Results 41 to 50 of about 135 (79)

The first characterized phage against a member of the ecologically important sphingomonads reveals high dissimilarity against all other known phages [PDF]

, 2017
This study describes the first molecular characterization of a bacteriophage infecting a member of the environmentally important Sphingomonadaceae family. Both bacteriophage Lacusarx and its host Sphingobium sp.
Kot, Witold, Tue Kjærgaard Nielsen, Witold Kot, Patrick Browne, Browne, Patrick, Neve, Horst, Lametsch, Rene, Nielsen, Tue Kjaergaard, René Lametsch, Lars Hestbjerg Hansen, Horst Neve, Carstens, Alexander Byth, Hansen, Lars Hestbjerg, Alexander Byth Carstens, Nielsen, Tue K., Hansen, Lars H., Carstens, Alexander B.   +16 more
core   +1 more source

Phage-Encoded Lysis Proteins (Holins and Spanins): Mechanisms and Emerging Applications

PHAGE: Therapy, Applications, and Research
Holins and spanins are bacteriophage-encoded enzymes that control the onset and efficiency of bacterial cell lysis in the late stage of the bacteriophage life cycle. Their ability to compromise bacterial membranes has attracted attention in various domains.
Nasiri Shoeibi, Zahra, Kianian, Farzaneh, Jahanbin, Behnaz, Abtahi, Hamidreza, Feizabadi, Mohammad Mehdi   +4 more
openaire   +3 more sources

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, Volume 13, Issue 29, 22 May 2026.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Investigation of Recombinantly Produced Endolysins Reveals a Modular Enzyme Shared by Several Enterobacteria Phages to Exhibit Broad‐Range Lytic Activity Against Different Orders of Gammaproteobacteria

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
The recombinant endolysin El1 derived from Enterobacteria bacteriophages showed potent bactericidal activity against Gram‐negative bacteria when applied exogenously, even in the absence of membrane‐permeabilizing agents, such as ethylenediaminetetraacetic acid (EDTA).
Tatjana Kazaka, Nikita Zrelovs, Inara Akopjana, Janis Bogans, Juris Jansons, Andris Dislers, Andris Kazaks   +6 more
wiley   +1 more source

The Final Step in Phage Lysis: The Role of the Rz-Rz1 Spanin Complex in the Disruption of the Outer Membrane [PDF]

, 2010
The purpose of the work described in this dissertation is to better understand the role of Rz and Rz1 function with respect to phage lysis. We determined using both a genetic and biochemical approach that the Rz protein is an inner membrane protein ...
Berry, Joel Dallas
core   +1 more source

Molecular Cloning and Functional Analysis of Holin and Endolysin From Escherichia Phage UE‐M6 as Potential Antibacterial Agents

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
We isolated phage UE‐M6 from wastewater and subsequently cloned, expressed, and purified its encoded endolysin (UE‐lysin) and holin (UE‐holin). Our results demonstrate that the combined application of UE‐lysin and UE‐holin exhibits significantly greater antibacterial activity than either protein alone, indicating a synergistic interaction between the ...
Hira Niaz, Mikael Skurnik, Fazal Adnan
wiley   +1 more source

Image_2_Characterization of Klebsiella pneumoniae bacteriophages, KP1 and KP12, with deep learning-based structure prediction.TIF

, 2023
Concerns over Klebsiella pneumoniae resistance to the last-line antibiotic treatment have prompted a reconsideration of bacteriophage therapy in public health.
Linh Khanh Nong (14098069), Youngju Kim (1503331), Jaehyung Kim (14494445), Donghyuk Kim (143424), Sang-Mok Lee (169322), Seung Bum Kim (6315908)   +5 more
core   +1 more source

Phage‐derived proteins: Advancing food safety through biocontrol and detection of foodborne pathogens

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 2, March 2025.
Abstract The emergence of antimicrobial‐resistant foodborne pathogens poses a continuous health risk and economic burden as they can easily spread through contaminated food. Therefore, the demand for new antimicrobial agents to address this problem is steadily increasing.
Dahee Choi, Sangryeol Ryu, Minsuk Kong
wiley   +1 more source

Klebsiella phages representing a novel clade of viruses with an unknown DNA modification and biotechnologically interesting enzymes [PDF]

, 2016
Lytic bacteriophages and phage-encoded endolysins (peptidoglycan hydrolases) provide a source for the development of novel antimicrobial strategies.
Yves Briers, Drulis-Kawa, Zuzanna, Maciejewska, B, Kęsik-Szeloch, Agata, Grazyna Majkowska-Skrobek, Kropinski, Andrew M., Cava, Felipe,, Majkowska-Skrobek, Grazyna, Bartosz Roszniowski, Briers, Yves, Briers, Y, Kęsik-Szeloch, A, Rob Lavigne, Drulis-Kawa, Z, Akbar Espaillat, Agata Kęsik-Szeloch, Zuzanna Drulis-Kawa, Kropinski, Andrew M, Espaillat, Akbar,, Barbara Maciejewska, Majkowska-Skrobek, G, Roszniowski, Bartosz, Felipe Cava, Maciejewska, Barbara, Cava, Felipe, Espaillat, Akbar, Lavigne, Rob, Andrew M. Kropinski, Roszniowski, B, Lavigne, R, Kropinski, AM   +30 more
core   +2 more sources

Limitation of the Lytic Effect of Bacteriophages on Salmonella and Other Enteric Bacterial Pathogens and Approaches to Overcome

International Journal of Microbiology, Volume 2025, Issue 1, 2025.
Bacteriophages (phages) have emerged as promising agents for combating bacterial pathogens, including nontyphoidal Salmonella enterica (S. enterica), the most common foodborne pathogen worldwide. The emergence of antimicrobial‐resistant (AMR) S. enterica poses a severe healthcare issue.
Chuan-Wei Tung, Dita Julianingsih, Anna Phan, Christa Canagarajah, Zabdiel Alvarado-Martínez, Debabrata Biswas, Bassem Refaat   +6 more
wiley   +1 more source