708 patients with early IBP ...
Gaetane Nocturne, Stephan Pavy, Saida Boudaoud, Raphaèle Seror, Philippe Goupille, Philippe Chanson, Désirée van der Heijde, Floris van Gaalen, Francis Berenbaum, Xavier Mariette, Karine Briot, Antoine Feydy, Pascal Claudepierre, Philippe Dieudé, Joanne Nithitham, Kimberly E Taylor, Lindsey A Criswell, Maxime Dougados, Christian Roux, Corinne Miceli-Richard   +19 more
doaj   +1 more source

Co-expression of DKK-1 and Sclerostin in Subchondral Bone of the Proximal Femoral Heads from Osteoarthritic Hips [PDF]

, 2017
Osteoarthritis (OA) is a progressively degenerative joint disease influenced by structural and metabolic factors. There is growing evidence that subchondral bone is involved in both symptomatic and structural progression in OA.
Afsie Sabokbar, Allahdad Zarei, M. Kassim Javaid, Philippa A. Hulley   +3 more
core   +2 more sources

Transcriptional control of Sost in bone

Bone, 2017
Sclerostin is an osteocyte derived negative regulator of bone formation. A highly specific expression pattern and the exclusive bone phenotype have made Sclerostin an attractive target for therapeutic intervention in treating metabolic bone diseases such as osteoporosis and in facilitating fracture repair.
Sebastian, Aimy, Loots, Gabriela G.
openaire   +2 more sources

Does Telemedical Support of First Responders Improve Guideline Adherence in an Offshore Emergency Scenario? A Simulator-Based Prospective Study [PDF]

, 2019
OBJECTIVE: To investigate, in a simulator-based prospective study, whether telemedical support improves quality of emergency first response (performance) by medical non-professionals to being non-inferior to medical professionals.
Landgraf, Philipp, Lawatscheck, Robert, Luz, Maria, Schröder, Torsten, Spies, Claudia, Wernecke, Klaus-Dieter   +5 more
core   +1 more source

Expression of Sclerostin in Osteoporotic Fracture Patients Is Associated with DNA Methylation in the CpG Island of the SOST Gene

International Journal of Genomics, 2019
Purpose. SOST gene is one of the key factors in regulating bone absorption. Although there are reports showing diverse transcription factors, epigenetic modification could be responsible for regulating SOST gene expression.
Yanming Cao, Bin Wang, Ding Wang, Dongxiang Zhan, Caiyuan Mai, Peng Wang, Qiushi Wei, Yamei Liu, Haibin Wang, Wei He, Liangliang Xu   +10 more
doaj   +1 more source

EFFECT OF PKP ON SERUM SOST IN PATIENTS WITH VERTEaBRAL COMPRESSION FRACTURES [PDF]

Acta Ortopédica Brasileira
Objective: This study sought to determine serum sclerostin (SOST) expression in patients with osteoporotic thoracolumbar vertebral compression fractures before and after percutaneous kyphoplasty (PKP). Methods: Serum SOST levels were quantified with a
ENZHI WANG, JIANJUN LIN, GUANGWEI XU, XINHUA WANG, MIFANG CHEN   +4 more
doaj   +2 more sources

Impacto funcional de polimorfismos del gen de la esclerostina sobre la metilación de ADN y la expresión génica

Revista de Osteoporosis y Metabolismo Mineral, 2020
Introducción: Varios estudios de barrido genómico (GWAS) y otros focalizados en el gen de la esclerostina (SOST) han encontrado que algunos polimorfismos de SOST se asocian con la masa ósea y el riesgo de fracturas.
Del Real A, Sañudo C, García-Ibarbia C, Santurtún A, Zarrabeitia MT, Pérez-Núñez MI, Laguna E, López-Delgado L, Fernández AF, Fraga MF, Riancho JA   +10 more
doaj   +1 more source