Results 101 to 110 of about 70,586 (295)
Coordination of EZH2 and SOX2 specifies human neural fate decision [PDF]
, 2021 Yuan Zhao +11 more
openalex +1 more source
Advanced Science, EarlyView.Human islet amyloid polypeptide (hIAPP) was used to mimic T2DM, and Aβ42‐hIAPP co‐oligomers were delivered into the human mature cerebral organoids (COs), which reproduce typical AD pathology and significant neuronal death more closely resembling that of AD patients.
Jin Yan +6 more
wiley +1 more source
Advanced Science, EarlyView.Acquired sensorineural hearing loss is primarily caused by the damage or loss of cochlear hair cells, induced by factors such as noise exposure and ototoxic drugs. The deficiency of apoptosis‐inducing gene Cidea in Cidea KO mice or by delivering CRISPR/SlugCas9‐HF via AAV to edit Cidea effectively alleviated hair cell damage and hearing loss caused by ...
Shasha Zhang +14 more
wiley +1 more source
KRAS-driven pancreatic ductal adenocarcinoma cell lines harbour putative cancer stem cells
OncologiePancreatic cancer stem cells (CSCs) are known culprits of recurrent pancreatic ductal adenocarcinoma (PDAC). The disputable presence of CSCs in continuous cell lines has led to an extensive application of patient-derived CSC culture for experimentation ...
Teh Yuan Han +5 more
doaj +1 more source
Clinical diagnosis of presumed SOX2 gonadosomatic mosaicism
, 2021 Malena Daich Varela +9 more
openalex +1 more source
Reciprocal regulation of LINC00941 and SOX2 promotes progression of esophageal squamous cell carcinoma [PDF]
, 2023 Juntao Lu +6 more
openalex +1 more source
Advanced Science, EarlyView.In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen +15 more
wiley +1 more source
Open MedicineImmature ovarian teratomas are rare malignant germ cell tumours with variable neuroepithelial differentiation and limited prognostic markers. Their grading is subjective and challenging, with heterogeneous clinical behaviour and limited therapeutic ...
Tavdgiridze Nino +4 more
doaj +1 more source
Engineering Immune Cell to Counteract Aging and Aging‐Associated Diseases
Advanced Science, EarlyView.This review highlights a paradigm shift in which advanced immune cell therapies, initially developed for cancer, are now being harnessed to combat aging. By engineering immune cells to selectively clear senescent cells and remodel pro‐inflammatory tissue microenvironments, these strategies offer a novel and powerful approach to delay age‐related ...
Jianhua Guo +5 more
wiley +1 more source
STING deficiency promotes motor recovery in mice following brachial plexus root avulsion
Animal Models and Experimental Medicine, EarlyView.STING deficiency can increase the body weight, promote motor recovery, decrease MN death, inhibit pyroptosis and neuroinflammation, increase remyelination, and reduce the atrophy of the biceps brachii in mice with BPRA. Abstract Background Brachial plexus root avulsion (BPRA), a well‐known form of peripheral nerve injury, results in motor function loss
Yu Peng +4 more
wiley +1 more source