Results 61 to 70 of about 23,758 (203)

Cbfa1/RUNX2 Directs Specific Expression of the Sclerosteosis Gene (SOST) [PDF]

Journal of Biological Chemistry, 2004
Loss-of-function mutations in the sclerosteosis gene (SOST) cause a rare sclerosing bone dysplasia characterized by skeletal overgrowth. Cbfa1/RUNX2 is a key transcriptional regulator of osteoblast function. Here we link these two pathways by demonstrating, via gel shift and transient transfection analyses, that Cbfa1 binding to the proximal SOST ...
Brad, Sevetson, Scott, Taylor, Yang, Pan
openaire   +2 more sources

The Role of Wnt Signaling in Age‐Related Alveolar Bone Loss and Regeneration

Journal of Periodontal Research, EarlyView.
The graphical abstract summarizes key signaling pathways involved in bone formation and resorption associated with Wnt signaling across young and aged long bone and jaw tissues. Levels of evidence are indicated as robust, moderate, or emerging, reflecting the current experimental support in each context.
Hsiao H. Sung, Navya Chalamalasetty, Ali Alzainal, Hanlong Liu, Lexuan Wang, Pietra Colacrai Arikita, Ivy C. X. Wei, Hom‐Lay Wang, M. H. J. van den Bosch, Michelle S. Caird, Peter M. van der Kraan, Kenneth M. Kozloff, Esmeralda Blaney Davidson   +12 more
wiley   +1 more source

Evaluating the correlation of sclerostin levels with obesity and type 2 diabetes in a multiethnic population living in Kuwait

Frontiers in Endocrinology
Obesity and Type 2 Diabetes Mellitus (T2DM) are intricate metabolic disorders with a multifactorial etiology, often leading to a spectrum of complications.
Tahani Alramah, Preethi Cherian, Irina Al-Khairi, Mohamed Abu-Farha, Mohamed Abu-Farha, Thangavel Alphonse Thanaraj, Ahmed N. Albatineh, Fayez Safadi, Fayez Safadi, Hamad Ali, Muhammad Abdul-Ghani, Muhammad Abdul-Ghani, Jaakko Tuomilehto, Jaakko Tuomilehto, Jaakko Tuomilehto, Heikki A. Koistinen, Heikki A. Koistinen, Heikki A. Koistinen, Fahd Al-Mulla, Fahd Al-Mulla, Jehad Abubaker   +20 more
doaj   +1 more source

Sum-of-squares hierarchy lower bounds for symmetric formulations

, 2016
We introduce a method for proving Sum-of-Squares (SoS)/ Lasserre hierarchy lower bounds when the initial problem formulation exhibits a high degree of symmetry.
Kurpisz, Adam, Leppänen, Samuli, Mastrolilli, Monaldo   +2 more
core   +1 more source

Resorption controls bone anabolism driven by PTH receptor signaling in osteocytes [PDF]

, 2013
The contribution of remodeling-based bone formation coupled to osteoclast activity versus modeling-based bone formation that occurs independently of resorption, to the anabolic effect of PTH remains unclear.
Allen, Matthew R., Bellido, Teresita, Condon, Keith W., Lee, Eun-Young, Lezcano, Virginia, Plotkin, Lilian I., Rhee, Yumie, Ronda, Ana C.   +7 more
core   +1 more source

Building bone with a SOST-PTH partnership [PDF]

Journal of Bone and Mineral Research, 2010
The discovery of the SOST gene, whose protein product, sclerostin, is an osteocyte-derived inhibitor of Wnt signalling and bone formation, has provided a major advance in bone biology. It gives us new insights into the communicating networks among bone cells and, importantly, to new ways of restoring bone once it has been lost.
openaire   +2 more sources

TIEG and estrogen modulate SOST expression in the murine skeleton [PDF]

Journal of Cellular Physiology, 2017
TIEG knockout (KO) mice exhibit a female‐specific osteopenic phenotype and altered expression of TIEG in humans is associated with osteoporosis. Gene expression profiling studies identified sclerostin as one of the most highly up‐regulated transcripts in the long bones of TIEG KO mice relative to WT littermates suggesting that TIEG may regulate SOST ...
Malayannan Subramaniam, Kevin S. Pitel, Elizabeth S. Bruinsma, David G. Monroe, John R. Hawse   +4 more
openaire   +2 more sources

Long‐term stability of conventional non‐regenerative periodontal treatment for furcation defects

Periodontology 2000, EarlyView.
Abstract Background Furcation involvement (FI) in multi‐rooted teeth poses significant challenges in periodontal therapy due to complex anatomy and difficulty in achieving effective maintenance. FI is associated with increased periodontal destruction, especially in sites with narrow furcation entrances and deep root concavities.
Guo‐Hao Lin, April Martinez, Vincent Li, Eric Lee, Kang‐Wei Tu, Richard Kao, Hom‐Lay Wang   +6 more
wiley   +1 more source

WNT-5a and SOST Levels in Gingival Crevicular Fluid Depend on the Inflammatory and Osteoclastogenic Activities of Periodontal Tissues

Medicina, 2021
Background and Objectives: Wnt signaling leads to stimulation of osteoblasts and it reduces osteoclastogenesis and bone resorption via the regulation of the osteprotegrin and receptor activator of nuclear factor kappa-Β ligan (RANKL).
Georgios S. Chatzopoulos, Massimo Costalonga, Kim C. Mansky, Larry F. Wolff   +3 more
doaj   +1 more source

How accurate is your sclerostin measurement? Comparison between two commercially available sclerostin ELISA kits. [PDF]

, 2014
Introduction: Sclerostin (SOST), osteocyte-secreted soluble antagonist of the Wnt/β-catenin signaling pathway, is a potent inhibitor of osteoblastogenesis.
Fraser, William, Piec, Isabelle, Tang, Jonathan, Washbourne, Christopher   +3 more
core