Results 41 to 50 of about 23,758 (203)

Conditional Deletion of Sost in MSC‐derived lineages Identifies Specific Cell Type Contributions to Bone Mass and B Cell Development [PDF]

, 2018
Sclerostin (Sost) is a negative regulator of bone formation and blocking its function via antibodies has shown great therapeutic promise by increasing both bone mass in humans and animal models.
Bajwa, Jamila, Chang, Jiun C., Economides, Aris E., Horan, Daniel J., Hum, Nicholas R., Loots, Gabriela G., Manilay, Jennifer O., Mendez, Melanie E., Murugesh, Deepa K., Robling, Alexander G., Yee, Cristal S.   +10 more
core   +2 more sources

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing [PDF]

, 2015
PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalacia ...
Carriero, A, Chang, Y M, Farquharson, C, Houston, D A, Javaheri, B, Kazeruni, B N, Millan, J L, Oldknow, K J, Pitsillides, A A, Salmon, P, Shefelbine, S, Staines, K A   +11 more
core   +4 more sources

Coronectomy of deeply impacted lower third molar : incidence of outcomes and complications after one year follow-up [PDF]

, 2015
Objectives: The purpose of present study was to assess the surgical management of impacted third molar with proximity to the inferior alveolar nerve and complications associated with coronectomy in a series of patients undergoing third molar surgery ...
Ajbage, Jimoh Olubanwo, Heijsters, Guido, Politis, Constantinus, Salem, Ahmed Sobhy, Schepers, Serge, Van Slycke, Sarah, Vrielinck, Luc   +6 more
core   +3 more sources

A Novel Mutation in SOST Gene Causes Sclerosteosis

Journal of the Endocrine Society, 2021
Abstract Background: Sclerostin is a SOST gene product that inhibits osteoblasts activity and prevents excessive bone formation by antagonizing Wnt signaling pathway. Sclerosteosis has been linked to the loss of function mutation in SOST gene.
Alyusuf, Ebtihal Y, Ekhzaimy, Aishah A, Alzahrani, Ali   +2 more
openaire   +1 more source

Do hypoxia and L-mimosine modulate sclerostin and dickkopf-1 production in human dental pulp-derived cells? Insights from monolayer, spheroid and tooth slice cultures

BMC Oral Health, 2018
Background To understand the responses of the dental pulp to hypoxia is of high relevance for regenerative endodontics and dental traumatology. Here, we aimed to reveal the effects of hypoxia and the hypoxia mimetic agent L-mimosine (L-MIM) on the ...
Klara Janjić, Barbara Cvikl, Christoph Kurzmann, Andreas Moritz, Hermann Agis   +4 more
doaj   +1 more source

Bone Organoids: A Novel Tool for Modeling and Managing Skeletal Disorders in Diabetes

Advanced Science, EarlyView.
This review synthesizes advances in bone organoid engineering and evaluates their potential to model diabetic bone fragility. Current in vitro and animal models do not fully recapitulate diabetes‐associated skeletal phenotypes. Cell‐based and scaffold‐based bone organoids are discussed as complementary approaches to reconstruct multicellular bone ...
Shuangzhe Lin, Karthikeyan Narayanan, Deepak Vashishth   +2 more
wiley   +1 more source

Myocyte enhancer factor 2C: an osteoblast transcription factor identified by DMSO enhanced mineralization [PDF]

, 2011
Free to read on publisher website Rapid mineralization of cultured osteoblasts could be a useful characteristic in stem-cell mediated therapies for fracture and other orthopaedic problems. Dimethyl sulfoxide (DMSO) is a small amphipathic solvent molecule
Bacic-Welsh, Desa, Hobbs, Carl, Hutmacher, Dietmar, Morrison, Nigel, Stephens, Alexandre, Stephens, Sebastien, Woodruff, Mia   +6 more
core   +2 more sources

Peptide Receptor‐Functionalized AuNP‐Embedded Zwitterionic Biopolymeric Nanohydrogel for Electrochemical Sclerostin Sensing

Advanced Science, EarlyView.
We report an electrochemical biosensor that employs biopanning‐derived affinity peptides as selective receptors on a multifunctional chitosan–zwitterionic–gold nanoparticle (CS–ZI–AuNPs) nanohydrogel interface. The CS–ZI–AuNPs nanohydrogel exhibits antifouling properties, abundant sites for stable peptide immobilization, and efficient electrochemical ...
Hyo Jeong Yang, Jae Hwan Shin, Mingi Jo, Changyeon Lee, Hyunmin Yi, Al‐Montaser Bellah H. Ali, Jong Pil Park   +6 more
wiley   +1 more source

A Novel Mutation in a Gene Causes Sclerosteosis in a Family of Mediterranean Origin

Medicina, 2022
Background and Objectives: Sclerostin is an SOST gene product that inhibits osteoblast activity and prevents excessive bone formation by antagonizing the Wnt signaling pathway. Sclerosteosis has been linked to loss of function mutations in the SOST gene.
Aishah A. Ekhzaimy, Ebtihal Y. Alyusuf, Meshael Alswailem, Ali S. Alzahrani   +3 more
doaj   +1 more source

On Three Generalizations of Contraction

, 2014
We introduce three forms of generalized contraction (GC). Roughly speaking, these are motivated by allowing contraction to take place after small transients in time and/or amplitude.
Margaliot, Michael, Sontag, Eduardo D., Tuller, Tamir   +2 more
core   +1 more source