Results 101 to 110 of about 66,099 (245)

Targeting AKT as a promising strategy for SOX2-positive, chemoresistant osteosarcoma

Bone Research
Osteosarcoma (OS) is the most prevalent type of primary malignant bone cancer and currently lacks effective targeted treatments. Increasing evidence indicates that SOX2 overexpression is a primary driver of OS.
Yujie Liu, Li Kang, Jing Luo, Minglei Yang, Da Wang, Juelan Ye, Xinghai Yang, Wei Wan, Jiemin Wong, Jianru Xiao   +9 more
doaj   +1 more source

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

Advanced Science, EarlyView.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo, Youngjun Kim, Rian Kang, Seho Lee, Dang Du Nguyen, Soomin Park, Dongjoon Lee, Jong Won Han, Inhee Mook‐Jung, Luke P. Lee, Jong‐Chan Park, Inki Kim   +11 more
wiley   +1 more source

WTAP Mediated m6A Modification Stabilizes PDIA3P1 and Promotes Tumor Progression Driven by Histone Lactylation in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a new mechanism by which PDIA3P1 regulates the progression of esophageal squamous cell carcinoma (ESCC). PDIA3P1 upregulates the expression of GLUT1 and HK2, promoting glycolysis and lactate production. Lactate upregulates the lactylation level of histone H4K8 and activates the transcription of target gene BMP7, ultimately ...
Tao Huang, Qi You, Jiawei Liu, Xuguang Shen, Dengjun Huang, Xinlu Tao, Zhijie He, Chengwei Wu, Xinran Xi, Shouqiang Yu, Feng Liu, Zhihao Wu, Wenjun Mao, Shaojin Zhu   +13 more
wiley   +1 more source

Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea [PDF]

, 2008
Alain Dabdoub, Chandrakala Puligilla, Jennifer M. Jones, Bernd Fritzsch, Kathryn S.E. Cheah, Larysa Pevny, Matthew W. Kelley   +6 more
openalex   +3 more sources

Regulation of the Pluripotency Marker Rex-1 by Nanog and Sox2 [PDF]

, 2006
Wenjing Shi, Hui Wang, Guangjin Pan, Yijie Geng, Yunqian Guo, Duanqing Pei   +5 more
openalex   +1 more source

Anthocyanins Prevent Mastitis Exacerbation by Inhibiting PANoptosis Activation

Advanced Science, EarlyView.
PANoptosis activation is an effective therapeutic target during mastitis progression, and Gasdermin D activation is key factor contributing to blood milk barrier damage during mastitis, while cyanidin 3‐O‐galactoside can inhibit these targets to exert a protective effect. Therefore, the extraction of key active ingredients from plants for the treatment
Rui Feng, Lin Guo, Fan Wang, Qian Zhang, Guoyan Wang, Hefei Huang, Wei Du, Hong An, Yue Yang, Henghui Miao, Peng Zheng, Tingting Chu, Dengke Zhang, Xiaoxue Yan, Xiaoyu Mi, Qian Ma, Weilin Gao, Yushan Li, Song Li, Yong Zhang, Zhenliang Zhu, Yu Wang, Jun Liu, Xu Liu   +23 more
wiley   +1 more source

Oct4 and Sox2 Directly Regulate Expression of Another Pluripotency Transcription Factor, Zfp206, in Embryonic Stem Cells [PDF]

, 2007
Zheng-Xu Wang, Christina Hui-Leng Teh, Jacqueline L.L. Kueh, Thomas Lufkin, Paul Robson, Lawrence W. Stanton   +5 more
openalex   +1 more source

LncRNA TMEM99 Complexes with IGF2BP2 to Inhibit Autophagy in Lung Adenocarcinoma

Advanced Science, EarlyView.
LncRNA TMEM99 is significantly upregulated in lung adenocarcinoma (LUAD) and correlates with poor prognosis. It promotes LUAD cell proliferation, migration, and invasion while suppressing autophagy. Mechanistically, TMEM99 binds FUBP3 and recruits IGF2BP2 in an m⁶A‐dependent manner to stabilize and enhance p21 mRNA translation, uncovering a novel ...
Zhigang Wu, Yue Zhao, Yizhou Peng, Pengcheng Liu, Qixuan Huang, Yang Wo, Yunjian Pan, DongDong Zheng, Chongze Yuan, Yan Shang, Xiao Chen, Hui Hong, Yihua Sun   +12 more
wiley   +1 more source

Sox2 and Jagged1 Expression in Normal and Drug-Damaged Adult Mouse Inner Ear [PDF]

, 2007
Elizabeth C. Oesterle, Sean Campbell, Ruth Taylor, Andrew Forge, Clifford R. Hume   +4 more
openalex   +1 more source

Decoy Extracellular Vesicles Overcome Triple‐Negative Breast Cancer Heterogeneity via Membrane‐Cytoplasm‐Mitochondria Cascade Targeting

Advanced Science, EarlyView.
siT/MOF@EVs overcome TNBC heterogeneity through a tumor cell membrane–cytoplasm–mitochondria cascade effect, triggering a self‐reinforcing anti‐tumor immune cycle and durable immune memory. The system enables sequential targeting of membrane checkpoints ligands (decoy effect), cytoplasmic siRNA delivery (CSC suppression), and mitochondrial MOF ...
Chuanrong Chen, Ming Shen, Xiaofeng Wan, Lili Sheng, Na Hao, Man Li, Menglin Xu, Yang He, Jiali Zhang   +8 more
wiley   +1 more source