Results 91 to 100 of about 66,099 (245)
Advanced Science, EarlyView.This study identifies a novel mechanism of nasopharyngeal carcinoma (NPC) cisplatin chemoresistance that DDAH1 expression is associated with cisplatin resistance in NPC cells primarily through the enhancement of the phosphoinositide Janus kinase 2 (JAK2)‐signal transducer and activator of transcription 3 (STAT3) pathway.
Jin‐Hao Yang +10 more
wiley +1 more source
Oct-3/4 and Sox2 Regulate Oct-3/4 Gene in Embryonic Stem Cells [PDF]
, 2004 Sayaka Okumura-Nakanishi +3 more
openalex +1 more source
EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways
Advanced Science, EarlyView.EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen +12 more
wiley +1 more source
Transcriptional Regulation of Nanog by OCT4 and SOX2 [PDF]
, 2005 David J. Rodda +6 more
openalex +1 more source
Advanced Science, EarlyView.PCSK9 acts as a molecular chaperone promoting LIN28A lysosomal degradation. LIN28A elevates transcription factor HES5, increasing JMY expression. PCSK9 loss causes neural tube defects (NTDs) by disrupting the LIN28A/HES5/JMY axis, and high JMY disorganizes the neural progenitor cell microfilament network, leading to incomplete neural tube structure in ...
Xiaoshuai Li +6 more
wiley +1 more source
Advanced Science, EarlyView.Engineered macrophage‐derived exosomes overexpressing GNA12 and GNA13 reprogram glial cells to promote neuroprotection and neural regeneration following SCI. A chitosan‐based thermosensitive hydrogel enables sustained intranasal exosome delivery, bypassing systemic barriers and enhancing therapeutic efficacy.
Yangyang Wang +13 more
wiley +1 more source
Hypermethylation of SOX2 Promoter in Endometrial Carcinogenesis
Obstetrics and Gynecology International, 2010 This paper aimed at investigating the expression and methylation profiles of SOX2, a gene coding for the stem cell-related transcription factor SOX2, in endometrial carcinomas.
Oscar Gee-Wan Wong +6 more
doaj +1 more source
Differential Roles for Sox15 and Sox2 in Transcriptional Control in Mouse Embryonic Stem Cells [PDF]
, 2005 Masayoshi Maruyama +3 more
openalex +1 more source
Advanced Science, EarlyView.Large‐scale generation of disc‐shaped models mimicking human epiblast layer is achieved by bioprinting of human pluripotent stem cells using a well‐defined biomatrix. The bioactive component and physical confinement from laminin/alginate microgels, combined with the endogenous regulation of the WNT signaling pathway regulated disc‐like morphogenesis ...
Yixue Luo +11 more
wiley +1 more source