Results 21 to 30 of about 135 (79)

Diversity, evolution and life strategies of CbK‐like phages

Environmental Microbiology, Volume 25, Issue 7, Page 1250-1264, July 2023., 2023
Abstract Caulobacter phage CbK has been extensively studied as a model system in virology and bacteriology. Lysogeny‐related genes have been found in each CbK‐like isolate, suggesting a life strategy of both lytic and lysogenic cycles. However, whether CbK‐related phages can enter lysogeny is still undetermined.
Ruijie Ma, Xiaowei Chen, Yingying Li, Nianzhi Jiao, Rui Zhang   +4 more
wiley   +1 more source

Increased sensitivity of Aggregatibacter actinomycetemcomitans to human serum is mediated by induction of a bacteriophage

Molecular Oral Microbiology, Volume 38, Issue 1, Page 58-70, February 2023., 2023
Abstract Aggregatibacter actinomycetemcomitans, a Gram‐negative oral pathobiont causing aggressive periodontitis and systemic infections, demonstrates serum resistance. We have identified a dsDNA‐tailed bacteriophage, S1249, which was found to convert from this microorganism inducible by human serum into a lytic state to kill the bacterium.
Gaoyan G. Tang‐Siegel, Casey Chen, Keith P. Mintz   +2 more
wiley   +1 more source

Isolation and characterization of a novel Lambda‐like phage infecting the bloom‐forming cyanobacteria Cylindrospermopsis raciborskii

Environmental Microbiology, Volume 24, Issue 5, Page 2435-2448, May 2022., 2022
Summary Cylindrospermopsis raciborskii is a central bloom‐forming cyanobacteria. However, despite its ecological significance, little is known of its interactions with the phages that infect it. Currently, only a single sequenced genome of a Cylindrospermopsis‐infecting phage is publicly available. Here we describe the isolation and characterization of
Emmanuelle Laloum, Esther Cattan‐Tsaushu, Daniel A. Schwartz, Hanaa Shaalan, Hagay Enav, Dikla Kolan, Sarit Avrani   +6 more
wiley   +1 more source

Monomodular Pseudomonas aeruginosa phage JG004 lysozyme (Pae87) contains a bacterial surface‐active antimicrobial peptide‐like region and a possible substrate‐binding subdomain

Acta Crystallographica Section D, Volume 78, Issue 4, Page 435-454, April 2022., 2022
The structure of the monomodular Pseudomonas aeruginosa bacteriophage JG004 lysin Pae87 is presented and investigated in relation to repurposing its function as an antimicrobial agent. The structure with its peptidoglycan ligand revealed a possible cell‐wall‐binding region.
Roberto Vázquez, Mateo Seoane-Blanco, Virginia Rivero-Buceta, Susana Ruiz, Mark J. van Raaij, Pedro García   +5 more
wiley   +1 more source

Phage-Encoded Cationic Antimicrobial Peptide Required for Lysis [PDF]

, 2022
Most phages of Gram-negative bacteria hosts encode spanins for disruption of the outer membrane, which is the last step in host lysis. However, bioinformatic analysis indicates that ∼15% of these phages lack a spanin gene, suggesting they have an ...
Ramsey, Jolene, Moreland, Russell, III, Holt, Ashley, Sule, Preeti, Young, Ry, O’Leary, Chandler, Galbadage, Thushara, Cirillo, Jeffrey D., Cahill, Jesse, Maddox, Lori T., Martin, Cody, Sharan, Riti, Moreland, Russell, Lori T. Maddox, Chandler O’Leary, Jolene Ramsey, Russell Moreland, Ashley Holt, Ry Young, Jesse Cahill, Jeffrey D. Cirillo, Riti Sharan, Preeti Sule, Cody Martin, Thushara Galbadage   +24 more
core   +1 more source

A holin/peptidoglycan hydrolase‐dependent protein secretion system

Molecular Microbiology, Volume 115, Issue 3, Page 345-355, March 2021., 2021
We describe a protein secretion system in Gram‐negative bacteria that uses a holin membrane protein in tandem with a cell wall editing enzyme. The pairing of holins from different families with various types of peptidoglycan hydrolases suggests that this secretion pathway evolved multiple times.
Tracy Palmer, Alexander J. Finney, Chayan Kumar Saha, Gemma C. Atkinson, Frank Sargent   +4 more
wiley   +1 more source

The Analysis of OmpA and Rz/Rz1 of Lytic Bacteriophage from Surabaya, Indonesia

Scientifica, Volume 2021, Issue 1, 2021., 2021
A good strategy to conquer the Escherichia coli‐cause food‐borne disease could be bacteriophages. Porins are a type of β‐barrel proteins with diffuse channels and OmpA, which has a role in hydrophilic transport, is the most frequent porin in E. coli; it was also chosen as the potential receptor of the phage. And the Rz/Rz1 was engaged in the breakup of
Tessa Sjahriani, Eddy Bagus Wasito, Wiwiek Tyasningsih, Fernando Rosado Spilki   +3 more
wiley   +1 more source

Using custom Galaxy workflows to reproducibly search for bacteriophage spanin proteins reveals distinct population distributions

, 2021
Bacteriophage (phage), bacterial viruses, are currently under investigation for use as therapeutics against antibiotic-resistant bacteria. Careful phage genome annotation is essential in that effort. Galaxy workflows coupled with Apollo allow that needed high-quality annotation.
Snowden, Jason, Ross, Curtis, Ramsey, Jolene, Ry Young   +3 more
openaire   +1 more source

The Role of Spanins in Phage Lysis [PDF]

, 2020
The work described in this dissertation addresses how spanins function during phage lysis, focusing on the 2CS system of phage lambda, in which Rz and Rz1 are the prototype i-spanin (inner membrane subunit) and o-spanin (OM lipoprotein subunits) of the ...
Rajaure, Manoj
core   +1 more source

The αvβ6 integrin in cancer cell‐derived small extracellular vesicles enhances angiogenesis

Journal of Extracellular Vesicles, Volume 9, Issue 1, September 2020., 2020
ABSTRACT Prostate cancer (PrCa) cells crosstalk with the tumour microenvironment by releasing small extracellular vesicles (sEVs). sEVs, as well as large extracellular vesicles (LEVs), isolated via iodixanol density gradients from PrCa cell culture media, express the epithelial‐specific αvβ6 integrin, which is known to be induced in cancer.
Shiv Ram Krishn, Israa Salem, Fabio Quaglia, Nicole M. Naranjo, Ekta Agarwal, Qin Liu, Srawasti Sarker, Jessica Kopenhaver, Peter A. McCue, Paul H. Weinreb, Shelia M. Violette, Dario C. Altieri, Lucia R. Languino   +12 more
wiley   +1 more source