Results 41 to 50 of about 36,214 (254)

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Soy Food Consumption and Breast Cancer Prognosis [PDF]

Cancer Epidemiology, Biomarkers & Prevention, 2011
Abstract Background: Contrary to earlier clinical studies suggesting that soy may promote breast tumor growth, two recent studies show that soy-containing foods are not adversely related to breast cancer prognosis. We examined, using data from the Women's Healthy Eating and Living (WHEL) study, the effect of soy intake on breast cancer ...
Bette J, Caan, Loki, Natarajan, Barbara, Parker, Ellen B, Gold, Cynthia, Thomson, Vicky, Newman, Cheryl L, Rock, Minya, Pu, Wael, Al-Delaimy, John P, Pierce   +9 more
openaire   +2 more sources

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Bioavailability of isoflavones from soy products in equol producers and non-producers in Japanese women

Journal of Nutrition & Intermediary Metabolism, 2016
Background: The estimated intake of soy isoflavones from a meal has been based on the content in a food, but the health effects of soy isoflavones are possibly affected by their bioavailability.
Ayako Miura, Chitose Sugiyama, Hiroyuki Sakakibara, Kayoko Simoi, Toshinao Goda   +4 more
doaj   +1 more source

Integrated Metabolomics and Volatolomics for Comparative Evaluation of Fermented Soy Products

Foods, 2021
Though varying metabolomes are believed to influence distinctive characteristics of different soy foods, an in-depth, comprehensive analysis of both soluble and volatile metabolites is largely unreported. The metabolite profiles of different soy products,
Sang-Hee Lee, Sunmin Lee, Seung-Hwa Lee, Hae-Jin Kim, Digar Singh, Choong-Hwan Lee   +5 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

SOY-DERIVED MICROBIAL METABOLITE EQUOL IN CANCER PREVENTION

Agricultura, 2017
The human diet is integral part of overall health, and human response to foods and their components is often dependent on their dynamic interrelationship with microbes residing in the oral and gastrointestinal tract.
Liliana Mureșan, T. Rusu, T. Y. Wang, J. B. Park, Doina Clapa   +4 more
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Cumulative Meta‐Analysis of the Soy Effect Over Time

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Soy protein foods have attracted attention as useful plant protein foods with mild cholesterol‐lowering effects that are suitable for inclusion in therapeutic diets.
David J. A. Jenkins, Sonia Blanco Mejia, Laura Chiavaroli, Effie Viguiliouk, Siying S. Li, Cyril W. C. Kendall, Vladmir Vuksan, John L. Sievenpiper   +7 more
doaj   +1 more source

Evaluation of Amyloid β₄₂ Aggregation Inhibitory Activity of Commercial Dressings by A Microliter-Scale High-Throughput Screening System Using Quantum-Dot Nanoprobes

Foods, 2020
The aggregation and accumulation of amyloid β (Aβ) in the brain is a trigger of pathogenesis for Alzheimer’s disease. Previously, we developed a microliter-scale high-throughput screening (MSHTS) system for Aβ42 aggregation inhibitors using quantum-dot ...
Masahiro Kuragano, Wataru Yoshinari, Xuguang Lin, Keiya Shimamori, Koji Uwai, Kiyotaka Tokuraku   +5 more
doaj   +1 more source