Results 11 to 20 of about 135 (79)

Suppressor Analysis of the Fusogenic Lambda Spanins [PDF]

Journal of Virology, 2017
ABSTRACT The final step of lysis in phage λ infections of Escherichia coli is mediated by the spanins Rz and Rz1. These proteins form a complex that bridges the cell envelope and that has been proposed to cause fusion of the inner and outer membranes.
Jesse, Cahill, Manoj, Rajaure, Ashley, Holt, Russell, Moreland, Chandler, O'Leary, Aneesha, Kulkarni, Jordan, Sloan, Ry, Young   +7 more
openaire   +3 more sources

Bacteriophage-encoded lethal membrane disruptors: Advances in understanding and potential applications

Frontiers in Microbiology, 2022
Holins and spanins are bacteriophage-encoded membrane proteins that control bacterial cell lysis in the final stage of the bacteriophage reproductive cycle.
Gayan S. Abeysekera, Michael J. Love, Michael J. Love, Sarah H. Manners, Craig Billington, Renwick C. J. Dobson, Renwick C. J. Dobson   +6 more
doaj   +2 more sources

Characterization of Klebsiella pneumoniae bacteriophages, KP1 and KP12, with deep learning-based structure prediction

Frontiers in Microbiology, 2023
Concerns over Klebsiella pneumoniae resistance to the last-line antibiotic treatment have prompted a reconsideration of bacteriophage therapy in public health.
Youngju Kim, Youngju Kim, Sang-Mok Lee, Linh Khanh Nong, Jaehyung Kim, Seung Bum Kim, Donghyuk Kim   +6 more
doaj   +2 more sources

Additional file 1: of Phage spanins: diversity, topological dynamics and gene convergence

, 2018
Figure S1. Flowchart showing the manual search protocol to identify potential spanin candidates from genomes of phages infecting Gram-negative hosts. All the corrected CDS collected from the phage genome were run through TMHMM 2.0 and LipoP 1.0 with default parameters.
Kongari, Rohit, Rajaure, Manoj, Cahill, Jesse, Rasche, Eric, Mijalis, Eleni, Berry, Joel, Young, Ry   +6 more
openaire   +2 more sources

Pectobacterium atrosepticum Phage vB_PatP_CB5: A Member of the Proposed Genus ‘Phimunavirus’ [PDF]

Viruses, 2018
Pectobacterium atrosepticum is a phytopathogen of economic importance as it is the causative agent of potato blackleg and soft rot. Here we describe the Pectobacterium phage vB_PatP_CB5 (abbreviated as CB5), which specifically infects the bacterium.
Colin Buttimer, Alan Lucid, Horst Neve, Charles M. A. P. Franz, Jim O’Mahony, Dann Turner, Rob Lavigne, Aidan Coffey   +7 more
doaj   +2 more sources

Assessment of the phi6 Lysis System Using Genetic Complementation and Heterologous Expression in Escherichia coli and Pseudomonas syringae

Frontiers in Microbiology
The RNA cystovirus phi6 represents a unique evolutionary outlier, encoding a holin and endolysin similar to tailed phages, yet lacking an identified gene for outer membrane disruption.
Jesse L Cahill, Rabia Sannam Khan, Greyson Lasley   +2 more
exaly   +3 more sources

Isolation and preliminary characterization of a novel bacteriophage vB_KquU_φKuK6 that infects the multidrug-resistant pathogen Klebsiella quasipneumoniae [PDF]

Frontiers in Microbiology
BackgroundKlebsiella quasipneumoniae (previously known as K. pneumoniae K6) strains are among the multidrug-resistant hypervirulent bacterial pathogens. Phage therapy can help treat infections caused by such pathogens.
Isaac P. Miller, Alma G. Laney, Geoffrey Zahn, Brock J. Sheehan, Kiara V. Whitley, Ruhul H. Kuddus   +5 more
doaj   +2 more sources

Spatial and temporal control of lysis by the lambda holin

mBio
The infection cycle of phage λ terminates in lysis mediated by three types of lysis proteins, each disrupting a layer in the bacterial envelope: the S105 holin, the R endolysin, and the Rz/Rz1 spanin complex targeting the inner membrane, cell wall or ...
Jesse Cahill, Ashley Holt, Matthew Theodore, Russell Moreland, Chandler O'Leary, Cody Martin, Kelsey Bettridge, Jie Xiao, Ry Young   +8 more
doaj   +2 more sources

A Novel Lytic Salmonella Phage Harboring an Unprecedented Tail-Protein Domain Combination Capable of Lysing Cross-Host-Transmitted Salmonella Strains

Foods
The emergence of multidrug-resistant Salmonella poses a significant threat to global public health and food safety, necessitating the urgent search for new strategies to replace conventional antibiotics.
Ling Zhang, Mingqiang Guo, Xiaoyu Ma, Wei Wang, Wanpeng Ma, Yifan Liu, Junxiang Wei, Zhanqiang Su   +7 more
doaj   +2 more sources

Endolysin Regulation in Phage Mu Lysis

mBio, 2022
Bacteriophage Mu is a paradigm coliphage studied mainly because of its use of transposition for genome replication. However, in extensive nonsense mutant screens, only one lysis gene has been identified, the endolysin gp22.
Jake S. Chamblee, Jolene Ramsey, Yi Chen, Lori T. Maddox, Curtis Ross, Kam H. To, Jesse L. Cahill, Ry Young   +7 more
doaj   +1 more source